Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation. (Q36368577)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11085743 AND SRC:MED&resulttype=core&format=json

2 November 2019

title

Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation (English)

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2 November 2019

0 references

4

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2 November 2019

Joseph A. Trapani

8

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2 November 2019

author name string

V R Sutton

1

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2 November 2019

J E Davis

2

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2 November 2019

M Cancilla

3

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2 November 2019

A A Ruefli

5

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2 November 2019

K Sedelies

6

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2 November 2019

K A Browne

7

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2 November 2019

language of work or name

English

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publication date

1 November 2000

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Journal of Experimental Medicine

2 November 2019

published in

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2 November 2019

volume

192

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2 November 2019

issue

10

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2 November 2019

page(s)

1403-1414

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Hsp27 negatively regulates cell death by interacting with cytochrome c.

2 November 2019

cites work

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

30 September 2017

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Apoptotic pathways: paper wraps stone blunts scissors

30 September 2017

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Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

30 September 2017

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Differences between CD95 type I and II cells detected with the CD95 ligand

30 September 2017

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Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

30 September 2017

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Granzyme B-induced loss of mitochondrial inner membrane potential (Delta Psi m) and cytochrome c release are caspase independent

30 September 2017

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Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction

30 September 2017

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BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis

30 September 2017

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Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis

30 September 2017

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

30 September 2017

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Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

30 September 2017

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Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

30 September 2017

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

30 September 2017

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The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

30 September 2017

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Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro.

30 September 2017

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BID: a novel BH3 domain-only death agonist

30 September 2017

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The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32

30 September 2017

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Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

30 September 2017

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In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

30 September 2017

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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

30 September 2017

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Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

30 September 2017

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Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Immunopurification of functional Asp-ase (natural killer cell granzyme B) using a monoclonal antibody

28 June 2018

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The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster

28 June 2018

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A natural killer cell granule protein that induces DNA fragmentation and apoptosis

28 June 2018

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Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing

28 June 2018

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Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

28 June 2018

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Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1

21 January 2018

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Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway

21 January 2018

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Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes

21 January 2018

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New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

21 October 2018

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New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis

21 January 2018

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12 December 2020

Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases

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12 December 2020

Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation

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12 December 2020

Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c rel

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12 December 2020

Identifiers

DOI

10.1084/JEM.192.10.1403

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11085743 AND SRC:MED&resulttype=core&format=json

2 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11085743 AND SRC:MED&resulttype=core&format=json

2 November 2019

PubMed publication ID

11085743

1 reference