Targeting the ubiquitin-proteasome pathway in breast cancer therapy (Q36429691)

14 August 2017

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title

Targeting the ubiquitin-proteasome pathway in breast cancer therapy (English)

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ubiquitin-proteasome system

14 August 2017

main subject

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2

Robert Z Orlowski

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14 August 2017

1

E Claire Dees

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14 August 2017

language of work or name

English

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publication date

1 February 2006

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14 August 2017

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14 August 2017

volume

2

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14 August 2017

issue

1

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14 August 2017

page(s)

121-135

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The proteasome, a novel protease regulated by multiple mechanisms

14 August 2017

cites work

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Dis-assembly lines: the proteasome and related ATPase-assisted proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Ubiquitin-mediated proteolysis: biological regulation via destruction

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Catalytic activities of the 20 S proteasome, a multicatalytic proteinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Roles of ubiquitin-mediated proteolysis in cell cycle control

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Antigen processing by the proteasome

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Growth factor regulation of a 26S proteasomal subunit in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Biologic and therapeutic role of HER2 in cancer

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

HER-2/neu-mediated regulation of components of the MHC class I antigen-processing pathway.

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Down regulation of major histocompatibility complex class I expression in mammary carcinoma of HER-2/neu transgenic mice.

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Trastuzumab regimens for HER2-overexpressing metastatic breast cancer

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Estrogen and antiestrogen regulation of cell cycle progression in breast cancer cells

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Regulation of the cell cycle by SCF-type ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

HSP90 as a new therapeutic target for cancer therapy: the story unfolds

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Hsp90 inhibitors as novel cancer chemotherapeutic agents

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

A phase 2 study of bortezomib in relapsed, refractory myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Bortezomib or high-dose dexamethasone for relapsed multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

The role of the ubiquitination-proteasome pathway in breast cancer: applying drugs that affect the ubiquitin-proteasome pathway to the therapy of breast cancer

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

NF-kappaB as a therapeutic target in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Evidence that inhibition of p44/42 mitogen-activated protein kinase signaling is a factor in proteasome inhibitor-mediated apoptosis

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

The Ras-Raf-MEK-ERK pathway in the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Proteasome inhibitors can alter the signaling pathways and attenuate the P-glycoprotein-mediated multidrug resistance

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Evidence that mitogen-activated protein kinase phosphatase-1 induction by proteasome inhibitors plays an antiapoptotic role

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

21 January 2018

Cancer statistics, 2005

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https://api.crossref.org/works/10.2217/14796694.2.1.121

COX-2: a molecular target for colorectal cancer prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Preclinical and clinical development of the proteasome inhibitor bortezomib in cancer treatment

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Aromatase inhibitors and bone loss: risks in perspective

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Targeting the ubiquitin-proteasome pathway in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Alpha6beta1 integrin induces proteasome-mediated cleavage of erbB2 in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

alphaB-crystallin as a marker of lymph node involvement in breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Nuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Decreased expression of e6-associated protein in breast and prostate carcinomas

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Estrogen-responsive RING finger protein controls breast cancer growth

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Estrogen receptor-alpha regulates the degradation of insulin receptor substrates 1 and 2 in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Extracellular signal-regulated kinase 7, a regulator of hormone-dependent estrogen receptor destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Gamma synuclein, a novel heat-shock protein-associated chaperone, stimulates ligand-dependent estrogen receptor alpha signaling and mammary tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Effects of ErbB-2 overexpression on mitogenic signalling and cell cycle progression in human breast luminal epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

The p53-MDM2 interaction in a cancer-prone family, and the identification of a novel therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.2217/14796694.2.1.121

Lack of PTEN sequesters CHK1 and initiates genetic instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Post-translationally modified S12, absent in transformed breast epithelial cells, is not associated with the 26S proteasome and is induced by proteasome inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1)

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

SHP‐1 suppresses cancer cell growth by promoting degradation of JAK kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Increased proteasome-dependent degradation of estrogen receptor-alpha by TGF-beta1 in breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Apigenin Induces Apoptosis through Proteasomal Degradation of HER2/neu in HER2/neu-overexpressing Breast Cancer Cells via the Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Retinoic acid-mediated growth arrest requires ubiquitylation and degradation of the F-box protein Skp2.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Estrogen receptor-dependent proteasomal degradation of the glucocorticoid receptor is coupled to an increase in mdm2 protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Implication of proteasome in estrogen receptor degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Distinct effects of the antiestrogen Faslodex on the stability of estrogen receptors-alpha and -beta in the breast cancer cell line MCF-7.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Gefitinib ('Iressa', ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, up-regulates p27KIP1 and induces G1 arrest in oral squamous cell carcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Estrogen receptor alpha and beta subtype expression and transactivation capacity are differentially affected by receptor-, hsp90- and immunophilin-ligands in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Retinoic acid stabilizes p27Kip1 in EBV-immortalized lymphoblastoid B cell lines through enhanced proteasome-dependent degradation of the p45Skp2 and Cks1 proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor alpha-dependent mechanism: relevance in cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

Dysregulation of cellular signaling by HER2 in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

The proteasome-dependent proteolytic system

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796694.2.1.121

21 January 2018

Identifiers

DOI

10.2217/14796694.2.1.121

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14 August 2017

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