CYP4B1: an enigmatic P450 at the interface between xenobiotic and endobiotic metabolism (Q36551130)

14 August 2017

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title

CYP4B1: an enigmatic P450 at the interface between xenobiotic and endobiotic metabolism (English)

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14 August 2017

Brian R Baer

1

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14 August 2017

Allan E Rettie

series ordinal

2

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14 August 2017

language of work or name

English

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publication date

1 January 2006

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14 August 2017

published in

Drug Metabolism Reviews

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14 August 2017

volume

38

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14 August 2017

issue

3

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14 August 2017

page(s)

451-476

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Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test

14 August 2017

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Retinoic acid induces corneal epithelial CYP4B1 gene expression and stimulates the synthesis of inflammatory 12-hydroxyeicosanoids

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Bioactivation of 4-ipomeanol by CYP4B1: adduct characterization and evidence for an enedial intermediate

21 January 2018

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Autoradiographic evidence of 3-methylindole covalent binding to pulmonary epithelial cells in the goat

21 January 2018

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Cytochrome P450 hydroxylation of carbon atoms of the alkyl chain of symmetrical N-nitrosodialkylamines by human liver microsomes

21 January 2018

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Regulation of cyclooxygenase-2 by hypoxia and peroxisome proliferators in the corneal epithelium

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Biochemical mechanisms in chemical-induced lung injury: roles of metabolic activation

21 January 2018

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Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles

21 January 2018

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Characterization of Pulmonary CYP4B2, Specific Catalyst of Methyl Oxidation of 3-Methylindole

21 January 2018

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Autocatalytic processing of heme by lactoperoxidase produces the native protein-bound prosthetic group.

21 January 2018

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Species and strain differences in target organ alkylation and toxicity by 4-ipomeanol. Predictive value of covalent binding in studies of target organ toxicities by reactive metabolites

21 January 2018

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Structure of the green heme in myeloperoxidase

21 January 2018

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Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR

21 January 2018

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Positional specificity of rabbit CYP4B1 for omega-hydroxylation1 of short-medium chain fatty acids and hydrocarbons

21 January 2018

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Cytochrome p450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver.

21 January 2018

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cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine

21 January 2018

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Active site characteristics of CYP4B1 probed with aromatic ligands

21 January 2018

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Covalent linkage of prosthetic heme to CYP4 family P450 enzymes

21 January 2018

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Human CYP4B1 gene in the japanese population analyzed by denaturing HPLC.

21 January 2018

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Covalently linked heme in cytochrome p4504a fatty acid hydroxylases

21 January 2018

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Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases

21 January 2018

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A transgenic mouse expressing human CYP4B1 in the liver

21 January 2018

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Mutagenic Activation of 3-Methoxy-4-aminoazobenzene by Mouse Renal Cytochrome-P450 CYP4B1: Cloning and Characterization of Mouse CYP4B1

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Mutagenic activation of urinary bladder carcinogens by CYP4B1 and the presence of CYP4B1 in bladder mucosa

21 January 2018

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CYP4B1 is a possible risk factor for bladder cancer in humans

21 January 2018

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Androgen regulation of CYP4B1 responsible for mutagenic activation of bladder carcinogens in the rat bladder: detection of CYP4B1 mRNA by competitive reverse transcription-polymerase chain reaction

21 January 2018

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The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue

21 January 2018

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Hormonal regulation and characterisation of the mouse Cyp4b1 gene 5'-flanking region.

21 January 2018

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Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11

21 January 2018

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Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant

21 January 2018

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Promoter activity and regulation of the corneal CYP4B1 gene by hypoxia

21 January 2018

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Corneal epithelial VEGF and cytochrome P450 4B1 expression in a rabbit model of closed eye contact lens wear

21 January 2018

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Species-specific expression of CYP4B1 in rabbit and human gastrointestinal tissues

21 January 2018

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Localization of cytochromes P450 in human tissues: implications for chemical toxicity

21 January 2018

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Transfection of cytochrome P4504B1 into the cornea increases angiogenic activity of the limbal vessels

21 January 2018

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Rabbit cytochrome P450 4B1: A novel prodrug activating gene for pharmacogene therapy of hepatocellular carcinoma.

21 January 2018

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Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

21 January 2018

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Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping

21 January 2018

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Molecular mechanisms regulating human CYP4B1 lung-selective expression

21 January 2018

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The heme prosthetic group of lactoperoxidase. Structural characteristics of heme l and heme l-peptides

21 January 2018

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New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol

21 January 2018

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Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding

21 January 2018

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The cytochrome P450 4 (CYP4) family

21 January 2018

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Mechanistic studies on the cytochrome P450-catalyzed dehydrogenation of 3-methylindole

21 January 2018

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4-Ipomeanol and 2-aminoanthracene cytotoxicity in C3H/10T1/2 cells expressing rabbit cytochrome P450 4B1.

21 January 2018

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Enhanced green fluorescent protein fusion proteins of herpes simplex virus type 1 thymidine kinase and cytochrome P450 4B1: applications for prodrug-activating gene therapy

21 January 2018

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Bioactivation of a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, via glucuronidation. LC/MS/MS characterization of the GSH-glucuronide diconjugates

21 January 2018

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CYP4B1 activates 4-ipomeanol in rat lung

21 January 2018

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Cloning, sequencing, and cDNA-directed expression of the rat renal CYP4A2: arachidonic acid omega-hydroxylation and 11,12-epoxidation by CYP4A2 protein

21 January 2018

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P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

21 January 2018

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The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution

21 January 2018

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Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

21 January 2018

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Crystal structure of human cytochrome P450 2C9 with bound warfarin

21 January 2018

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The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies

21 January 2018

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The rabbit pulmonary monooxygenase system: Characteristics and activities of two forms of pulmonary cytochrome P-450

21 January 2018

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Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes

21 January 2018

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Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen

21 January 2018

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https://api.crossref.org/works/10.1080/03602530600688503

The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution

21 January 2018

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https://api.crossref.org/works/10.1080/03602530600688503

cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA library of human placenta. Gene structure and expression

21 January 2018

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https://api.crossref.org/works/10.1080/03602530600688503

Mechanisms of 3-methylindole pneumotoxicity

21 January 2018

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https://api.crossref.org/works/10.1080/03602530600688503

The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance.

21 January 2018

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Identification of a meander region proline residue critical for heme binding to cytochrome P450: implications for the catalytic function of human CYP4B1.

21 January 2018

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Covalent Heme Binding to CYP4B1 via Glu310 and a Carbocation Porphyrin Intermediate

21 January 2018

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https://api.crossref.org/works/10.1080/03602530600688503

Genotyping and site-directed mutagenesis of a cytochrome P450 meander Pro-X-Arg motif critical to CYP4B1 catalysis

21 January 2018

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https://api.crossref.org/works/10.1080/03602530600688503

Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s

21 January 2018

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https://api.crossref.org/works/10.1080/03602530600688503

Evidence for the Clara cell as a site of cytochrome P450-dependent mixed-function oxidase activity in lung

21 January 2018

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Characterization of Amino Acid and Glutathione Adducts ofcis-2-Butene-1,4-dial, a Reactive Metabolite of Furan

21 January 2018

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10.1080/03602530600688503

21 January 2018

Identifiers

DOI

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14 August 2017

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