Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization (Q36496658)

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English	Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

14 August 2017

Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization (English)

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Europe PubMed Central

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14 August 2017

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Jared T Shaw

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14 August 2017

Jerry E. Chipuk

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Jerry E Chipuk

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Douglas R. Green

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Douglas R Green

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Ann Cassidy-Stone

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14 August 2017

Elena Ingerman

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14 August 2017

Cheng Song

4

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14 August 2017

Choong Yoo

5

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14 August 2017

Tomomi Kuwana

6

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Europe PubMed Central

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14 August 2017

Mark J Kurth

7

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14 August 2017

Jenny E Hinshaw

9

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14 August 2017

Jodi Nunnari

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14 August 2017

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publication date

1 February 2008

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Europe PubMed Central

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14 August 2017

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12

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Developmental Cell

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14 August 2017

14

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14 August 2017

2

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Europe PubMed Central

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14 August 2017

193-204

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Europe PubMed Central

PMC publication ID

14 August 2017

Role of mitochondrial remodeling in programmed cell death in Drosophila melanogaster

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

The machines that divide and fuse mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

A stapled BID BH3 helix directly binds and activates BAX

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Role of Bax and Bak in mitochondrial morphogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Mitochondria: dynamic organelles in disease, aging, and development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Critical dependence of neurons on mitochondrial dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Which came first, the cytochrome c release or the mitochondrial fission?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Dynasore, a cell-permeable inhibitor of dynamin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Mitochondrial dynamics and disease, OPA1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Mitochondrial fusion and fission in mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Mdv1 interacts with assembled dnm1 to promote mitochondrial division

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Dnm1 forms spirals that are structurally tailored to fit mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Disruption of fusion results in mitochondrial heterogeneity and dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Structural basis of mitochondrial tethering by mitofusin complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Apoptosis: giving phosphatidylserine recognition an assist--with a twist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Dynamics of mitochondrial morphology in healthy cells and during apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Mitochondria: releasing power for life and unleashing the machineries of death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Dynamin family of mechanoenzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

The pleitropic drug ABC transporters from Saccharomyces cerevisiae.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Latrunculin alters the actin-monomer subunit interface to prevent polymerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

A human dynamin-related protein controls the distribution of mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

The Bcl-2 protein family: arbiters of cell survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Dynamin self-assembly stimulates its GTPase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Temperature-sensitive yeast mutants defective in mitochondrial inheritance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

30 September 2017

Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

28 June 2018

Mitochondrial fusion intermediates revealed in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

28 June 2018

Mitochondrial disruption in Drosophila apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

21 September 2018

Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

21 September 2018

DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

21 September 2018

Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2267902

21 September 2018

Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18267088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphology of mitochondria during apoptosis: worms-to-beetles in worms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18267088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of mitochondria in apoptosis induction in Caenorhabditis elegans: more than just innocent bystanders?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18267088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18267088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.DEVCEL.2007.11.019

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

ResearchGate publication ID

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