BRCA1 and BRCA2: chemosensitivity, treatment outcomes and prognosis (Q36493340)

14 August 2017

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title

BRCA1 and BRCA2: chemosensitivity, treatment outcomes and prognosis (English)

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14 August 2017

author

William David Foulkes

object named as

William D Foulkes

series ordinal

1

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language of work or name

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1 January 2006

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14 August 2017

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14 August 2017

volume

5

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14 August 2017

issue

2

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14 August 2017

page(s)

135-142

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Clinico-pathological characteristics of BRCA1- and BRCA2-related breast cancer.

14 August 2017

cites work

1 reference

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TP53 gene mutations predict the response to neoadjuvant treatment with 5-fluorouracil and mitomycin in locally advanced breast cancer

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MYC is amplified in BRCA1-associated breast cancers

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Increased expression of BRCA1 mRNA predicts favorable response to anthracycline-containing chemotherapy in breast cancers

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The effect of loss of Brca1 on the sensitivity to anticancer agents in p53-deficient cells.

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Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

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Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival

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A single-nucleotide polymorphism in the RAD51 gene modifies breast cancer risk in BRCA2 carriers, but not in BRCA1 carriers or noncarriers

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Inactivation of BRCA1 and BRCA2 in ovarian cancer

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The contribution of inherited factors to the clinicopathological features and behavior of breast cancer

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Core biopsies can be used to distinguish differences in expression profiling by cDNA microarrays

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Molecular Portraits and 70-Gene Prognosis Signature Are Preserved throughout the Metastatic Process of Breast Cancer

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Preoperative therapy in breast cancer: lessons from the treatment of locally advanced disease

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Germline BRCA1/2 mutations and p27(Kip1) protein levels independently predict outcome after breast cancer.

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Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

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12 December 2020

Chemosensitivity and radiosensitivity profiles of four new human epithelial ovarian cancer cell lines exhibiting genetic alterations in BRCA2, TGFbeta-RII, KRAS2, TP53 and/or CDNK2A.

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12 December 2020

Effect of BRCA Mutations on the Length of Survival in Epithelial Ovarian Tumors

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Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors

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12 December 2020

Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells

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BRCA1 Facilitates Stress-induced Apoptosis in Breast and Ovarian Cancer Cell Lines

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Clinicopathologic features of BRCA-linked and sporadic ovarian cancer

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Gene expression profiling predicts clinical outcome of breast cancer

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

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12 December 2020

Low expression of bcl-2 in Brca1-associated breast cancers

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Role of BRCA1 in cellular resistance to paclitaxel and ionizing radiation in an ovarian cancer cell line carrying a defective BRCA1

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12 December 2020

Basal-like breast carcinomas: clinical outcome and response to chemotherapy

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Monoclonal marker that predicts early recurrence of breast cancer

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AlphaB-crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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Genetic counselling for familial breast and ovarian cancer in Ontario

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Repeated observation of breast tumor subtypes in independent gene expression data sets

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Absence of CCND1 gene amplification in breast tumours of BRCA1 mutation carriers

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12 December 2020

Involvement of Brca2 in DNA repair

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12 December 2020

Tumor classification using phylogenetic methods on expression data

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12 December 2020

Are BRCA1- and BRCA2-related breast cancers associated with increased mortality?

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12 December 2020

In search of the tumour-suppressor functions of BRCA1 and BRCA2

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12 December 2020

Tracing the network connecting BRCA and Fanconi anaemia proteins

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Frequent disease progression and early recurrence in patients with familial ovarian cancer primarily treated with paclitaxel and cis- or carboplatin (preliminary report)

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12 December 2020

Ovarian cancer survival in Ashkenazi Jewish patients with BRCA1 and BRCA2 mutations

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12 December 2020

The prognostic implication of the basal-like (cyclin E high/p27 low/p53 /glomeruloid-microvascular-proliferation ) phenotype of BRCA1-related breast cancer

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12 December 2020

Breast cancer classification and prognosis based on gene expression profiles from a population-based study

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12 December 2020

Survival analysis in familial ovarian cancer, a case control study

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12 December 2020

A significant response to neoadjuvant chemotherapy in BRCA1/2 related breast cancer

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12 December 2020

The nuclear transcription factor kappaB/bcl-2 pathway correlates with pathologic complete response to doxorubicin-based neoadjuvant chemotherapy in human breast cancer.

1 reference

12 December 2020

Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer.

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12 December 2020

Disruption of the expected positive correlation between breast tumor size and lymph node status in BRCA1-related breast carcinoma

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12 December 2020

Biallelic inactivation of BRCA2 in Fanconi anemia

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12 December 2020

TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: distinctive spectrum and structural distribution.

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12 December 2020

A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers

1 reference

12 December 2020

Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome

1 reference

12 December 2020

Biological and prognostic significance of stratified epithelial cytokeratins in infiltrating ductal breast carcinomas

1 reference

12 December 2020

Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance

1 reference

12 December 2020

Sensitivity of BRCA-1-Related Breast Cancer to Neoadjuvant Chemotherapy: Practical Implications

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12 December 2020

Improved survival in women with BRCA-associated ovarian carcinoma

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12 December 2020

Revisiting the rodent repairadox

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12 December 2020

Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations

1 reference

12 December 2020

ERBB2, TBX2, RPS6KB1, and MYC alterations in breast tissues of BRCA1 and BRCA2 mutation carriers

1 reference

12 December 2020

BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis

1 reference

12 December 2020

BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo

1 reference

12 December 2020

Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation

1 reference

12 December 2020

The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2.

1 reference

12 December 2020

BRCA1 and BRCA2: 1994 and beyond

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12 December 2020

BRCA1 up-regulation is associated with repair-mediated resistance to cis-diamminedichloroplatinum(II).

1 reference

12 December 2020

Survival in familial, BRCA1-associated, and BRCA2-associated epithelial ovarian cancer. United Kingdom Coordinating Committee for Cancer Research (UKCCCR) Familial Ovarian Cancer Study Group

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12 December 2020

Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics

1 reference

12 December 2020

DNA double-strand breaks: signaling, repair and the cancer connection

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12 December 2020

Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer

1 reference

12 December 2020

Cytogenetic alterations and cytokeratin expression patterns in breast cancer: integrating a new model of breast differentiation into cytogenetic pathways of breast carcinogenesis.

1 reference

12 December 2020

Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas.

1 reference

12 December 2020

Gene-Expression Profiles in Hereditary Breast Cancer

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12 December 2020

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

1 reference

12 December 2020

The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin

1 reference

12 December 2020

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

1 reference

12 December 2020

A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers

1 reference

12 December 2020

Breast cancer molecular subtypes respond differently to preoperative chemotherapy

1 reference

12 December 2020

The pathology of familial breast cancer: histological features of cancers in families not attributable to mutations in BRCA1 or BRCA2

1 reference

12 December 2020

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

1 reference

12 December 2020

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12 December 2020

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

1 reference

12 December 2020

CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies

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12 December 2020

Glomeruloid microvascular proliferation is associated with p53 expression, germline BRCA1 mutations and an adverse outcome following breast cancer

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12 December 2020

Hereditary breast cancer

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12 December 2020

Impact of BRCA1/BRCA2 counseling and testing on newly diagnosed breast cancer patients

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12 December 2020

A combined analysis of outcome following breast cancer: differences in survival based on BRCA1/BRCA2 mutation status and administration of adjuvant treatment

1 reference

12 December 2020

BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells

1 reference

12 December 2020

10.1007/S10689-005-2832-5

Identifiers

DOI

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14 August 2017

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