Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. (Q36558058)

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5 January 2020

title

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain (English)

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Malene Ringkjøbing Jensen

5 January 2020

author

5

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Efstratios Mylonas

6

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8

Martin Blackledge

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5 January 2020

author name string

Mark Wells

1

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5 January 2020

Henning Tidow

2

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5 January 2020

Trevor J Rutherford

3

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5 January 2020

Phineus Markwick

4

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5 January 2020

Dmitri I Svergun

7

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Alan R Fersht

9

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language of work or name

English

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publication date

7 April 2008

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Proceedings of the National Academy of Sciences of the United States of America

5 January 2020

published in

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volume

105

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issue

15

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page(s)

5762-5767

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Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex

5 January 2020

cites work

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Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53

30 September 2017

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Structure-function-rescue: the diverse nature of common p53 cancer mutants

30 September 2017

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Identifying long-range structure in the intrinsically unstructured transactivation domain of p53.

30 September 2017

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Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression

30 September 2017

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The central region of HDM2 provides a second binding site for p53.

30 September 2017

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30 September 2017

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Natively unfolded proteins

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Foldon, the natural trimerization domain of T4 fibritin, dissociates into a monomeric A-state form containing a stable beta-hairpin: atomic details of trimer dissociation and local beta-hairpin stability from residual dipolar couplings

30 September 2017

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Importance of solvent accessibility and contact surfaces in modeling side-chain conformations in proteins.

30 September 2017

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Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

30 September 2017

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Intrinsic disorder in cell-signaling and cancer-associated proteins

30 September 2017

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Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP

30 September 2017

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Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

30 September 2017

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30 September 2017

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

30 September 2017

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

30 September 2017

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Refined solution structure of the oligomerization domain of the tumour suppressor p53

30 September 2017

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30 September 2017

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An HNCO-based Pulse Scheme for the Measurement of 13Cα-1Hα One-bond Dipolar couplings in 15N, 13C Labeled Proteins

30 September 2017

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21 September 2018

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21 September 2018

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21 September 2018

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21 September 2018

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21 September 2018

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21 September 2018

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21 September 2018

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21 September 2018

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Mapping the Conformational Landscape of Urea-Denatured Ubiquitin Using Residual Dipolar Couplings

21 September 2018

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21 January 2018

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21 January 2018

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Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53

21 January 2018

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Defining Long-Range Order and Local Disorder in Native α-Synuclein Using Residual Dipolar Couplings

21 January 2018

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A simple apparatus for generating stretched polyacrylamide gels, yielding uniform alignment of proteins and detergent micelles

21 January 2018

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12 December 2020

Exploring multiple timescale motions in protein GB3 using accelerated molecular dynamics and NMR spectroscopy

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12 December 2020

A set of HNCO-based experiments for measurement of residual dipolar couplings in 15N, 13C, (2H)-labeled proteins

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12 December 2020

Measurement of (1)J(NC') and (2)J(H(N))(C') couplings from spin-state-selective two-dimensional correlation spectrum

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Identifiers

DOI

10.1073/PNAS.0801353105

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18391200 AND SRC:MED&resulttype=core&format=json

5 January 2020

0 references

1 reference

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5 January 2020

PubMed publication ID

18391200

1 reference