Homeostatic maintenance of natural Foxp3( ) CD25( ) CD4( ) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization (Q36402763)

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English	Homeostatic maintenance of natural Foxp3( ) CD25( ) CD4( ) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization	scientific article

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9 January 2020

Homeostatic maintenance of natural Foxp3( ) CD25( ) CD4( ) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization (English)

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9 January 2020

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autoimmune disease

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9 January 2020

Shimon Sakaguchi

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Shimon Sakaguchi

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9 January 2020

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Ruka Setoguchi

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9 January 2020

Takeshi Takahashi

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9 January 2020

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1 March 2005

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9 January 2020

Journal of Experimental Medicine

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9 January 2020

201

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9 January 2020

5

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9 January 2020

723-735

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9 January 2020

Interleukin-2 is essential for CD4 CD25 regulatory T cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Naturally arising CD4 regulatory t cells for immunologic self-tolerance and negative control of immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Loss of Tolerance and Autoimmunity Affecting Multiple Organs inSTAT5A/5B-Deficient Mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Continuous activation of autoreactive CD4 CD25 regulatory T cells in the steady state.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

An essential role for Scurfin in CD4 CD25 T regulatory cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Foxp3 programs the development and function of CD4 CD25 regulatory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Control of regulatory T cell development by the transcription factor Foxp3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Interleukin 2 signaling is required for CD4( ) regulatory T cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

CD25 CD4 T cells contribute to the control of memory CD8 T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Stimulation of CD25( )CD4( ) regulatory T cells through GITR breaks immunological self-tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice.

1 reference

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30 September 2017

Inducible IL-2 production by dendritic cells revealed by global gene expression analysis.

1 reference

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30 September 2017

B7/CD28 costimulation is essential for the homeostasis of the CD4 CD25 immunoregulatory T cells that control autoimmune diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Thymus and autoimmunity: production of CD25 CD4 naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

1 reference

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30 September 2017

CD4 CD25 immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Autoreactivity of T cells from nonobese diabetic mice: An I-Ag7-dependent reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Interleukin-2 deficient mice: a new model to study autoimmunity and self-tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Genetic control of autoimmune diabetes in the NOD mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Human T-lymphocyte growth factor: regulation of growth and function of T lymphocytes.

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30 September 2017

Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

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30 September 2017

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Lack of intermediate-affinity interleukin-2 receptor in mice leads to dependence on interleukin-2 receptor alpha, beta and gamma chain expression for T cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

30 September 2017

Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

28 June 2018

Turnover of naive- and memory-phenotype T cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

28 June 2018

Interleukin-2-dependent control of disease development in spontaneously diabetic BB rats

1 reference

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28 June 2018

Recovery from autoimmunity of MRL/lpr mice after infection with an interleukin-2/vaccinia recombinant virus

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28 June 2018

High Incidence of Thyroiditis and Anti-Thyroid Autoantibodies in NOD Mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

28 June 2018

Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3 CD25 CD4 regulatory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

21 September 2018

Cutting edge: IL-2 is critically required for the in vitro activation of CD4 CD25 T cell suppressor function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

21 September 2018

Distinct effects of STAT5 activation on CD4 and CD8 T cell homeostasis: development of CD4 CD25 regulatory T cells versus CD8 memory T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

21 September 2018

Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4 regulatory T cells and IL-10.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

21 September 2018

Peripheral expansion of thymus-derived regulatory cells in anti-myelin basic protein T cell receptor transgenic mice

1 reference

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21 September 2018

The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements

1 reference

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21 September 2018

Type I diabetes and multiple sclerosis patients target islet plus central nervous system autoantigens; nonimmunized nonobese diabetic mice can develop autoimmune encephalitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

21 September 2018

Immunologic self-tolerance maintained by CD25 CD4 naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

21 September 2018

Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

1 reference

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21 September 2018

CD4 CD25high regulatory cells in human peripheral blood

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212841

21 October 2018

DIFFERENTIAL GLYCOSYLATION OF INTERLEUKIN 2, THE MOLECULAR BASIS FOR THE NOD Idd3 TYPE 1 DIABETES GENE?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naturally anergic and suppressive CD25( )CD4( ) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-2 is indispensable for development of immunological self-tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homeostasis of peripheral CD4 T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4 T cell numbers

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential Role for STAT5 Signaling in CD25 CD4 Regulatory T Cell Homeostasis and the Maintenance of Self-Tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac ( ) cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunostimulation circumvents diabetes in NOD/Lt mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sialadenitis in nonobese diabetic mice: transfer into syngeneic healthy neonates by splenic T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD25 CD4 T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of T cell hyperactivation in IL-2-deficient mice by CD4( )CD25(-) and CD4( )CD25( ) T cells: evidence for two distinct regulatory mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homeostasis and anergy of CD4( )CD25( ) suppressor T cells in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.20041982

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15753206 AND SRC:MED&resulttype=core&format=json

9 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15753206 AND SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15753206 AND SRC:MED&resulttype=core&format=json

9 January 2020

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