Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. (Q36455995)

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27 January 2020

title

Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1 (English)

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27 January 2020

main subject

protein ubiquitination

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6

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author name string

Juan Wu

1

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Xian Zhang

2

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Ling Zhang

3

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27 January 2020

Ching-Yuan Wu

4

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27 January 2020

Abdol Hossein Rezaeian

5

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Ju-Mei Li

7

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27 January 2020

Jing Wang

8

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Yuan Gao

9

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Fei Han

10

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Yun Seong Jeong

11

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27 January 2020

Xiandao Yuan

12

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Kum Kum Khanna

13

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Jianping Jin

14

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Yi-Xin Zeng

15

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Hui-Kuan Lin

16

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27 January 2020

publication date

29 March 2012

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27 January 2020

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volume

46

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issue

3

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page(s)

351-361

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Regulation of Skp2 expression and activity and its role in cancer progression

27 January 2020

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1 reference

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30 September 2017

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Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

30 September 2017

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Genomic instability--an evolving hallmark of cancer

30 September 2017

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Regulation of Akt signaling activation by ubiquitination

30 September 2017

1 reference

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The E3 ligase TRAF6 regulates Akt ubiquitination and activation

30 September 2017

1 reference

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BRIT1/MCPH1 links chromatin remodelling to DNA damage response.

30 September 2017

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Targeting the ubiquitin system in cancer therapy

30 September 2017

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Ubiquitylation in innate and adaptive immunity.

30 September 2017

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Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

30 September 2017

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Nonproteolytic functions of ubiquitin in cell signaling

30 September 2017

1 reference

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Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

30 September 2017

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Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

30 September 2017

1 reference

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Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

30 September 2017

1 reference

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ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518281

Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518281

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518281

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518281

Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518281

ATM activation and DNA damage response

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518281

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518281

Regulation of the cell cycle by SCF-type ubiquitin ligases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518281

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518281

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518281

Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518281

Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518281

Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis

30 September 2017

1 reference

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Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks

30 September 2017

1 reference

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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518281

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518281

Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

30 September 2017

1 reference

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SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

30 September 2017

1 reference

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Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518281

The many substrates and functions of ATM

30 September 2017

1 reference

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Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

30 September 2017

1 reference

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518281

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

30 September 2017

1 reference

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High expression of S-phase kinase-associated protein 2 (Skp2) is a strong prognostic marker in oral squamous cell carcinoma patients treated by UFT in combination with radiation.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518281

10.1016/J.MOLCEL.2012.02.018

21 September 2018

Identifiers

DOI

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27 January 2020

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27 January 2020

PubMed publication ID

22464731

1 reference

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