The podocyte's response to injury: role in proteinuria and glomerulosclerosis (Q36474870)

14 August 2017

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title

The podocyte's response to injury: role in proteinuria and glomerulosclerosis (English)

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14 August 2017

Shankland SJ

1

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14 August 2017

language of work or name

English

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publication date

10 May 2006

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14 August 2017

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14 August 2017

volume

69

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14 August 2017

issue

12

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14 August 2017

page(s)

2131-2147

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Cell cycle regulatory proteins in glomerular disease

14 August 2017

cites work

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Is podocyte shape controlled by the dystroglycan complex?

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Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines.

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Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis

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Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis

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7 January 2021

Nephrin is specifically located at the slit diaphragm of glomerular podocytes

1 reference

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7 January 2021

Podocin localizes in the kidney to the slit diaphragm area

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7 January 2021

Interaction with podocin facilitates nephrin signaling

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7 January 2021

Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin

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7 January 2021

CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain

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7 January 2021

CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere

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7 January 2021

NEPH1 defines a novel family of podocin interacting proteins

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7 January 2021

Signaling at the slit diaphragm

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7 January 2021

A novel protein, densin, expressed by glomerular podocytes

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7 January 2021

Identification and characterization of podocalyxin--the major sialoprotein of the renal glomerular epithelial cell

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7 January 2021

Podoplanin, a novel 43-kDa membrane protein, controls the shape of podocytes

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7 January 2021

Expression of agrin, dystroglycan, and utrophin in normal renal tissue and in experimental glomerulopathies

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7 January 2021

Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome

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7 January 2021

Molecular pathomechanisms of membranous nephropathy: from Heymann nephritis to alloimmunization

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7 January 2021

Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathies

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7 January 2021

CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility

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7 January 2021

NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome

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7 January 2021

A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis

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7 January 2021

TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function

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7 January 2021

Recent progress in HIV-associated nephropathy

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7 January 2021

Podocyte loss and progressive glomerular injury in type II diabetes

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https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Activation of a local tissue angiotensin system in podocytes by mechanical strain

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

An electron microscope study of the glomerulus in nephrosis, glomerulonephritis, and lupus erythematosus

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https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Structural basis for reduced glomerular filtration capacity in nephrotic humans

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Re-evaluation of foot process effacement in acute puromycin aminonucleoside nephrosis

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https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Podocyte process effacement in vivo

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Nephritogenic mAb 5-1-6 is directed at the extracellular domain of rat nephrin

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https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Podocytes are firmly attached to glomerular basement membrane in kidneys with heavy proteinuria

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

The number of podocyte slit diaphragms is decreased in minimal change nephrotic syndrome.

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Podocyte foot process effacement is not correlated with the level of proteinuria in human glomerulopathies

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Glomerular podocytes and adhesive interaction with glomerular basement membrane.

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Actin Filament Organization of Foot Processes in Rat Podocytes

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Mice deficient in alpha-actinin-4 have severe glomerular disease

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Focal and segmental glomerulosclerosis in mice with podocyte-specific expression of mutant alpha-actinin-4

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

FAT is a component of glomerular slit diaphragms

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Regulation of adhesive interaction between podocytes and glomerular basement membrane

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Podocyte flattening and disorder of glomerular basement membrane are associated with splitting of dystroglycan-matrix interaction

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Adhesion of rat glomerular epithelial cells to extracellular matrices: Role of β1 integrins

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7 January 2021

Integrin-linked kinase as a candidate downstream effector in proteinuria.

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Cyclin-dependent kinase 5 is a regulator of podocyte differentiation, proliferation, and morphology

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Enhanced podocalyxin expression alters the structure of podocyte basal surface

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Podocalyxin activates RhoA and induces actin reorganization through NHERF1 and Ezrin in MDCK cells.

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Progression of glomerular diseases: is the podocyte the culprit?

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Podocytopenia and disease severity in IgA nephropathy

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Glomerular cell number in normal subjects and in type 1 diabetic patients

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Structural alterations to the podocyte are related to proteinuria in type 2 diabetic patients

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

From segmental glomerulosclerosis to total nephron degeneration and interstitial fibrosis: a histopathological study in rat models and human glomerulopathies

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Apical cell membranes are shed into urine from injured podocytes: a novel phenomenon of podocyte injury

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Urinary podocytes in primary focal segmental glomerulosclerosis

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Immunohistochemical and urinary markers of podocyte injury

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Pioglitazone reduces urinary podocyte excretion in type 2 diabetes patients with microalbuminuria

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Urinary excretion of podocytes in patients with diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Urinary podocytes for the assessment of disease activity in lupus nephritis

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Urinary excretion of viable podocytes in health and renal disease

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Podocytes that detach in experimental membranous nephropathy are viable.

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Viable podocytes detach in experimental diabetic nephropathy: potential mechanism underlying glomerulosclerosis

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Altering expression of alpha3beta1 integrin on podocytes of human and rats with diabetes

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Apoptosis in podocytes induced by TGF-beta and Smad7

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Angiotensin II induces apoptosis in rat glomerular epithelial cells

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

The cyclin-dependent kinase inhibitor p21 is required for TGF-beta1-induced podocyte apoptosis

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Hepatocyte growth factor, but not insulin-like growth factor I, protects podocytes against cyclosporin A-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Dexamethasone prevents podocyte apoptosis induced by puromycin aminonucleoside: role of p53 and Bcl-2-related family proteins

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

The cyclin kinase inhibitor p21CIP1/WAF1 limits glomerular epithelial cell proliferation in experimental glomerulonephritis

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Extracellular matrix regulates glomerular epithelial cell survival and proliferation

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Insulin-like growth factors inhibit podocyte apoptosis through the PI3 kinase pathway.

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Basic fibroblast growth factor augments podocyte injury and induces glomerulosclerosis in rats with experimental membranous nephropathy

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Vascular endothelial growth factor and nephrin interact and reduce apoptosis in human podocytes

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Cyclin kinase inhibitors are increased during experimental membranous nephropathy: Potential role in limiting glomerular epithelial cell proliferation in vivo

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Puromycin aminonucleoside induces glomerular epithelial cell apoptosis

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Cell cycle control in glomerular disease

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Mitotic cell cycle proteins increase in podocytes despite lack of proliferation.

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Changes in cell-cycle protein expression during experimental mesangial proliferative glomerulonephritis

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Podocytes Populate Cellular Crescents in a Murine Model of Inflammatory Glomerulonephritis

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Limitation of podocyte proliferation improves renal function in experimental crescentic glomerulonephritis

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Amelioration of nephropathy in mice expressing HIV-1 genes by the cyclin-dependent kinase inhibitor flavopiridol

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

R-roscovitine (CYC202) alleviates renal cell proliferation in nephritis without aggravating podocyte injury

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Differential expression of cyclin-dependent kinase inhibitors in human glomerular disease: role in podocyte proliferation and maturation

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Podocyte expression of the CDK-inhibitor p57 during development and disease

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Complement (C5b-9) induces glomerular epithelial cell DNA synthesis but not proliferation in vitro

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Complement (C5b-9) induces DNA synthesis in rat mesangial cells in vitro

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

DNA damage is a novel response to sublytic complement C5b-9-induced injury in podocytes

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Glomerular basement membrane length to podocyte ratio in human nephronopenia: implications for focal segmental glomerulosclerosis

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Comparison of renal morphology in the Streptozotocin and the SHR/N-cp models of diabetes

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

ACE-inhibition is superior to endothelin A receptor blockade in preventing abnormal capillary supply and fibrosis of the heart in experimental diabetes

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Angiotensin II receptor blocker inhibits p27Kip1 expression in glucose-stimulated podocytes and in diabetic glomeruli

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Podocyte injury promotes progressive nephropathy in zucker diabetic fatty rats

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Mechanical stretch induces podocyte hypertrophy in vitro

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Building the glomerulus: a matricentric view

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

NAD(P)H oxidase activity in cultured human podocytes: effects of adenosine triphosphate

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Induction of antioxidant enzymes in murine podocytes precedes injury by puromycin aminonucleoside

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Glomerular overproduction of oxygen radicals in Mpv17 gene-inactivated mice causes podocyte foot process flattening and proteinuria: A model of steroid-resistant nephrosis sensitive to radical scavenger therapy.

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Proteinuria in passive Heymann nephritis is associated with lipid peroxidation and formation of adducts on type IV collagen

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Protection of alpha(3) integrin-mediated podocyte shape by superoxide dismutase in the puromycin aminonucleoside nephrosis rat.

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Selective modulation of the secretion of proteinases and their inhibitors by growth factors in cultured differentiated podocytes

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Characterization of a glomerular epithelial cell metalloproteinase as matrix metalloproteinase-9 with enhanced expression in a model of membranous nephropathy

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases

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7 January 2021

Angiotensin II stimulates alpha3(IV) collagen production in mouse podocytes via TGF-beta and VEGF signalling: implications for diabetic glomerulopathy

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

ACE inhibitors improve nephrin expression in Zucker rats with glomerulosclerosis

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic rats

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Differential proteomic analysis of proteins induced by glucocorticoids in cultured murine podocytes

1 reference

https://api.crossref.org/works/10.1038/SJ.KI.5000410

7 January 2021

Therapeutic effect of all-trans retinoic acid on rats with anti-GBM antibody glomerulonephritis

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7 January 2021

ATRA induces podocyte differentiation and alters nephrin and podocin expression in vitro and in vivo

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7 January 2021

Identifiers

DOI

10.1038/SJ.KI.5000410

1 reference

release_hyut7ygxhjfshj2dmcusttthyq

14 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/hyut7ygxhjfshj2dmcusttthyq

24 November 2022

mapped directly with Wikidata item

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