The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity. (Q36384699)

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9 January 2020

title

The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity (English)

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9 January 2020

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1

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9 January 2020

Hiroyuki Konishi

3

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9 January 2020

William Matsui

8

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author name string

Abde M Abukhdeir

2

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9 January 2020

Joseph P Garay

4

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John P Gustin

5

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Qiuju Wang

6

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9 January 2020

Robert J Arceci

7

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9 January 2020

Ben Ho Park

9

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language of work or name

English

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publication date

17 October 2007

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9 January 2020

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volume

111

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issue

2

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page(s)

856-864

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describes a project that uses

9 January 2020

KMS-11 WHSC1( /-)

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KMS-11 WHSC1(trans/-)

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cites work

A PCR-based high-throughput screen with multiround sample pooling: application to somatic cell gene targeting

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Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation

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P21 gene knock down does not identify genetic effectors seen with gene knock out.

30 September 2017

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Ten years and counting: so what do we know about t(4;14)(p16;q32) multiple myeloma.

30 September 2017

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Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

30 September 2017

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30 September 2017

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Transcription repression activity is associated with the type I isoform of the MMSET gene involved in t(4;14) in multiple myeloma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2200833

Molecular pathogenesis and a consequent classification of multiple myeloma

30 September 2017

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Identification of ID-1 as a potential target gene of MMSET in multiple myeloma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2200833

Fibroblast growth factor receptor 3 inhibition by short hairpin RNAs leads to apoptosis in multiple myeloma.

30 September 2017

1 reference

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Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2200833

Advances in biology of multiple myeloma: clinical applications

30 September 2017

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Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma

30 September 2017

1 reference

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Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

30 September 2017

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Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses

30 September 2017

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Activation of the interferon system by short-interfering RNAs

30 September 2017

1 reference

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Critical roles for immunoglobulin translocations and cyclin D dysregulation in multiple myeloma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2200833

A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2200833

A unique mRNA initiated within a middle intron of WHSC1/MMSET encodes a DNA binding protein that suppresses human IL-5 transcription

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2200833

Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by reverse transcription-polymerase chain reaction analysis of IGH-MMSET fusion transcripts

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2200833

The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2200833

WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2200833

Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma

30 September 2017

1 reference

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Molecular classification of multiple myeloma: a distinct transcriptional profile characterizes patients expressing CCND1 and negative for 14q32 translocations.

30 September 2017

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A global expression-based analysis of the consequences of the t(4;14) translocation in myeloma.

21 September 2018

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Targeted transgene insertion into human chromosomes by adeno-associated virus vectors

21 September 2018

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Induction of an interferon response by RNAi vectors in mammalian cells

21 September 2018

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Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

5 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17942756

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Gene expression profiling of plasma cell dyscrasias reveals molecular patterns associated with distinct IGH translocations in multiple myeloma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17942756

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17942756

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2007-05-088674

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942756 AND SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942756 AND SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

17942756

1 reference