Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways (Q36421523)

14 August 2017

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title

Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways (English)

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14 August 2017

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David A Brenner

2

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author name string

Robert F Schwabe

series ordinal

1

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14 August 2017

publication date

1 April 2006

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American Journal of Physiology - Gastrointestinal and Liver Physiology

14 August 2017

published in

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volume

290

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issue

4

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page(s)

G583-9

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Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription

14 August 2017

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Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy

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The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

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Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat.

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IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation

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Missing pieces in the NF-kappaB puzzle

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Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity

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Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

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Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

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Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury

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Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

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To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosis

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NF-kappaB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun

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c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis

21 January 2018

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IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

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NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

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c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration

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Multiple signaling pathways mediate LIF-induced skeletal muscle satellite cell proliferation

21 January 2018

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

21 January 2018

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Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death

21 January 2018

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Nuclear factor {kappa}B inactivation in the rat liver ameliorates short term total warm ischaemia/reperfusion injury

21 January 2018

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Inhibition of JNK activation through NF-kappaB target genes

21 January 2018

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MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines

21 January 2018

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JNK mediates hepatic ischemia reperfusion injury

21 January 2018

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c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation

21 January 2018

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Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

21 January 2018

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Tumor necrosis factor signaling.

21 January 2018

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Cell survival and a Gadd45-factor deficiency

21 January 2018

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21 January 2018

Identifiers

DOI

10.1152/AJPGI.00422.2005

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14 August 2017

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