Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers (Q36474698)

14 August 2017

Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers (English)

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14 August 2017

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19

Claudio Grassi

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14 August 2017

Domenica D Li Puma

5

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Cristian Ripoli

object named as

Cristian Ripoli

2

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Panchanan Maiti

4

object named as

Panchanan Maiti

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14 August 2017

18

Sally A Frautschy

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14 August 2017

Aida Attar

1

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14 August 2017

Elisa Riccardi

3

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14 August 2017

Tingyu Liu

6

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14 August 2017

Jane Hayes

7

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14 August 2017

Mychica R Jones

8

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14 August 2017

Kristin Lichti-Kaiser

9

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14 August 2017

Fusheng Yang

10

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14 August 2017

Greg D Gale

11

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14 August 2017

Chi-Hong Tseng

12

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14 August 2017

Miao Tan

13

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14 August 2017

Cui-Wei Xie

14

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14 August 2017

Jeffrey L Straudinger

15

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14 August 2017

Frank-Gerrit Klärner

16

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14 August 2017

Thomas Schrader

17

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14 August 2017

Gal Bitan

20

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14 August 2017

language of work or name

English

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publication date

26 November 2012

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14 August 2017

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14 August 2017

135

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14 August 2017

Pt 12

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14 August 2017

3735-3748

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describes a project that uses

14 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3525056/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01

1 reference

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A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

30 September 2017

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Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms

30 September 2017

1 reference

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A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction

30 September 2017

1 reference

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Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

30 September 2017

1 reference

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The acetylation of tau inhibits its function and promotes pathological tau aggregation

30 September 2017

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Peroxynitrite-induced nitrative and oxidative modifications alter tau filament formation.

30 September 2017

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Anti-tau oligomers passive vaccination for the treatment of Alzheimer disease

30 September 2017

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Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity

30 September 2017

1 reference

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Reversal of long-term dendritic spine alterations in Alzheimer disease models

30 September 2017

1 reference

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Synaptic degeneration in Alzheimer's disease

30 September 2017

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The role of tau in neurodegeneration

30 September 2017

1 reference

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Photo-induced cross-linking of unmodified proteins (PICUP) applied to amyloidogenic peptides.

30 September 2017

1 reference

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Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

30 September 2017

1 reference

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The effect of a DeltaK280 mutation on the unfolded state of a microtubule-binding repeat in Tau

30 September 2017

1 reference

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

A genome-wide panel of congenic mice reveals widespread epistasis of behavior quantitative trait loci

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Cell signaling and nuclear receptors: new opportunities for molecular pharmaceuticals in liver disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Cytochrome p450 and chemical toxicology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Pregnane X receptor and natural products: beyond drug-drug interactions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Microvascular injury and blood-brain barrier leakage in Alzheimer's disease

30 September 2017

1 reference

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The human intestinal cytochrome P450 "pie".

30 September 2017

1 reference

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The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Cultured cell and transgenic mouse models for tau pathology linked to beta-amyloid

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

30 September 2017

1 reference

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Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Inflammation and Alzheimer's disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

A synaptic model of memory: long-term potentiation in the hippocampus

30 September 2017

1 reference

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Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Effects of different amyloid β-protein analogues on synaptic function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

A key role for lysine residues in amyloid β-protein folding, assembly, and toxicity.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

On the nucleation of amyloid beta-protein monomer folding

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Effects of chronic SCH23390 treatment on the biochemical and behavioral properties of D1 and D2 dopamine receptors: potentiated behavioral responses to a D2 dopamine agonist after selective D1 dopamine receptor upregulation.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Production of superoxide anions by a CNS macrophage, the microglia

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

2011 Alzheimer's disease facts and figures

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Surprising toxicity and assembly behaviour of amyloid β-protein oxidized to sulfone.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Molecular clip and tweezer introduce new mechanisms of enzyme inhibition

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

21 September 2018

Escaping amyloid fate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Amyloid beta-peptide Abeta(1-42) but not Abeta(1-40) attenuates synaptic AMPA receptor function

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Blood-brain barrier permeability correlates with medial temporal lobe atrophy but not with amyloid-beta protein transport across the blood-brain barrier in Alzheimer's disease.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

A molecular tweezer for lysine and arginine

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Synaptic vesicle transport and synaptic membrane transporter sites in excitatory amino acid nerve terminals in Alzheimer disease

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Scavenging of Alzheimer's amyloid beta-protein by microglia in culture.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

Habituation of exploratory activity in mice: a screening test for memory enhancing drugs

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525056

21 September 2018

Identifiers

DOI

10.1093/BRAIN/AWS289

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

23183235

1 reference