Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension (Q36494495)

14 August 2017

Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension (English)

1 reference

14 August 2017

arterial hypertension

0 references

Iain A Greenwood

13

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Dayue Darrel Duan

10

object named as

Dayue D Duan

0 references

Normand R. Leblanc

14

object named as

Normand Leblanc

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Cherie A. Singer

11

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Maria L. Valencik

12

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author name string

Abigail S Forrest

1

1 reference

14 August 2017

Talia C Joyce

2

1 reference

14 August 2017

Marissa L Huebner

3

1 reference

14 August 2017

Ramon J Ayon

4

1 reference

14 August 2017

Michael Wiwchar

5

1 reference

14 August 2017

John Joyce

6

1 reference

14 August 2017

Natalie Freitas

7

1 reference

14 August 2017

Alison J Davis

8

1 reference

14 August 2017

Linda Ye

9

1 reference

14 August 2017

language of work or name

1 reference

3 October 2012

1 reference

American Journal of Physiology - Cell Physiology

14 August 2017

1 reference

14 August 2017

303

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14 August 2017

12

1 reference

14 August 2017

C1229-43

1 reference

Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Activity of Ca2 ‐Activated Cl− Channels Contributes to Regulating Receptor‐ and Store‐Operated Ca2 Entry in Human Pulmonary Artery Smooth Muscle Cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

TMEM16A channels generate Ca2 -activated Cl− currents in cerebral artery smooth muscle cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Altered expression of Ano1 variants in human diabetic gastroparesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Expression profile and protein translation of TMEM16A in murine smooth muscle

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

TMEM16A/anoctamin 1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Chronic hypoxia augments depolarization-induced Ca2 sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Regulation of TMEM16A chloride channel properties by alternative splicing

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Phosphorylation alters the pharmacology of Ca(2 )-activated Cl channels in rabbit pulmonary arterial smooth muscle cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Complex phosphatase regulation of Ca2 -activated Cl- currents in pulmonary arterial smooth muscle cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Anoctamin/TMEM16 family members are Ca2 -activated Cl- channels

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Expression cloning of TMEM16A as a calcium-activated chloride channel subunit

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Upregulation of vascular calcium channels in neonatal piglets with hypoxia-induced pulmonary hypertension

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

TMEM16A confers receptor-activated calcium-dependent chloride conductance

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

The transmembrane protein TMEM16A is required for normal development of the murine trachea

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

How valid are animal models to evaluate treatments for pulmonary hypertension?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Mechanism of the inhibition of Ca2 -activated Cl- currents by phosphorylation in pulmonary arterial smooth muscle cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

30 September 2017

Ion channels and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Regulation of calcium-activated chloride channels in smooth muscle cells: a complex picture is emerging

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

ClC-3 chloride channel is upregulated by hypertrophy and inflammation in rat and canine pulmonary artery

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Calcineurin Aalpha but not Abeta augments ICl(Ca) in rabbit pulmonary artery smooth muscle cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Chloride channels and their functional roles in smooth muscle tone in the vasculature

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Characteristics and physiological role of the Ca(2 )-activated Cl- conductance in smooth muscle

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Comparison of the effects of fenamates on Ca-activated chloride and potassium currents in rabbit portal vein smooth muscle cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Action of niflumic acid on evoked and spontaneous calcium-activated chloride and potassium currents in smooth muscle cells from rabbit portal vein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Lung angiotensin converting enzyme activity in rats with pulmonary hypertension

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Arterial changes in Crotalaria spectabilis-induced pulmonary hypertension in rats

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Development of pulmonary arterial changes in rats fed Crotalaria spectabilis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Fibrin thrombosis in monocrotaline pyrrole-induced cor pulmonale in rats

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

A minimal isoform of the TMEM16A protein associated with chloride channel activity.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Noninvasive assessment of murine pulmonary arterial pressure: validation and application to models of pulmonary hypertension

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca2 channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Characterization of an outward potassium current in canine jejunal circular smooth muscle and its activation by fenamates.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Positive regulation by chloride channel blockers of IsK channels expressed in Xenopus oocytes.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Endothelial injury and vascular reactivity in monocrotaline pulmonary hypertension.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Altered pulmonary vascular smooth muscle responsiveness in monocrotaline-induced pulmonary hypertension

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Downregulation of TMEM16A calcium-activated chloride channel contributes to cerebrovascular remodeling during hypertension by promoting basilar smooth muscle cell proliferation.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Pulmonary artery acceleration time provides an accurate estimate of systolic pulmonary arterial pressure during transthoracic echocardiography

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Intricate interaction between store-operated calcium entry and calcium-activated chloride channels in pulmonary artery smooth muscle cells

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Regulation of proliferation and membrane potential by chloride currents in rat pulmonary artery smooth muscle cells.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Chloride channels and alpha1-adrenoceptor-mediated pulmonary artery smooth muscle contraction: effect of pulmonary hypertension

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Advancing therapy for pulmonary arterial hypertension: can animal models help?

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Activation of the right ventricular endothelin (ET) system in the monocrotaline model of pulmonary hypertension: response to chronic ETA receptor blockade.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Serial noninvasive assessment of progressive pulmonary hypertension in a rat model

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Differential regulation of Ca(2 )-activated Cl(-) currents in rabbit arterial and portal vein smooth muscle cells by Ca(2 )-calmodulin-dependent kinase

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Potentiation of large conductance KCa channels by niflumic, flufenamic, and mefenamic acids

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Short-Term Administration of a Cell-Permeable Caveolin-1 Peptide Prevents the Development of Monocrotaline-Induced Pulmonary Hypertension and Right Ventricular Hypertrophy

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3532492

Chronic hypoxia induces nonreversible right ventricle dysfunction and dysplasia in rats

4 December 2018

1 reference

12 December 2020

Alterations in pulmonary alveoli after a single injection of monocrotaline

1 reference

12 December 2020

The effect of a pyrrolizidine alkaloid, monocrotaline, and a pyrrole, dehydroretronecine, on the biochemical functions of the pulmonary endothelium

1 reference

12 December 2020

Vascular hyperresponsiveness in perfused lungs from monocrotaline-treated rats

1 reference

12 December 2020

Role of calcium-activated chloride current in regulating pulmonary vasomotor tone

1 reference

12 December 2020

Pulmonary vascular responses induced by the pyrrolizidine alkaloid, monocrotaline, in rats

1 reference

12 December 2020

Flufenamic acid, mefenamic acid and niflumic acid inhibit single nonselective cation channels in the rat exocrine pancreas

1 reference

12 December 2020

Renal and pulmonary alterations induced in rats by a single injection of monocrotaline

1 reference

12 December 2020

Attenuated K channel gene transcription in primary pulmonary hypertension

1 reference

12 December 2020

Activation of Ca2 -activated Cl- channels by store-operated Ca2 entry in arterial smooth muscle cells does not require reverse-mode Na /Ca2 exchange

1 reference

12 December 2020

Chronic hypoxia-induced upregulation of Ca2 -activated Cl- channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity

1 reference

12 December 2020

Monocrotaline-lnduced Pulmonary Endothelial Dysfunction in Rats

1 reference

12 December 2020

Role of Ca2 - and swelling-activated Cl- channels in alpha1-adrenoceptor-mediated tone in pressurized rabbit mesenteric arterioles

1 reference

12 December 2020

10.1152/AJPCELL.00044.2012

Identifiers

DOI

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

23034390

1 reference