Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub. (Q36483801)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23169622 AND SRC:MED&resulttype=core&format=json

18 February 2020

title

Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub (English)

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18 February 2020

1

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18 February 2020

5

Niels Galjart

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18 February 2020

author name string

Jiyoti Verma-Gaur

2

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18 February 2020

Ali Torkamani

3

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18 February 2020

Ann J Feeney

4

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18 February 2020

Michael S Krangel

6

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18 February 2020

language of work or name

English

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publication date

19 November 2012

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Proceedings of the National Academy of Sciences of the United States of America

18 February 2020

published in

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18 February 2020

volume

109

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18 February 2020

issue

50

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18 February 2020

page(s)

E3493-502

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Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement

18 February 2020

cites work

1 reference

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Tcra enhancer activation by inducible transcription factors downstream of pre-TCR signaling.

30 September 2017

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CTCF-cohesin complex: architect of chromatin structure regulates V(D)J rearrangement

30 September 2017

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Two forms of loops generate the chromatin conformation of the immunoglobulin heavy-chain gene locus

30 September 2017

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A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation

30 September 2017

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Long-distance regulation of fetal V(δ) gene segment TRDV4 by the Tcrd enhancer.

30 September 2017

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30 September 2017

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CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells

30 September 2017

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A multifunctional element in the mouse Igκ locus that specifies repertoire and Ig loci subnuclear location.

30 September 2017

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Recombination centres and the orchestration of V(D)J recombination

30 September 2017

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The distal V(H) gene cluster of the Igh locus contains distinct regulatory elements with Pax5 transcription factor-dependent activity in pro-B cells

30 September 2017

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A Barrier-Type Insulator Forms a Boundary between Active and Inactive Chromatin at the Murine TCRβ Locus

30 September 2017

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Distinct contracted conformations of the Tcra/Tcrd locus during Tcra and Tcrd recombination

30 September 2017

1 reference

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The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.

30 September 2017

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Cohesin: its roles and mechanisms

30 September 2017

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CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus

30 September 2017

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Chromatin architecture and the generation of antigen receptor diversity

30 September 2017

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CTCF: master weaver of the genome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

CTCF regulates cell cycle progression of alphabeta T cells in the thymus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop

30 September 2017

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CTCF physically links cohesin to chromatin

30 September 2017

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Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

30 September 2017

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The 3D structure of the immunoglobulin heavy-chain locus: implications for long-range genomic interactions.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

Cohesins functionally associate with CTCF on mammalian chromosome arms

30 September 2017

1 reference

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Cohesin mediates transcriptional insulation by CCCTC-binding factor

30 September 2017

1 reference

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CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators

30 September 2017

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Genetics and epigenetics of the multifunctional protein CTCF.

30 September 2017

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Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination

30 September 2017

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30 September 2017

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High-resolution profiling of histone methylations in the human genome

30 September 2017

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Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome

30 September 2017

1 reference

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Analysis of the H19ICR insulator

30 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus

30 September 2017

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CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2

30 September 2017

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Biochemistry of V(D)J recombination.

30 September 2017

1 reference

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Regulation of TCR delta and alpha repertoires by local and long-distance control of variable gene segment chromatin structure

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

Enhancer control of local accessibility to V(D)J recombinase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

CTCF-binding elements mediate control of V(D)J recombination

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

Cutting edge: developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

The beta-globin nuclear compartment in development and erythroid differentiation

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

CD3 epsilon-mediated signals rescue the development of CD4 CD8 thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528579

The DNA-Binding Protein CTCF Limits Proximal Vκ Recombination and Restricts κ Enhancer Interactions to the Immunoglobulin κ Light Chain Locus

21 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073/PNAS.1214131109

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated

21 January 2018

1 reference

12 December 2020

Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation

1 reference

12 December 2020

Function of the TCR alpha enhancer in alphabeta and gammadelta T cells

1 reference

12 December 2020

Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1214131109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23169622 AND SRC:MED&resulttype=core&format=json

18 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23169622 AND SRC:MED&resulttype=core&format=json

18 February 2020

PubMed publication ID

23169622

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23169622 AND SRC:MED&resulttype=core&format=json