Mutated but Not Deleted Ovine PrP(C) N-Terminal Polybasic Region Strongly Interferes with Prion Propagation in Transgenic Mice (Q36481434)

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1 March 2020

title

Mutated but Not Deleted Ovine PrP(C) N-Terminal Polybasic Region Strongly Interferes with Prion Propagation in Transgenic Mice (English)

1 reference

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1 March 2020

0 references

14

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1 March 2020

author name string

Manal Khalifé

1

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1 March 2020

Fabienne Reine

2

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1 March 2020

Sophie Paquet-Fifield

3

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1 March 2020

Johan Castille

4

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1 March 2020

Laetitia Herzog

5

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1 March 2020

Marthe Vilotte

6

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1 March 2020

Mohammed Moudjou

7

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1 March 2020

Katayoun Moazami-Goudarzi

8

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1 March 2020

Samira Makhzami

9

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1 March 2020

Bruno Passet

10

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1 March 2020

Olivier Andréoletti

11

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1 March 2020

Didier Vilette

12

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1 March 2020

Hubert Laude

13

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1 March 2020

Jean-Luc Vilotte

15

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1 March 2020

language of work or name

English

0 references

publication date

25 November 2015

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1 March 2020

1 reference

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1 March 2020

volume

90

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1 March 2020

issue

3

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1 March 2020

page(s)

1638-1646

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The prion protein is critical for DNA repair and cell survival after genotoxic stress

1 March 2020

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The N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc).

30 September 2017

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Prionemia and leukocyte-platelet-associated infectivity in sheep transmissible spongiform encephalopathy models.

30 September 2017

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A nine amino acid domain is essential for mutant prion protein toxicity

30 September 2017

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Dissociation of Infectivity from Seeding Ability in Prions with Alternate Docking Mechanism

30 September 2017

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Atypical/Nor98 Scrapie Infectivity in Sheep Peripheral Tissues

30 September 2017

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Review: contribution of transgenic models to understanding human prion disease.

30 September 2017

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Brain transcriptional stability upon prion protein-encoding gene invalidation in zygotic or adult mouse

30 September 2017

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Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues

30 September 2017

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The physical relationship between infectivity and prion protein aggregates is strain-dependent

30 September 2017

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Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependent

30 September 2017

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Prion protein region 23-32 interacts with tubulin and inhibits microtubule assembly

30 September 2017

1 reference

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Identifying key components of the PrPC-PrPSc replicative interface

30 September 2017

1 reference

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Prion agent diversity and species barrier.

30 September 2017

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A general model of prion strains and their pathogenicity

30 September 2017

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Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein

30 September 2017

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Lethal recessive myelin toxicity of prion protein lacking its central domain

30 September 2017

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Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis

30 September 2017

1 reference

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A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes

30 September 2017

1 reference

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Screening of 145 anti-PrP monoclonal antibodies for their capacity to inhibit PrPSc replication in infected cells.

30 September 2017

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The genetics of scrapie in sheep and goats

30 September 2017

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Motif-grafted antibodies containing the replicative interface of cellular PrP are specific for PrPSc

30 September 2017

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The mechanism of internalization of glycosylphosphatidylinositol-anchored prion protein

30 September 2017

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Cell-surface prion protein interacts with glycosaminoglycans

30 September 2017

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Markedly increased susceptibility to natural sheep scrapie of transgenic mice expressing ovine prp.

30 September 2017

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Interactions between prion protein isoforms: the kiss of death?

30 September 2017

1 reference

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Ex vivo propagation of infectious sheep scrapie agent in heterologous epithelial cells expressing ovine prion protein

30 September 2017

1 reference

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Identification of two prion protein regions that modify scrapie incubation time

30 September 2017

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30 September 2017

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Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

30 September 2017

1 reference

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Proline motifs in peptides and their biological processing

30 September 2017

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The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

30 September 2017

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Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice

28 June 2018

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Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions

28 June 2018

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The sequential development of the brain lesion of scrapie in three strains of mice

28 June 2018

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Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters

28 June 2018

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Toward molecular dissection of PrPC-PrPSc interactions

28 June 2018

1 reference

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Regional heterogeneity of cellular prion protein isoforms in the mouse brain

21 September 2018

1 reference

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Phenotyping of protein-prion (PrPsc)-accumulating cells in lymphoid and neural tissues of naturally scrapie-affected sheep by double-labeling immunohistochemistry

21 September 2018

1 reference

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Spatial and temporal down-regulation of transgene expression using the TRSID-silencer in mice: application to Prnp

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26608316

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Marked influence of the route of infection on prion strain apparent phenotype in a scrapie transgenic mouse model

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26608316

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Prion proteins from susceptible and resistant sheep exhibit some distinct cell biological features

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26608316

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/JVI.02805-15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26608316 AND SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26608316 AND SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

26608316

1 reference