An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva (Q36566730)

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29 January 2020

title

An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva (English)

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fibrodysplasia ossificans progressiva

29 January 2020

main subject

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author

Andrew Maidment

7

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29 January 2020

author name string

Salin A Chakkalakal

1

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29 January 2020

Deyu Zhang

2

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29 January 2020

Andria L Culbert

3

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29 January 2020

Michael R Convente

4

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29 January 2020

Robert J Caron

5

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29 January 2020

Alexander C Wright

6

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29 January 2020

Frederick S Kaplan

8

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29 January 2020

Eileen M Shore

9

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29 January 2020

publication date

1 August 2012

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Journal of Bone and Mineral Research

29 January 2020

published in

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volume

27

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issue

8

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29 January 2020

page(s)

1746-1756

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describes a project that uses

29 January 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

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Molecular consequences of the ACVR1(R206H) mutation of fibrodysplasia ossificans progressiva.

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ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation

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The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization

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Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1

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Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva.

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Identifiers

DOI

10.1002/JBMR.1637

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22508565 AND SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22508565 AND SRC:MED&resulttype=core&format=json

29 January 2020

PubMed publication ID

22508565

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22508565 AND SRC:MED&resulttype=core&format=json