Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. (Q36367938)

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English	Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis.	scientific article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9892605 AND SRC:MED&resulttype=core&format=json

8 December 2019

Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9892605 AND SRC:MED&resulttype=core&format=json

8 December 2019

apoptotic process

0 references

1 reference

based on heuristic

inferred from title

autoimmune disease

1 reference

based on heuristic

inferred from title

autoimmune uveitis

1 reference

based on heuristic

inferred from title

Rachel R. Caspi

7

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9892605 AND SRC:MED&resulttype=core&format=json

8 December 2019

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T K Tarrant

1

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8 December 2019

P B Silver

2

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8 December 2019

J L Wahlsten

3

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8 December 2019

L V Rizzo

4

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8 December 2019

C C Chan

5

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8 December 2019

B Wiggert

6

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8 December 2019

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1 January 1999

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8 December 2019

Journal of Experimental Medicine

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8 December 2019

189

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8 December 2019

2

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8 December 2019

219-230

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8 December 2019

Uveitogenicity is associated with a Th1-like lymphokine profile: cytokine-dependent modulation of early and committed effector T cells in experimental autoimmune uveitis

1 reference

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30 September 2017

DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death

1 reference

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30 September 2017

Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis

1 reference

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30 September 2017

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4( ) TH1-like responses

1 reference

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30 September 2017

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

1 reference

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30 September 2017

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1 reference

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30 September 2017

Cytokine-induced apoptotic cell death in a mouse pancreatic beta-cell line: inhibition by Bcl-2.

1 reference

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30 September 2017

Synergistic stimulatory effects of tumour necrosis factor alpha and interferon gamma on replication of human immunodeficiency virus type 1 and on apoptosis of HIV-1-infected host cells

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30 September 2017

Bcl-2 protects macrophages from nitric oxide-induced apoptosis

1 reference

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30 September 2017

Apoptotic death of human leukemic cells induced by vascular cells expressing nitric oxide synthase in response to gamma-interferon and tumor necrosis factor-alpha

1 reference

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30 September 2017

Establishment and characterization of a murine CD4 T cell line and clone that induce experimental autoimmune uveoretinitis in B10.A mice.

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30 September 2017

Multiple defects of immune cell function in mice with disrupted interferon-gamma genes

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30 September 2017

Recombinant interleukin 12 cures mice infected with Leishmania major

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30 September 2017

Development of TH1 CD4 T cells through IL-12 produced by Listeria-induced macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

30 September 2017

Interferon-gamma (IFN-gamma) induces programmed cell death in differentiated human leukemic B cell lines

1 reference

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30 September 2017

Interleukin-2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

30 September 2017

Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

30 September 2017

The role of IL-12 in the induction of organ-specific autoimmune diseases

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

30 September 2017

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

30 September 2017

Identification of an immunodominant and highly immunopathogenic determinant in the retinal interphotoreceptor retinoid-binding protein (IRBP).

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30 September 2017

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

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30 September 2017

Functional properties of interphotoreceptor retinoid-binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

30 September 2017

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells

1 reference

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30 September 2017

Cloning and expression of murine IL-12

1 reference

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30 September 2017

The Differential Response to Interferon γ by Normal and Transformed Endothelial Cells

1 reference

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30 September 2017

Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

28 June 2018

Experimental autoimmune encephalomyelitis is exacerbated in mice lacking the NOS2 gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

28 June 2018

IL-12 inhibits endotoxin-induced inflammation in the eye.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

28 June 2018

Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

28 June 2018

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

28 June 2018

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

28 June 2018

The adjuvant effect of interleukin-12 in a vaccine against Leishmania major.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

28 June 2018

Priming for high interferon-gamma production induced by interleukin-12 in both CD4 and CD8 T cell clones from HIV-infected patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

28 June 2018

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

28 June 2018

Genetic control of susceptibility to experimental autoimmune uveoretinitis in the mouse model. Concomitant regulation by MHC and non-MHC genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

28 June 2018

IL-10 has a protective role in experimental autoimmune uveoretinitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

21 September 2018

Interferon-gamma confers resistance to experimental allergic encephalomyelitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

21 September 2018

Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

21 September 2018

Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-gamma-producing cells and increased expression of macrophage-associated inducible nitr

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

21 September 2018

Endogenous systemic IFN-gamma has a protective role against ocular autoimmunity in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

21 September 2018

Differential effects of interleukin-12 on the development of naive mouse CD4 T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

21 September 2018

Apoptosis of cultured mouse luteal cells induced by tumor necrosis factor-alpha and interferon-gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

21 September 2018

Pathology of experimental autoimmune uveoretinitis in mice

1 reference

https://api.crossref.org/works/10.1084/JEM.189.2.219

21 January 2018

Regulation of the interaction between Th1 and Th2 T cell clones to provide help for antibody productionin vivo

1 reference

https://api.crossref.org/works/10.1084/JEM.189.2.219

21 January 2018

Germinal center B cells rescued from apoptosis by CD40 ligation or attachment to follicular dendritic cells, but not by engagement of surface immunoglobulin or adhesion receptors, become resistant to CD95-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1084/JEM.189.2.219

21 January 2018

Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a T helper-1-like or a T helper-2-like response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

21 October 2018

IFN-gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

21 October 2018

Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

21 October 2018

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4 T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

21 October 2018

IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-gamma-receptor-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

21 October 2018

T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192986

21 October 2018

Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4 T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of IL-12 on helper T cell-dependent immune responses in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High doses of interleukin-12 inhibit the development of joint disease in DBA/1 mice immunized with type II collagen in complete Freund's adjuvant

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage cytotoxicity against murine meth A sarcoma involves nitric oxide-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptotic nuclei by interferon-gamma and by predesquamin in cultured keratinocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-12 induces human T cells secreting IL-10 with IFN-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-12 promotes cellular but not humoral type II collagen-specific Th 1-type responses in C57BL/6 and B10.Q mice and fails to induce arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of a Th1 disease by a Th1 cytokine: IL-12 and diabetes in NOD mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 prevents nitric oxide-mediated apoptosis and poly(ADP-ribose) polymerase cleavage

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide inhibits the secretion of T-helper 1- and T-helper 2-associated cytokines in activated human T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with downregulation of Bcl-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide and the immunomodulation of experimental allergic encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9892605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.189.2.219

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9892605 AND SRC:MED&resulttype=core&format=json

8 December 2019

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1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9892605 AND SRC:MED&resulttype=core&format=json

8 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9892605 AND SRC:MED&resulttype=core&format=json

8 December 2019

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