BCL2 family of apoptosis-related genes: functions and clinical implications in cancer (Q36419013)

14 August 2017

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title

BCL2 family of apoptosis-related genes: functions and clinical implications in cancer (English)

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14 August 2017

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Andreas Scorilas

2

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author name string

Hellinida Thomadaki

series ordinal

1

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14 August 2017

language of work or name

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1 January 2006

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Critical Reviews in Clinical Laboratory Sciences

14 August 2017

published in

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14 August 2017

volume

43

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14 August 2017

issue

1

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14 August 2017

page(s)

1-67

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

14 August 2017

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Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 January 2018

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Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

21 January 2018

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Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

21 January 2018

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Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma

21 January 2018

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Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

21 January 2018

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Differential effects of Bcl-2 on T and B cells in transgenic mice

21 January 2018

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Purification and characterization of the bcl-2 protein

21 January 2018

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Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax.

21 January 2018

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The role of Bcl-2 family members in tumorigenesis

21 January 2018

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Bcl-2 maintains B cell memory

21 January 2018

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Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease

21 January 2018

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Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development

21 January 2018

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GL7 defines the cycling stage of pre-B cells in murine bone marrow.

21 January 2018

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Bcl-2 gene family and related proteins in mammary gland involution and breast cancer

21 January 2018

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https://api.crossref.org/works/10.1080/10408360500295626

Role of BCL-2 in the survival and function of developing and mature sympathetic neurons

21 January 2018

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The Earliest T Lineage–Committed Cells Depend on IL-7 for Bcl-2 Expression and Normal Cell Cycle Progression

21 January 2018

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Bcl‐2 protein inhibits oxysterol‐induced apoptosis through suppressing CPP32‐mediated pathway

21 January 2018

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Inactivation of Bcl-2 by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1080/10408360500295626

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

21 January 2018

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https://api.crossref.org/works/10.1080/10408360500295626

Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

21 January 2018

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https://api.crossref.org/works/10.1080/10408360500295626

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

21 January 2018

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https://api.crossref.org/works/10.1080/10408360500295626

Bcl-2 regulates amplification of caspase activation by cytochrome c.

21 January 2018

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https://api.crossref.org/works/10.1080/10408360500295626

Inhibition of Bax channel-forming activity by Bcl-2

21 January 2018

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https://api.crossref.org/works/10.1080/10408360500295626

Channel formation by antiapoptotic protein Bcl-2.

21 January 2018

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https://api.crossref.org/works/10.1080/10408360500295626

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The Bcl2 family: regulators of the cellular life-or-death switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release

21 January 2018

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https://api.crossref.org/works/10.1080/10408360500295626

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

A Novel Bcl-x Isoform Connected to the T Cell Receptor Regulates Apoptosis in T Cells

21 January 2018

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https://api.crossref.org/works/10.1080/10408360500295626

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

21 January 2018

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https://api.crossref.org/works/10.1080/10408360500295626

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1080/10408360500295626

Solution structure of BID, an intracellular amplifier of apoptotic signaling

21 January 2018

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https://api.crossref.org/works/10.1080/10408360500295626

Bcl-x(L) forms an ion channel in synthetic lipid membranes.

21 January 2018

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https://api.crossref.org/works/10.1080/10408360500295626

Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death

21 January 2018

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https://api.crossref.org/works/10.1080/10408360500295626

Boo, a novel negative regulator of cell death, interacts with Apaf-1.

21 January 2018

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https://api.crossref.org/works/10.1080/10408360500295626

Elevated expression of Bcl-2 and Bcl-x by intestinal intraepithelial lymphocytes: resistance to apoptosis by glucocorticoids and irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Functional analysis of the human MCL-1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Expression of the antiapoptotic MCL1 gene product is regulated by a mitogen activated protein kinase-mediated pathway triggered through microtubule disruption and protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Cooperative regulation of Mcl-1 by Janus kinase/stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bcl-2 phosphorylation required for anti-apoptosis function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Myeloid cell leukemia 1 is phosphorylated through two distinct pathways, one associated with extracellular signal-regulated kinase activation and the other with G2/M accumulation or protein phosphatase 1/2A inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Selective inhibition of apoptosis by TPA-induced differentiation of U937 leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Mcl-1 and Bcl-xL are co-regulated by IL-6 in human myeloma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Differential expression of bcl-w and bcl-x messenger RNA in the developing and adult rat nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Testicular degeneration in Bclw-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Tissue expression and subcellular localization of the pro-survival molecule Bcl-w

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bcl-w(edding) with mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bcl-w forms complexes with Bax and Bak, and elevated ratios of Bax/Bcl-w and Bak/Bcl-w correspond to spermatogonial and spermatocyte apoptosis in the testis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Improvement of the viability of cultured rat neurons by the non-essential amino acids L-serine and glycine that upregulates expression of the anti-apoptotic gene product Bcl-w

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Characterization of NR13-related human cell death regulator, Boo/Diva, in normal and cancer tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

GRS, a novel member of the Bcl-2 gene family, is highly expressed in multiple cancer cell lines and in normal leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Functional dissection of Bfl-1, a Bcl-2 homolog: anti-apoptosis, oncogene-cooperation and cell proliferation activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Multiple gene duplication and expression of mouse bcl-2-related genes, A1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bfl-1S, a novel alternative splice variant of Bfl-1, localizes in the nucleus via its C-terminus and prevents cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

In vitro Brucella suis infection prevents the programmed cell death of human monocytic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Mapping of the human BAX gene to chromosome 19q13.3–q13.4 and isolation of a novel alternatively spliced transcript, BAXδ

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The distal pathway of lipoprotein-induced cholesterol esterification, but not sphingomyelinase-induced cholesterol esterification, is energy-dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Conformation of the Bax C-terminus regulates subcellular location and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Structure of Bax: coregulation of dimer formation and intracellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bid, but not Bax, regulates VDAC channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Breaking the mitochondrial barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Apoptosis: mitochondrial membrane permeabilization--the (w)hole story?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2 ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Regulated targeting of BAX to mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Purification and biochemical properties of soluble recombinant human Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Relative level of expression of Bax and Bcl-XL determines the cellular fate of apoptosis/necrosis induced by the overexpression of Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Gene Structure, cDNA Sequence, and Expression of Murine Bak, a Proapoptotic Bcl-2 Family Member

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons, but pro-apoptotic in non-neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

A splicing variant of the Bcl-2 member Bok with a truncated BH3 domain induces apoptosis but does not dimerize with antiapoptotic Bcl-2 proteins in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Resistance of MCF7 human breast carcinoma cells to TNF-induced cell death is associated with loss of p53 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

BOK and NOXA are essential mediators of p53-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Role of Mtd/Bok in normal and neoplastic B-cell development in the bursa of Fabricius

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Expression and Function of a Proapoptotic Bcl-2 Family Member Bcl-XL/Bcl-2-Associated Death Promoter (BAD) in Rat Ovary*

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Rac1 inhibits apoptosis in human lymphoma cells by stimulating Bad phosphorylation on Ser-75.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Cleavage of 14-3-3 protein by caspase-3 facilitates bad interaction with Bcl-x(L) during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Phenylephrine promotes phosphorylation of Bad in cardiac myocytes through the extracellular signal-regulated kinases 1/2 and protein kinase A

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

BAD is a pro-survival factor prior to activation of its pro-apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

BID: a novel BH3 domain-only death agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Ion channel activity of the BH3 only Bcl-2 family member, BID.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The mitochondrial death/life regulator in apoptosis and necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Three novel Bid proteins generated by alternative splicing of the human Bid gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Human HRK gene maps to position 12q13.1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Molecular Cloning of a Novel Polypeptide, DP5, Induced during Programmed Neuronal Death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Up-regulation of Hrk, a regulator of cell death, in retinal ganglion cells of axotomized rat retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Expression of apoptosis-related genes during human preimplantation embryo development: potential roles for the Harakiri gene product and Caspase-3 in blastomere fragmentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Interleukin 3-dependent activation of DREAM is involved in transcriptional silencing of the apoptotic Hrk gene in hematopoietic progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bim: a novel member of the Bcl-2 family that promotes apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Molecular mechanisms of activated T cell death in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Extracellular Regulated Kinase, but Not Protein Kinase C, Is an Antiapoptotic Signal of Insulin-like Growth Factor-1 on Cultured Cardiac Myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Regulation of expression of Bcl-2 protein family member Bim by T cell receptor triggering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The C. elegans orthologue ceBNIP3 interacts with CED-9 and CED-3 but kills through a BH3- and caspase-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Novel BNIP1 variants and their interaction with BCL2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Functional identification of the apoptosis effector BH3 domain in cellular protein BNIP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Nip21 gene expression reduces coxsackievirus B3 replication by promoting apoptotic cell death via a mitochondria-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Cloning of BNIP3h, a member of proapoptotic BNIP3 family genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The E1B 19K/Bcl-2–binding Protein Nip3 is a Dimeric Mitochondrial Protein that Activates Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Structural analysis of the human pro-apoptotic gene Bik: chromosomal localization, genomic organization and localization of promoter sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Functional dissection of the pro-apoptotic protein Bik. Heterodimerization with anti-apoptosis proteins is insufficient for induction of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Phosphorylation of the pro-apoptotic protein BIK: mapping of phosphorylation sites and effect on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Activation of multidomain and BH3-only pro-apoptotic Bcl-2 family members in p53-defective cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The Molecular Mechanism of Noxa-induced Mitochondrial Dysfunction in p53-Mediated Cell Death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Genomic alterations in nasopharyngeal carcinoma: loss of heterozygosity and Epstein-Barr virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

PUMA in head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22-23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery-Dreifuss muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bcl-rambo beta, a special splicing variant with an insertion of an Alu-like cassette, promotes etoposide- and Taxol-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bcl-G, a novel pro-apoptotic member of the Bcl-2 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

A detailed transcriptional map of the chromosome 12p12 tumour suppressor locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Characterization of ubiquitin‐like polypeptide acceptor protein, a novel pro‐apoptotic member of the Bcl2 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Nrh, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Characterization of the anti-apoptotic mechanism of Bcl-B

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bc1-2, Raf-1 and mitochondrial regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Developmental expression of Bcl-2 protein in human cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bcl-X(L) inhibits apoptosis and necrosis produced by Alzheimer's beta-amyloid1-40 peptide in PC12 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Expression of apoptosis related proteins in brains of patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Dopaminergic neurons degenerate by apoptosis in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

21 January 2018

How does HIV cause AIDS?

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

High levels of HIV-1 replication show a clear correlation with downmodulation of Bcl-2 protein in peripheral blood lymphocytes of HIV-1-seropositive subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The polymorphic 43Thr bcl-2 protein confers relative resistance to autoimmunity: an analytical evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

A unique pathway of cardiac myocyte death caused by hypoxia-acidosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Resistance of T-cells to apoptosis in autoimmune diabetic (NOD) mice is increased early in life and is associated with dysregulated expression of Bcl-x

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Loss of heterozygosity at the bcl-2 gene locus and expression of bcl-2 in human gastric and colorectal carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

BCL-2 immunohistochemical evaluation in B-cell chronic lymphocytic leukemia and hairy cell leukemia before treatment with fludarabine and 2-chloro-deoxy-adenosine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Role of Bcl-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Calphostin C synergistically induces apoptosis with VP-16 in lymphoma cells which express abundant phosphorylated Bcl-2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Effects of Bcl-2 modulation with G3139 antisense oligonucleotide on human breast cancer cells are independent of inherent Bcl-2 protein expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Oblimersen Bcl-2 antisense: facilitating apoptosis in anticancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The future of antisense therapy: combination with anticancer treatments

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Apoptosis and expression of Bcl-2, Bcl-XL, and Bax in renal cell carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

c-Myb and Bcl-x overexpression predicts poor prognosis in colorectal cancer: clinical and experimental findings

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Heterodimerization of Bcl-2 and Bcl-X(L) with Bax and Bad in colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bad-deficient mice develop diffuse large B cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Proapoptotic BID is required for myeloid homeostasis and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Necrotic Cell Death in Response to Oxidant Stress Involves the Activation of the Apoptogenic Caspase-8/Bid Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Impaired BAX protein expression in breast cancer: mutational analysis of the BAX and the p53 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Abnormal intracellular localization of Bax with a normal membrane anchor domain in human lung cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Protein kinase Cepsilon interacts with Bax and promotes survival of human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Adenovirus-mediated transfer of bax with caspase-8 controlled by myelin basic protein promoter exerts an enhanced cytotoxic effect in gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Pro-apoptotic treatment with an adenovirus encoding Bax enhances the effect of chemotherapy in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Reduced expression of Bax in ceramide-resistant HL-60 subline

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

BAK overexpression mediates p53-independent apoptosis inducing effects on human gastric cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Genomic structure and domain organisation of the human Bak gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Genetic alterations in the coding region of the bak gene in uterine cervical carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

IFNgamma sensitization to TRAIL-induced apoptosis in human thyroid carcinoma cells by upregulating Bak expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Nonredundant role of Bax and Bak in Bid-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bcl-w expression in colorectal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Mutational analysis of Noxa gene in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Noxa in colorectal cancer: a study on DNA, mRNA and protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bim is a suppressor of Myc-induced mouse B cell leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Lovastatin-induced up-regulation of the BH3-only protein, Bim, and cell death in glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Alteration in copy numbers of genes as a mechanism for acquired drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Up-regulation of Bfl-1/A1 via NF-kappaB activation in cisplatin-resistant human bladder cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The Bcl-2 family member Bfl-1/A1 is strongly repressed in normal and malignant plasma cells but is a potent anti-apoptotic factor for myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bcl-2 family gene modulation during spontaneous apoptosis of B-chronic lymphocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The bfl-1 gene is transcriptionally upregulated by the Epstein-Barr virus LMP1, and its expression promotes the survival of a Burkitt's lymphoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bfl-1 Gene Expression in Breast Cancer: Its Relationship with other Prognostic Factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Cisplatin-induced apoptosis in HL-60 human promyelocytic leukemia cells: differential expression of BCL2 and novel apoptosis-related gene BCL2L12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

MCL-1 expression in B-cell non-Hodgkin's lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Increased MCL-1 expression is associated with poor prognosis in ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Mcl-1 expression in gestational trophoblastic disease correlates with clinical outcome: a differential expression study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

C-Raf-1 protein kinase is not essential for Ras transformation of mouse embryo fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Determination of c-myc amplification and overexpression in breast cancer patients: evaluation of its prognostic value against c-erbB-2, cathepsin-D and clinicopathological characteristics using univariate and multivariate analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

The Cell Death Regulatory Protein Bak Is Expressed in Endothelial Cells in Inflamed Tissues and Is Induced by IFN-γ in Vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Upregulation of the pro-apoptotic BH3-only peptide harakiri in spinal neurons of amyotrophic lateral sclerosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Role of PI3-kinase in Bcl-X induction and apoptosis inhibition mediated by IL-3 or IGF-1 in Baf-3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

Bik and Bak Induce Apoptosis Downstream of CrmA but Upstream of Inhibitor of Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408360500295626

10.1080/10408360500295626

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference