Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma (Q36436089)

14 August 2017

Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma (English)

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14 August 2017

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Anurag Purushothaman

1

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14 August 2017

Stephen K Babitz

series ordinal

2

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14 August 2017

Ralph D Sanderson

series ordinal

3

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14 August 2017

language of work or name

English

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publication date

9 October 2012

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Journal of Biological Chemistry

14 August 2017

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14 August 2017

287

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14 August 2017

49

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14 August 2017

41288-41296

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describes a project that uses

14 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3510827/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Heparanase Levels Are Elevated in the Urine and Plasma of Type 2 Diabetes Patients and Associate with Blood Glucose Levels

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SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis

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Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma

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Heparanase influences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myeloma

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Heparanase induces endothelial cell migration via protein kinase B/Akt activation

30 September 2017

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30 September 2017

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30 September 2017

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Overexpression of human insulin receptor substrate 1 induces cellular transformation with activation of mitogen-activated protein kinases

30 September 2017

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Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction

30 September 2017

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30 September 2017

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The IRS-1 signaling system

30 September 2017

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Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling.

30 September 2017

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Staurosporine, a potent inhibitor of phospholipid/Ca dependent protein kinase

28 June 2018

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Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway

28 June 2018

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Biological effects of human insulin receptor substrate-1 overexpression in hepatocytes

21 September 2018

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Insulin receptor substrate-1 regulates the transformed phenotype of BT-20 human mammary cancer cells

21 September 2018

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12 December 2020

Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis

1 reference

12 December 2020

Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma

1 reference

12 December 2020

Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: therapeutic implications

1 reference

12 December 2020

High heparanase activity in multiple myeloma is associated with elevated microvessel density

1 reference

12 December 2020

Heparanase promotes the spontaneous metastasis of myeloma cells to bone

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M112.391417

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

23048032

1 reference