Post-translational protein modification by O-linked N-acetyl-glucosamine: its role in mediating the adverse effects of diabetes on the heart. (Q36484390)

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English	Post-translational protein modification by O-linked N-acetyl-glucosamine: its role in mediating the adverse effects of diabetes on the heart.	scientific article

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13 February 2020

Post-translational protein modification by O-linked N-acetyl-glucosamine: its role in mediating the adverse effects of diabetes on the heart (English)

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13 February 2020

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Jennifer L McLarty

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13 February 2020

John C Chatham

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11 August 2012

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13 February 2020

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13 February 2020

Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-β-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytes

1 reference

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30 September 2017

Cardiac O-GlcNAcylation blunts autophagic signaling in the diabetic heart

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30 September 2017

O-GlcNAc signaling is essential for NFAT-mediated transcriptional reprogramming during cardiomyocyte hypertrophy

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30 September 2017

Protein O-GlcNAcylation: A critical regulator of the cellular response to stress.

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30 September 2017

Epigenetic memory in mammals

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30 September 2017

The roles of O-linked β-N-acetylglucosamine in cardiovascular physiology and disease

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30 September 2017

GlcNAcylation of histone H2B facilitates its monoubiquitination

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30 September 2017

Protein O-linked β-N-acetylglucosamine: a novel effector of cardiomyocyte metabolism and function

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30 September 2017

Acute regulation of cardiac metabolism by the hexosamine biosynthesis pathway and protein O-GlcNAcylation.

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30 September 2017

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

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30 September 2017

Regulation of mitochondrial morphology and function by O-GlcNAcylation in neonatal cardiac myocytes

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30 September 2017

Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone code

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30 September 2017

O-linked β-N-acetylglucosamine transferase is indispensable in the failing heart.

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30 September 2017

Activation of the hexosamine biosynthesis pathway and protein O-GlcNAcylation modulate hypertrophic and cell signaling pathways in cardiomyocytes from diabetic mice

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30 September 2017

O-GlcNAc signaling in the cardiovascular system

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30 September 2017

Site-specific interplay between O-GlcNAcylation and phosphorylation in cellular regulation

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30 September 2017

Inhibition of histone deacetylase protects the retina from ischemic injury

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30 September 2017

Epigenetic mechanisms in the development of type 2 diabetes

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30 September 2017

Increased enzymatic O-GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucose

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30 September 2017

Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc

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30 September 2017

Bcl-2 family members: dual regulators of apoptosis and autophagy

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30 September 2017

Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity

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30 September 2017

Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase

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30 September 2017

Histone deacetylase inhibitors: a novel class of therapeutic agents in diabetic nephropathy

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30 September 2017

Cardiac substrate uptake and metabolism in obesity and type-2 diabetes: Role of sarcolemmal substrate transporters

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O-GlcNAc integrates the proteasome and transcriptome to regulate nuclear hormone receptors

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30 September 2017

Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1

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30 September 2017

Cell signaling, the essential role of O-GlcNAc!

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30 September 2017

Genome-wide RNAi screen of Ca(2 ) influx identifies genes that regulate Ca(2 ) release-activated Ca(2 ) channel activity

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30 September 2017

Amplification of CRAC current by STIM1 and CRACM1 (Orai1)

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30 September 2017

Disrupting the enzyme complex regulating O-GlcNAcylation blocks signaling and development

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30 September 2017

STIM1 is a Ca2 sensor that activates CRAC channels and migrates from the Ca2 store to the plasma membrane

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30 September 2017

Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.

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30 September 2017

Glucosamine inhibits angiotensin II-induced cytoplasmic Ca2 elevation in neonatal cardiomyocytes via protein-associated O-linked N-acetylglucosamine

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30 September 2017

STIM is a Ca2 sensor essential for Ca2 -store-depletion-triggered Ca2 influx

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30 September 2017

STIM1, an essential and conserved component of store-operated Ca2 channel function

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30 September 2017

Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities

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30 September 2017

Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications

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30 September 2017

Cardiomyocyte calcium and calcium/calmodulin-dependent protein kinase II: friends or foes?

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30 September 2017

Glycation, inflammation, and RAGE: a scaffold for the macrovascular complications of diabetes and beyond

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30 September 2017

Sp1 and Sp3 transcription factors are required for trans-activation of the human SERCA2 promoter in cardiomyocytes

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Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning

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30 September 2017

Contraction-Induced Fatty Acid Translocase/CD36 Translocation in Rat Cardiac Myocytes Is Mediated Through AMP-Activated Protein Kinase Signaling

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30 September 2017

Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression

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30 September 2017

New insights into long-chain fatty acid uptake by heart muscle: a crucial role for fatty acid translocase/CD36

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30 September 2017

Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

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30 September 2017

Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death.

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30 September 2017

Translating the Histone Code

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30 September 2017

O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability

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30 September 2017

The neuron-restrictive silencer element-neuron-restrictive silencer factor system regulates basal and endothelin 1-inducible atrial natriuretic peptide gene expression in ventricular myocytes

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30 September 2017

Calcineurin and beyond: cardiac hypertrophic signaling.

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30 September 2017

Transmembrane helix M6 in sarco(endo)plasmic reticulum Ca(2 )-ATPase forms a functional interaction site with phospholamban. Evidence for physical interactions at other sites

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30 September 2017

Phospholamban inhibitory function is activated by depolymerization

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30 September 2017

Role of the glucosamine pathway in fat-induced insulin resistance

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30 September 2017

Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats

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30 September 2017

Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue

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30 September 2017

The repressor element 1-silencing transcription factor regulates heart-specific gene expression using multiple chromatin-modifying complexes

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28 June 2018

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28 June 2018

Depressed PKA activity contributes to impaired SERCA function and is linked to the pathogenesis of glucose-induced cardiomyopathy

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28 June 2018

Enhanced O-GlcNAc protein modification is associated with insulin resistance in GLUT1-overexpressing muscles

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28 June 2018

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28 June 2018

Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy

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21 September 2018

Adenovirus-mediated overexpression of O-GlcNAcase improves contractile function in the diabetic heart

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21 September 2018

Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats

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21 September 2018

Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress. A survival response of mammalian cells

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21 September 2018

Hexosamine pathway is responsible for inhibition by diabetes of phenylephrine-induced inotropy

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21 September 2018

Fatty acid translocase/CD36 deficiency does not energetically or functionally compromise hearts before or after ischemia

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21 September 2018

Diabetes and the accompanying hyperglycemia impairs cardiomyocyte calcium cycling through increased nuclear O-GlcNAcylation

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21 September 2018

Palmitate-induced activation of the hexosamine pathway in human myotubes: increased expression of glutamine:fructose-6-phosphate aminotransferase

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21 September 2018

Hyperglycemia inhibits capacitative calcium entry and hypertrophy in neonatal cardiomyocytes

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21 September 2018

High glucose and insulin promote O-GlcNAc modification of proteins, including alpha-tubulin

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21 September 2018

Capacitative calcium entry contributes to nuclear factor of activated T-cells nuclear translocation and hypertrophy in cardiomyocytes

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21 September 2018

Reciprocity between O-GlcNAc and O-phosphate on the carboxyl terminal domain of RNA polymerase II.

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21 September 2018

Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1

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4 December 2018

Body mass index, abdominal adiposity and blood pressure: consistency of their association across developing and developed countries

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4 December 2018

Increased congestive heart failure after myocardial infarction of modest extent in patients with diabetes mellitus

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myocardial cell death in human diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22985933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22985933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes rapidly induces contractile dysfunctions in isolated ventricular myocytes

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https://pubmed.ncbi.nlm.nih.gov/22985933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholamban regulation of cardiac sarcoplasmic reticulum (Ca(2 )-Mg2 )-ATPase. Mechanism of regulation and site of monoclonal antibody interaction

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https://pubmed.ncbi.nlm.nih.gov/22985933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc

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https://pubmed.ncbi.nlm.nih.gov/22985933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino acids Lys-Asp-Asp-Lys-Pro-Val402 in the Ca(2 )-ATPase of cardiac sarcoplasmic reticulum are critical for functional association with phospholamban.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22985933

12 December 2020

based on heuristic

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High extracellular glucose impairs cardiac E-C coupling in a glycosylation-dependent manner

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https://pubmed.ncbi.nlm.nih.gov/22985933

12 December 2020

based on heuristic

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Identifiers

10.1016/J.LFS.2012.08.006

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22985933 AND SRC:MED&resulttype=core&format=json

13 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22985933 AND SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22985933 AND SRC:MED&resulttype=core&format=json

13 February 2020

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