Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling. (Q36408686)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23063522 AND SRC:MED&resulttype=core&format=json

10 March 2020

title

Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling (English)

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10 March 2020

8

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10 March 2020

author name string

Jiangbo Wang

1

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10 March 2020

Robert A Mook

2

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10 March 2020

Jiuyi Lu

3

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10 March 2020

David M Gooden

4

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10 March 2020

Anthony Ribeiro

5

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10 March 2020

Anchen Guo

6

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10 March 2020

Larry S Barak

7

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10 March 2020

Wei Chen

9

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10 March 2020

language of work or name

English

0 references

publication date

23 September 2012

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Bioorganic & Medicinal Chemistry

10 March 2020

published in

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10 March 2020

volume

20

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10 March 2020

issue

22

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10 March 2020

page(s)

6751-6757

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Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

10 March 2020

cites work

1 reference

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The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks.

30 September 2017

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Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model

30 September 2017

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Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists

30 September 2017

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The Hedgehog's tale: developing strategies for targeting cancer

30 September 2017

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Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened.

30 September 2017

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Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.

30 September 2017

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Impact of Prenatal Exposure to Piperonyl Butoxide and Permethrin on 36-Month Neurodevelopment

30 September 2017

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Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

30 September 2017

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Clinical experience with Hedgehog pathway inhibitors

30 September 2017

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Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

30 September 2017

1 reference

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Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine

30 September 2017

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Small-molecule modulators of the Sonic Hedgehog signaling pathway.

30 September 2017

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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

30 September 2017

1 reference

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Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

30 September 2017

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Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy

30 September 2017

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Hedgehog-Gli signaling pathway inhibitors as anticancer agents.

30 September 2017

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Hedgehog signaling in development and cancer.

30 September 2017

1 reference

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Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

30 September 2017

1 reference

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Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells

30 September 2017

1 reference

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Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration

30 September 2017

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Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway

30 September 2017

1 reference

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Brain as a paradigm of organ growth: Hedgehog-Gli signaling in neural stem cells and brain tumors.

30 September 2017

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Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2

30 September 2017

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Tissue repair and stem cell renewal in carcinogenesis

30 September 2017

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Hedgehog signalling in prostate regeneration, neoplasia and metastasis

30 September 2017

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Phthalates, Alkylphenols, Pesticides, Polybrominated Diphenyl Ethers, and Other Endocrine-Disrupting Compounds in Indoor Air and Dust

30 September 2017

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Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

30 September 2017

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Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

30 September 2017

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Hair cycle regulation of Hedgehog signal reception

30 September 2017

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Small molecule modulation of Smoothened activity

30 September 2017

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Mutations in SUFU predispose to medulloblastoma

30 September 2017

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Hedgehog signaling in animal development: paradigms and principles

30 September 2017

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The Hedgehog and Wnt signalling pathways in cancer

30 September 2017

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

30 September 2017

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Regular articles: conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration

30 September 2017

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Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization

30 September 2017

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Sonic hedgehog regulates the growth and patterning of the cerebellum

30 September 2017

1 reference

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Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501270

Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501270

Activating Smoothened mutations in sporadic basal-cell carcinoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501270

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

30 September 2017

1 reference

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Smoothened antagonists for hair inhibition.

30 September 2017

1 reference

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Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

28 June 2018

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Sonic hedgehog controls stem cell behavior in the postnatal and adult brain

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501270

Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched.

28 June 2018

1 reference

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Sporadic medulloblastomas contain PTCH mutations.

28 June 2018

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Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies

28 June 2018

1 reference

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Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.

21 September 2018

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Essential role for Sonic hedgehog during hair follicle morphogenesis

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23063522

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BMC.2012.09.030

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23063522 AND SRC:MED&resulttype=core&format=json

10 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23063522 AND SRC:MED&resulttype=core&format=json

10 March 2020

PubMed publication ID

23063522

1 reference