Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A. (Q36485104)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23213206 AND SRC:MED&resulttype=core&format=json

19 February 2020

title

Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A (English)

1 reference

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19 February 2020

5

1 reference

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19 February 2020

Itai Benhar

8

1 reference

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19 February 2020

author name string

Ronit Mazor

1

1 reference

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19 February 2020

Aaron N Vassall

2

1 reference

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19 February 2020

Jaime A Eberle

3

1 reference

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19 February 2020

Richard Beers

4

1 reference

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19 February 2020

David J Venzon

6

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19 February 2020

Kwong Y Tsang

7

1 reference

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19 February 2020

Ira Pastan

9

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19 February 2020

language of work or name

English

0 references

publication date

3 December 2012

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

19 February 2020

published in

1 reference

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19 February 2020

volume

109

1 reference

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19 February 2020

issue

51

1 reference

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19 February 2020

page(s)

E3597-603

1 reference

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Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes

19 February 2020

cites work

1 reference

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Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

Treatment of Hematologic Malignancies with Immunotoxins and Antibody-Drug Conjugates

30 September 2017

1 reference

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Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

Molecular determinants of T cell epitope recognition to the common Timothy grass allergen

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

Immunoproteomic identification of human T cell antigens of Mycobacterium tuberculosis that differentiate healthy contacts from tuberculosis patients

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

Phase I trial of continuous infusion anti-mesothelin recombinant immunotoxin SS1P.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

Dealing with immunogenicity of biologicals: assessment and clinical relevance

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

Scientific and regulatory considerations on the immunogenicity of biologics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

De-immunization of therapeutic proteins by T-cell epitope modification.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

A beta-lactamase with reduced immunogenicity for the targeted delivery of chemotherapeutics using antibody-directed enzyme prodrug therapy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

The development of a modified human IFN-alpha2b linked to the Fc portion of human IgG1 as a novel potential therapeutic for the treatment of hepatitis C virus infection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

Recombinant immunotoxins in the treatment of cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

Several common HLA-DR types share largely overlapping peptide binding repertoires

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

T cell-dependent B cell activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

The functions of antigen recognition in T cell-dependent B cell activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529021

Rationally engineered therapeutic proteins with reduced immunogenicity

30 September 2017

1 reference

https://api.crossref.org/works/10.1073/PNAS.1218138109

T cell recognition patterns of immunodominant cytomegalovirus antigens in primary and persistent infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1218138109

ProPred: prediction of HLA-DR binding sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1218138109

Monitoring of cellular responses after vaccination against tetanus toxoid: comparison of the measurement of IFN-gamma production by ELISA, ELISPOT, flow cytometry and real-time PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1218138109

Elimination of an immunodominant CD4 T cell epitope in human IFN-beta does not result in an in vivo response directed at the subdominant epitope

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1218138109

Characterization of the B cell epitopes associated with a truncated form of Pseudomonas exotoxin (PE38) used to make immunotoxins for the treatment of cancer patients

21 January 2018

1 reference

12 December 2020

Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers

1 reference

12 December 2020

Immunogenicity of biologic therapies—we need tolerance

1 reference

12 December 2020

Elimination of a human T-cell region in staphylokinase by T-cell screening and computer modeling

1 reference

12 December 2020

Foreignness as a matter of degree: the relative immunogenicity of peptide/MHC ligands

1 reference

12 December 2020

Vaccination in humans generates broad T cell cytokine responses

1 reference

12 December 2020

Immunodominance: a single amino acid substitution within an antigenic site alters intramolecular selection of T cell determinants

1 reference

12 December 2020

Identification of a putative motif for binding of peptides to HLA-DQ2

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1218138109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23213206 AND SRC:MED&resulttype=core&format=json

19 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23213206 AND SRC:MED&resulttype=core&format=json

19 February 2020

PubMed publication ID

23213206

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23213206 AND SRC:MED&resulttype=core&format=json