Terminal myeloid differentiation in vivo is induced by FLT3 inhibition in FLT3/ITD AML. (Q36410157)

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9 March 2020

title

Terminal myeloid differentiation in vivo is induced by FLT3 inhibition in FLT3/ITD AML (English)

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7

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author name string

Amy Sexauer

1

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Alexander Perl

2

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Xiaochuan Yang

3

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Michael Borowitz

4

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Christopher Gocke

5

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Trivikram Rajkhowa

6

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Mark Frattini

8

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Grant E Nybakken

9

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Keith Pratz

10

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Judith Karp

11

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B Douglas Smith

12

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Mark Levis

13

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language of work or name

English

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publication date

25 September 2012

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volume

120

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issue

20

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9 March 2020

page(s)

4205-4214

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Phase I study of sorafenib in patients with refractory or relapsed acute leukemias

9 March 2020

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Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics

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Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations.

30 September 2017

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Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

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In vitro studies of a FLT3 inhibitor combined with chemotherapy: sequence of administration is important to achieve synergistic cytotoxic effects

30 September 2017

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CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations

30 September 2017

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Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia

30 September 2017

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Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression

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28 June 2018

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28 June 2018

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Stromal niche cells protect early leukemic FLT3-ITD progenitor cells against first-generation FLT3 tyrosine kinase inhibitors.

28 June 2018

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Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412.

21 September 2018

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21 September 2018

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21 September 2018

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21 September 2018

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A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations

21 September 2018

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21 September 2018

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Identifiers

DOI

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9 March 2020

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9 March 2020

PubMed publication ID

23012328

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