The tick salivary protein sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine IL-9 and is effective in the prevention of experimental asthma. (Q36470838)

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English	The tick salivary protein sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine IL-9 and is effective in the prevention of experimental asthma.	scientific article

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22 January 2020

The tick salivary protein sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine IL-9 and is effective in the prevention of experimental asthma (English)

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22 January 2020

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Sebastian Reuter

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22 January 2020

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22 January 2020

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Helena Horka

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22 January 2020

Valérie Staudt

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22 January 2020

Matthias Klein

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22 January 2020

Christian Taube

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22 January 2020

Nina Dehzad

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22 January 2020

John F Andersen

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22 January 2020

Jan Kopecky

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22 January 2020

Hansjörg Schild

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22 January 2020

Michalis Kotsyfakis

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22 January 2020

Markus Hoffmann

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22 January 2020

Bastian Gerlitzki

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22 January 2020

Michael Stassen

13

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22 January 2020

Edgar Schmitt

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22 January 2020

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10 February 2012

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22 January 2020

Journal of Immunology

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22 January 2020

188

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22 January 2020

6

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22 January 2020

2669-2676

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22 January 2020

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

The immunomodulatory action of sialostatin L on dendritic cells reveals its potential to interfere with autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

The role of saliva in tick feeding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

IL-4 inhibits TGF-beta-induced Foxp3 T cells and, together with TGF-beta, generates IL-9 IL-10 Foxp3(-) effector T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

Ticks produce highly selective chemokine binding proteins with antiinflammatory activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

Suppression of cell proliferation and cytokine expression by HL-p36, a tick salivary gland-derived protein of Haemaphysalis longicornis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

Cystatin protease inhibitors and immune functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

Antiinflammatory and immunosuppressive activity of sialostatin L, a salivary cystatin from the tick Ixodes scapularis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

The Lyme disease agent exploits a tick protein to infect the mammalian host

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

Tick immunobiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

Characterization of a novel salivary immunosuppressive protein from Ixodes ricinus ticks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

Th2 cytokines and asthma. Interleukin-9 as a therapeutic target for asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

Role of IL-9 in the pathophysiology of allergic diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

Identification of an IL-2 binding protein in the saliva of the Lyme disease vector tick, Ixodes scapularis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

Interleukin 9 promotes influx and local maturation of eosinophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

Purification, cloning, and expression of a novel salivary anticomplement protein from the tick, Ixodes scapularis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

Interleukin 9: A candidate gene for asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

30 September 2017

Induction by antigen of intrathymic apoptosis of CD4 CD8 TCRlo thymocytes in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

28 June 2018

IL-1 serves as a secondary signal for IL-9 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

28 June 2018

Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

21 September 2018

Two first-in-human, open-label, phase I dose-escalation safety trials of MEDI-528, a monoclonal antibody against interleukin-9, in healthy adult volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

21 September 2018

IL-9 promotes IL-13-dependent paneth cell hyperplasia and up-regulation of innate immunity mediators in intestinal mucosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

21 September 2018

Inhibition of cAMP degradation improves regulatory T cell-mediated suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

21 September 2018

Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

21 September 2018

A helminth immunomodulator reduces allergic and inflammatory responses by induction of IL-10-producing macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

21 September 2018

Mast cell-derived tumour necrosis factor is essential for allergic airway disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

21 September 2018

Prostaglandin E2 is a major inhibitor of dendritic cell maturation and function in Ixodes scapularis saliva

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

21 September 2018

Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

21 September 2018

Effect of anti-mIL-9 antibody on the development of pulmonary inflammation and airway hyperresponsiveness in allergic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

21 September 2018

IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

4 December 2018

Interleukin-9 potentiates the interleukin-4-induced immunoglobulin (IgG, IgM and IgE) production by normal human B lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523721

4 December 2018

Increased expression of interleukin-9 messenger RNA after segmental allergen challenge in allergic asthmatics

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of alveolar macrophage-derived IL-1 beta in asthma. Inhibition with corticosteroids

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-9 production of naive CD4 T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-13 Mediates In Vivo IL-9 Activities on Lung Epithelial Cells but Not on Hematopoietic Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MEDI-528, an anti-IL-9 humanized antibody for the treatment of asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGF-β interactions with IL-1 family members trigger IL-4-independent IL-9 production by mouse CD4( ) T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum IL-9 levels depend on allergen exposure: preliminary study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4049/JIMMUNOL.1100529

1 reference

Europe PubMed Central

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22 January 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22327077 AND SRC:MED&resulttype=core&format=json

22 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22327077 AND SRC:MED&resulttype=core&format=json

22 January 2020

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