High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control (Q36584830)

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scientific article published on 11 December 2012

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English	High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control	scientific article published on 11 December 2012

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scholarly article

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Europe PubMed Central

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15 August 2017

High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control (English)

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15 August 2017

Bruce D. Walker

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Bruce D Walker

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Florencia Pereyra

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Florencia Pereyra

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David Heckerman

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David Heckerman

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Alicja Piechocka-Trocha

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Alicja Piechocka-Trocha

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Philip L. De Jager

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Philip L De Jager

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Jacqueline Proudfoot

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Jacqueline Proudfoot

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Donna Marie L Alvino

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Donna Marie Alvino

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Seanna Vine

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Filippos Porichis

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Filippos Porichis

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Zaza M Ndhlovu

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Kevin Cesa

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Ashley McMullen

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Ashley McMullen

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Eleni Stampouloglou

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Eleni Stampouloglou

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Lori B Chibnik

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15 August 2017

author name string

R Brad Jones

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Meghan G Hart

10

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Carl Kadie

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Daniel E Kaufmann

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publication date

11 December 2012

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15 August 2017

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121

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5

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801-811

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15 August 2017

Elite controllers with low to absent effector CD8 T cell responses maintain highly functional, broadly directed central memory responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Protective HIV-specific CD8 T cells evade Treg cell suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Increased HIV-specific CD8 T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Next-generation sequencing for HLA typing of class I loci

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Immunodominant HIV-Specific CD8 T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Phenotypic and functional profile of HIV-inhibitory CD8 T cells elicited by natural infection and heterologous prime/boost vaccination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Human leukocyte antigen class I supertypes and HIV-1 control in African Americans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Defective human immunodeficiency virus-specific CD8 T-cell polyfunctionality, proliferation, and cytotoxicity are not restored by antiretroviral therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLA-B*2705, bind peptides with sequence similarity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Human immunodeficiency virus type 1-specific CD8 T-cell responses during primary infection are major determinants of the viral set point and loss of CD4 T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Treatment interruption to boost specific HIV immunity in acute infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Lytic granule loading of CD8 T cells is required for HIV-infected cell elimination associated with immune control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Skewed association of polyfunctional antigen-specific CD8 T cell populations with HLA-B genotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8( ) T Cell Response against HIV-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Human leukocyte antigen B58 supertype and human immunodeficiency virus type 1 infection in native Africans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Maintenance of viral suppression in HIV-1-infected HLA-B*57 elite suppressors despite CTL escape mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8 T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

HIV controllers: a homogeneous group of HIV-1-infected patients with spontaneous control of viral replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Limited durability of viral control following treated acute HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

The differential ability of HLA B*5701 long-term nonprogressors and progressors to restrict human immunodeficiency virus replication is not caused by loss of recognition of autologous viral gag sequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Lineage relationship and protective immunity of memory CD8 T cell subsets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Analysis of total human immunodeficiency virus (HIV)-specific CD4( ) and CD8( ) T-cell responses: relationship to viral load in untreated HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Memory CD8 T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Suppression of HIV replication in the resting CD4 T cell reservoir by autologous CD8 T cells: implications for the development of therapeutic strategies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Dramatic rise in plasma viremia after CD8( ) T cell depletion in simian immunodeficiency virus-infected macaques.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

Control of viremia in simian immunodeficiency virus infection by CD8 lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

9 September 2017

IL-21R on T cells is critical for sustained functionality and control of chronic viral infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

20 September 2018

Substantial intrapatient differences in the breadth and specificity of HIV-specific CD8 T-cell interferon-gamma and proliferation responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

20 September 2018

Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

20 September 2018

Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

20 September 2018

Maintenance of large numbers of virus-specific CD8 T cells in HIV-infected progressors and long-term nonprogressors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

20 September 2018

CD8 T-cell responses to different HIV proteins have discordant associations with viral load

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563365

4 December 2018

Vaccination in humans generates broad T cell cytokine responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23233659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-specific CD8 T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23233659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/23233659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

1 reference

https://pubmed.ncbi.nlm.nih.gov/23233659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2012-06-436295

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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