Inhibitors of the HSP90 molecular chaperone: current status (Q36543819)

14 August 2017

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title

Inhibitors of the HSP90 molecular chaperone: current status (English)

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14 August 2017

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2

Paul Workman

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14 August 2017

Swee Sharp

1

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14 August 2017

publication date

1 January 2006

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Advances in Cancer Research

14 August 2017

published in

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14 August 2017

volume

95

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14 August 2017

page(s)

323-348

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Halohydrin and oxime derivatives of radicicol: synthesis and antitumor activities

14 August 2017

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7 January 2021

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Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies

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Increase of P-glycoprotein-mediated drug resistance by hsp 90 beta.

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7 January 2021

Orally active purine-based inhibitors of the heat shock protein 90.

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7 January 2021

17-(Allylamino)-17-demethoxygeldanamycin activity in human melanoma models

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7 January 2021

Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide

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7 January 2021

The HSP90 family of genes in the human genome: insights into their divergence and evolution

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7 January 2021

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

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7 January 2021

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

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7 January 2021

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

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7 January 2021

Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin

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7 January 2021

Geldanamycin, a new antibiotic

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7 January 2021

Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design

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7 January 2021

Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1.

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7 January 2021

Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats

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7 January 2021

Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts

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7 January 2021

Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness

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7 January 2021

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7 January 2021

Labeling of v-Src and BCR-ABL tyrosine kinases with [14C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism

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7 January 2021

Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.

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7 January 2021

Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer

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7 January 2021

Is cisplatin-induced cell death always produced by apoptosis?

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https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

The role of Hsp90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation

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7 January 2021

V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors

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7 January 2021

Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition

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7 January 2021

The Hallmarks of Cancer

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7 January 2021

Design of quinolinedione-based geldanamycin analogues

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7 January 2021

Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.

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https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

The assembly and intermolecular properties of the hsp70-Hop-hsp90 molecular chaperone complex

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https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein

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7 January 2021

Heat shock protein 90 as a molecular target for cancer therapeutics

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https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone HSP90.

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7 January 2021

Clinical and biological significance of HSP89 alpha in human breast cancer

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7 January 2021

Heat shock protein 90 inhibitors. A text book example of medicinal chemistry?

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7 January 2021

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

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https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Mechanisms of resistance to cisplatin

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https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Recognition of cisplatin adducts by cellular proteins

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator

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7 January 2021

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

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7 January 2021

A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts

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7 January 2021

Evidence that the novobiocin-sensitive ATP-binding site of the heat shock protein 90 (hsp90) is necessary for its autophosphorylation

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90.

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7 January 2021

Drugs five years later. Cisplatin

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7 January 2021

HSP90 as a new therapeutic target for cancer therapy: the story unfolds

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7 January 2021

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

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7 January 2021

Recombinant antibodies: a natural partner in combinatorial antifungal therapy

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7 January 2021

Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90

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https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Design, synthesis, and biological evaluation of HSP90 inhibitors based on conformational analysis of radicicol and its analogues

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Structure, function, and mechanism of the Hsp90 molecular chaperone

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Rational design of shepherdin, a novel anticancer agent.

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Hsp90: chaperoning signal transduction

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated AKT.

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Taxol stabilizes microtubules in mouse fibroblast cells

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Radester, a novel inhibitor of the Hsp90 protein folding machinery

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Syntheses of photolabile novobiocin analogues

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Heat shock protein 90-antagonist destabilizes Bcr-Abl/HSP90 chaperone complex

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Stereospecific antitumor activity of radicicol oxime derivatives

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Development of Radicicol Analogues

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https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

A Nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Hsp90 isoforms: functions, expression and clinical importance

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

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https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Dissection of the contribution of individual domains to the ATPase mechanism of Hsp90.

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Current status of platinum-based antitumor drugs

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https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

A hydrophobic segment within the C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone

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https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Total Synthesis as a Resource in the Discovery of Potentially Valuable Antitumor Agents: Cycloproparadicicol

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https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Potent activity of a novel dimeric heat shock protein 90 inhibitor against head and neck squamous cell carcinoma in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Hsp90 inhibitors identified from a library of novobiocin analogues

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

High constitutive expression of heat shock protein 90α in human acute leukemia cells

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions

1 reference

https://api.crossref.org/works/10.1016/S0065-230X(06)95009-X

7 January 2021

10.1016/S0065-230X(06)95009-X

Identifiers

DOI

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14 August 2017

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