Targeted Deletion of p53 in Lgr5-Expressing Intestinal Stem Cells Promotes Colon Tumorigenesis in a Preclinical Model of Colitis-Associated Cancer (Q36378272)

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English	Targeted Deletion of p53 in Lgr5-Expressing Intestinal Stem Cells Promotes Colon Tumorigenesis in a Preclinical Model of Colitis-Associated Cancer	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

13 August 2017

Targeted Deletion of p53 in Lgr5-Expressing Intestinal Stem Cells Promotes Colon Tumorigenesis in a Preclinical Model of Colitis-Associated Cancer (English)

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Europe PubMed Central

PMC publication ID

13 August 2017

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26631266 AND SRC:MED&resulttype=core&format=json

8 June 2020

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Laurie A Davidson

1

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8 June 2020

Evelyn S Callaway

2

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8 June 2020

Eunjoo Kim

3

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8 June 2020

Yang-Yi Fan

5

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8 June 2020

Clinton D Allred

6

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8 June 2020

Robert S Chapkin

7

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8 June 2020

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2 December 2015

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13 August 2017

Cancer Research

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8 June 2020

75

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8 June 2020

24

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8 June 2020

5392-5397

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8 June 2020

Krt19( )/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine

1 reference

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30 September 2017

Colorectal cancer stem cells: from the crypt to the clinic

1 reference

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30 September 2017

Single-cell analysis of proxy reporter allele-marked epithelial cells establishes intestinal stem cell hierarchy

1 reference

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30 September 2017

Plasticity within stem cell hierarchies in mammalian epithelia

1 reference

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30 September 2017

Refining the role for adult stem cells as cancer cells of origin

1 reference

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30 September 2017

Activation of Cre recombinase alone can induce complete tumor regression

1 reference

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30 September 2017

Caught in the cross fire: p53 in inflammation.

1 reference

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30 September 2017

Stem cell dynamics in homeostasis and cancer of the intestine

1 reference

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30 September 2017

p53: the barrier to cancer stem cell formation.

1 reference

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30 September 2017

Long-lived intestinal tuft cells serve as colon cancer-initiating cells

1 reference

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30 September 2017

Sox9 induction, ectopic Paneth cells, and mitotic spindle axis defects in mouse colon adenomatous epithelium arising from conditional biallelic Apc inactivation

1 reference

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Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing

1 reference

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Attractor landscape analysis reveals feedback loops in the p53 network that control the cellular response to DNA damage

1 reference

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Alteration of colonic stem cell gene signatures during the regenerative response to injury

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Gastrointestinal stem cells in self-renewal and cancer

1 reference

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30 September 2017

Tissue-resident adult stem cell populations of rapidly self-renewing organs

1 reference

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30 September 2017

Puma is required for p53-induced depletion of adult stem cells

1 reference

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30 September 2017

Cancerous stem cells: deviant stem cells with cancer-causing misbehavior

1 reference

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30 September 2017

p53 and stem cells: new developments and new concerns

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681667

30 September 2017

IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681667

30 September 2017

p53 and metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681667

30 September 2017

Crypt stem cells as the cells-of-origin of intestinal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681667

30 September 2017

Comparative lesion sequencing provides insights into tumor evolution

1 reference

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30 September 2017

An oncogene-induced DNA damage model for cancer development

1 reference

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30 September 2017

Identification of stem cells in small intestine and colon by marker gene Lgr5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681667

30 September 2017

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681667

30 September 2017

Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers

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Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice

1 reference

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28 June 2018

Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease

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Early alterations of apoptosis and cell proliferation in azoxymethane-initiated rat colonic epithelium.

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21 September 2018

Defining stem cell dynamics in models of intestinal tumor initiation.

1 reference

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Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors

1 reference

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1 reference

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12 December 2020

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10.1158/0008-5472.CAN-15-1706

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Europe PubMed Central

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8 June 2020

PMC publication ID

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Europe PubMed Central

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8 June 2020

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8 June 2020

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