Molecular signature of recent thymic selection events on effector and regulatory CD4 T lymphocytes. (Q36593490)

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8 January 2020

title

Molecular signature of recent thymic selection events on effector and regulatory CD4 T lymphocytes (English)

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2

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author name string

Paola Romagnoli

series ordinal

1

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8 January 2020

Joost P M van Meerwijk

series ordinal

3

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language of work or name

English

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publication date

1 November 2005

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8 January 2020

published in

Journal of Immunology

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8 January 2020

volume

175

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issue

9

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8 January 2020

page(s)

5751-5758

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Regulatory T cell lineage specification by the forkhead transcription factor foxp3

8 January 2020

cites work

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Homeostatic maintenance of natural Foxp3( ) CD25( ) CD4( ) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

9 September 2017

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Conversion of CD4 CD25- cells into CD4 CD25 regulatory T cells in vivo requires B7 costimulation, but not the thymus

9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells

9 September 2017

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CD4 CD25 T cells regulate virus-specific primary and memory CD8 T cell responses

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9 September 2017

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9 September 2017

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CD4 CD25 regulatory T cells control Leishmania major persistence and immunity

9 September 2017

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9 September 2017

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Donor-type CD4( )CD25( ) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation

9 September 2017

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Intercellular transfer of antigen-presenting cell determinants onto T cells: molecular mechanisms and biological significance.

9 September 2017

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Regulatory T cells in the control of immune pathology.

9 September 2017

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Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4( )25( ) immunoregulatory T cells

9 September 2017

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Regulatory T cells: key controllers of immunologic self-tolerance

9 September 2017

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Regulatory T cells in autoimmmunity*.

9 September 2017

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Peripheral T cell survival

9 September 2017

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Thymus and autoimmunity: production of CD25 CD4 naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance

9 September 2017

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Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells

9 September 2017

1 reference

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Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

9 September 2017

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Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor.

9 September 2017

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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

9 September 2017

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CIITA activates the expression of MHC class II genes in mouse T cells

9 September 2017

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Regulation of major histocompatibility complex class-II genes: X, Y and other letters of the alphabet

9 September 2017

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Mice lacking MHC class II molecules

9 September 2017

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Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors

9 September 2017

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Induction of antigen-specific tolerance to bone marrow allografts with CD4 CD25 T lymphocytes

9 September 2017

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Generation of anergic and potentially immunoregulatory CD25 CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen

30 September 2017

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T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells

30 September 2017

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TCR-Mediated internalization of peptide-MHC complexes acquired by T cells

30 September 2017

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Cloned T Lymphocytes and Monoclonal Antibodies as Probes for Cell Surface Molecules Active in T Cell-Mediated Cytolysis

30 September 2017

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Evidence for a thymus-dependent form of tolerance that is not based on elimination or anergy of reactive T cells

30 September 2017

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Cutting edge: CTLs rapidly capture membrane fragments from target cells in a TCR signaling-dependent manner

30 September 2017

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Homeostasis limits the development of mature CD8 but not CD4 thymocytes

28 June 2018

1 reference

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Mouse mammary tumor virus: immunological interplays between virus and host

28 June 2018

1 reference

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Negative selection in the thymus includes semimature T cells

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346488

Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346488

Induction by antigen of intrathymic apoptosis of CD4 CD8 TCRlo thymocytes in vivo

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346488

Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8 T cells.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346488

The majority of CD4 8- thymocytes are functionally immature

28 June 2018

1 reference

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Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells

28 June 2018

1 reference

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Antigen presentation by mouse CD4 T cells involving acquired MHC class II:peptide complexes: another mechanism to limit clonal expansion?

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346488

Peptide specificity of thymic selection of CD4 CD25 T cells

20 September 2018

1 reference

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T cells down-modulate peptide-MHC complexes on APCs in vivo

20 September 2018

1 reference

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Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

20 September 2018

1 reference

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Anergy and suppression regulate CD4( ) T cell responses to a self peptide.

20 September 2018

1 reference

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MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent

20 September 2018

1 reference

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Another view of the selective model of thymocyte selection

20 September 2018

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Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes.

20 September 2018

1 reference

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Tracing interactions of thymocytes with individual stromal cell partners

20 September 2018

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12 December 2020

CD4 T cell tolerance to nuclear proteins induced by medullary thymic epithelium

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12 December 2020

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1 reference

12 December 2020

Identification of a naturally occurring ligand for thymic positive selection

1 reference

12 December 2020

Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire

1 reference

12 December 2020

CD25- T cells generate CD25 Foxp3 regulatory T cells by peripheral expansion

1 reference

12 December 2020

Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression

1 reference

12 December 2020

Dissociation of thymic positive and negative selection in transgenic mice expressing major histocompatibility complex class I molecules exclusively on thymic cortical epithelial cells

1 reference

12 December 2020

Preferential recognition of self antigens despite normal thymic deletion of CD4( )CD25( ) regulatory T cells

1 reference

12 December 2020

Generation of CD4( )CD25( ) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression

1 reference

12 December 2020

The infusion of ex vivo activated and expanded CD4( )CD25( ) immune regulatory cells inhibits graft-versus-host disease lethality

1 reference

12 December 2020

Origin of regulatory T cells with known specificity for antigen

1 reference

12 December 2020

What is trogocytosis and what is its purpose?

1 reference

12 December 2020

Regulatory T cells mediate maternal tolerance to the fetus

1 reference

12 December 2020

Recognition of the peripheral self by naturally arising CD25 CD4 T cell receptors

1 reference

12 December 2020

Cell surface appearance of unexpected host MHC determinants on thymocytes from radiation bone marrow chimeras

1 reference

12 December 2020

A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication

1 reference

12 December 2020

Structural Differences in Cell Surface T25 Polypeptides from Thymocytes and Cloned T Cells

1 reference

12 December 2020

Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation

1 reference

12 December 2020

A nondeletional mechanism of thymic self tolerance

1 reference

12 December 2020

Thymic selection of CD4 CD25 regulatory T cells induced by an agonist self-peptide

1 reference

12 December 2020

Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance

1 reference

12 December 2020

10.4049/JIMMUNOL.175.9.5751

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16237066 AND SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16237066 AND SRC:MED&resulttype=core&format=json

8 January 2020

PubMed publication ID

16237066

1 reference