Recent developments in the molecular, biochemical and functional characterization of GPI8 and the GPI-anchoring mechanism [review]. (Q36511643)

14 August 2017

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title

Recent developments in the molecular, biochemical and functional characterization of GPI8 and the GPI-anchoring mechanism [review]. (English)

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14 August 2017

Michele A Zacks

1

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14 August 2017

Nisha Garg

series ordinal

2

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14 August 2017

publication date

1 May 2006

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Molecular Membrane Biology

14 August 2017

published in

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14 August 2017

volume

23

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14 August 2017

issue

3

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14 August 2017

page(s)

209-225

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14 August 2017

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Lipophosphoglycan expression and virulence in ricin-resistant variants of Leishmania major

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Lipophosphoglycan is not required for infection of macrophages or mice by Leishmania mexicana

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Phosphoglycan repeat-deficient Leishmania mexicana parasites remain infectious to macrophages and mice

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Persistence without pathology in phosphoglycan-deficient Leishmania major.

21 January 2018

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Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategies

21 January 2018

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Leishmania promastigotes require lipophosphoglycan to actively modulate the fusion properties of phagosomes at an early step of phagocytosis

21 January 2018

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Characterization of a Leishmania mexicana mutant defective in synthesis of free and protein-linked GPI glycolipids

21 January 2018

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The role of phosphomannose isomerase in Leishmania mexicana glycoconjugate synthesis and virulence

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Ether phospholipids and glycosylinositolphospholipids are not required for amastigote virulence or for inhibition of macrophage activation by Leishmania major.

21 January 2018

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Essential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8

21 January 2018

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A defect in glycosylphosphatidylinositol (GPI) transamidase activity in mutant K cells is responsible for their inability to display GPI surface proteins

21 January 2018

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The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase

21 January 2018

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No glycolipid anchors are added to Thy-1 glycoprotein in Thy-1-negative mutant thymoma cells of four different complementation classes

21 January 2018

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Molecular genetics of paroxysmal nocturnal hemoglobinuria

21 January 2018

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Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development.

21 January 2018

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Enhanced responses of glycosylphosphatidylinositol anchor-deficient T lymphocytes

21 January 2018

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GPI-anchor deficiency in myeloid cells causes impaired FcgammaR effector functions

21 January 2018

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21 January 2018

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Signal sequences specify the targeting route to the endoplasmic reticulum membrane

21 January 2018

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Recognition of the carboxyl-terminal signal for GPI modification requires translocation of its hydrophobic domain across the ER membrane

21 January 2018

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21 January 2018

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21 January 2018

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Selectivity at the cleavage/attachment site of phosphatidylinositol-glycan anchored membrane proteins is enzymatically determined

21 January 2018

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Biosynthesis of glycosylphosphatidylinositol (GPI)-anchored membrane proteins in intact cells: specific amino acid requirements adjacent to the site of cleavage and GPI attachment

21 January 2018

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Determinants for glycophospholipid anchoring of the Saccharomyces cerevisiae GAS1 protein to the plasma membrane

21 January 2018

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Fusion of sequence elements from non-anchored proteins to generate a fully functional signal for glycophosphatidylinositol membrane anchor attachment

21 January 2018

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21 January 2018

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Requirements for glycosylphosphatidylinositol attachment are similar but not identical in mammalian cells and parasitic protozoa

21 January 2018

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Early lipid intermediates in glycosyl-phosphatidylinositol anchor assembly are synthesized in the ER and located in the cytoplasmic leaflet of the ER membrane bilayer.

21 January 2018

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The GPI anchor of cell-surface proteins is synthesized on the cytoplasmic face of the endoplasmic reticulum.

21 January 2018

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New fluorescent probes reveal that flippase-mediated flip-flop of phosphatidylinositol across the endoplasmic reticulum membrane does not depend on the stereochemistry of the lipid

21 January 2018

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Evidence that the putative COOH-terminal signal transamidase involved in glycosylphosphatidylinositol protein synthesis is present in the endoplasmic reticulum

21 January 2018

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Transfer of glycosyl-phosphatidylinositol membrane anchors to polypeptide acceptors in a cell-free system

21 January 2018

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Glycosyl-phosphatidylinositol anchor attachment in a yeast in vitro system

21 January 2018

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Biosynthesis of phosphatidylinositol-glycan (PI-G)-anchored membrane proteins in cell-free systems: cleavage of the nascent protein and addition of the PI-G moiety depend on the size of the COOH-terminal signal peptide

21 January 2018

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21 January 2018

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Ke 6 gene. Sequence and organization and aberrant regulation in murine polycystic kidney disease

21 January 2018

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COOH-terminal processing of nascent polypeptides by the glycosylphosphatidylinositol transamidase in the presence of hydrazine is governed by the same parameters as glycosylphosphatidylinositol addition

21 January 2018

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Identification of six complementation classes involved in the biosynthesis of glycosylphosphatidylinositol anchors in Saccharomyces cerevisiae.

21 January 2018

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Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins

21 January 2018

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https://api.crossref.org/works/10.1080/09687860600601494

Identification of SPT14/CWH6 as the yeast homologue of hPIG-A, a gene involved in the biosynthesis of GPI anchors

21 January 2018

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https://api.crossref.org/works/10.1080/09687860600601494

MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast

21 January 2018

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Processing and trafficking of Leishmania mexicana GP63. Analysis using GP18 mutants deficient in glycosylphosphatidylinositol protein anchoring

21 January 2018

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Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins

21 January 2018

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Families of cysteine peptidases.

21 January 2018

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MEROPS: the peptidase database.

21 January 2018

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A putative vacuolar processing protease is regulated by ethylene and also during fruit ripening in Citrus fruit

21 January 2018

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Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase

21 January 2018

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Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases

21 January 2018

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Vacuolar processing enzymes are essential for proper processing of seed storage proteins in Arabidopsis thaliana

21 January 2018

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Isolation and analysis of cDNA encoding a precursor of Canavalia ensiformis asparaginyl endopeptidase (legumain).

21 January 2018

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An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation.

21 January 2018

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Endoplasmic reticulum proteins involved in glycosylphosphatidylinositol-anchor attachment: photocrosslinking studies in a cell-free system.

21 January 2018

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Early events in glycosylphosphatidylinositol anchor addition. substrate proteins associate with the transamidase subunit gpi8p

21 January 2018

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Evidence for a role for the Dictyostelium Rap1 in cell viability and the response to osmotic stress

21 January 2018

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Active site determination of Gpi8p, a caspase-related enzyme required for glycosylphosphatidylinositol anchor addition to proteins

21 January 2018

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Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins

21 January 2018

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Molecular cloning of human homolog of yeast GAA1 which is required for attachment of glycosylphosphatidylinositols to proteins1

21 January 2018

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GPI transamidase of Trypanosoma brucei has two previously uncharacterized (trypanosomatid transamidase 1 and 2) and three common subunits

21 January 2018

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Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/09687860600601494

A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase

21 January 2018

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The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p, and Gpi16p

21 January 2018

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PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8

21 January 2018

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Gpi17p does not stably interact with other subunits of glycosylphosphatidylinositol transamidase in Saccharomyces cerevisiae

21 January 2018

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Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

21 January 2018

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Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge

21 January 2018

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Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins

21 January 2018

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The Genome of the African Trypanosome Trypanosoma brucei

21 January 2018

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The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease

21 January 2018

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The genome of the kinetoplastid parasite, Leishmania major

21 January 2018

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Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis

21 January 2018

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10.1080/09687860600601494

21 January 2018

Identifiers

DOI

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14 August 2017

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