Tetraploidy/aneuploidy and stem cells in cancer promotion: The role of chromosome passenger proteins (Q36332561)

13 August 2017

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title

Tetraploidy/aneuploidy and stem cells in cancer promotion: The role of chromosome passenger proteins (English)

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13 August 2017

Hao G Nguyen

1

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Katya Ravid

object named as

Katya Ravid

series ordinal

2

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publication date

1 July 2006

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Journal of Cellular Physiology

13 August 2017

published in

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13 August 2017

volume

208

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13 August 2017

issue

1

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13 August 2017

page(s)

12-22

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Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo.

13 August 2017

cites work

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Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells

21 January 2018

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Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation

21 January 2018

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Chromosomal passengers and the (aurora) ABCs of mitosis

21 January 2018

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INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1

21 January 2018

1 reference

Prospective identification of tumorigenic breast cancer cells

21 January 2018

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A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

21 January 2018

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Mitotic mechanics: the auroras come into view

21 January 2018

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Aurora B regulates MCAK at the mitotic centromere

21 January 2018

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High expression of Aurora-B/Aurora and Ipll-like midbody-associated protein (AIM-1) in astrocytomas

21 January 2018

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Role of p21(Cip1/Waf1) in cell-cycle exit of endomitotic megakaryocytes

21 January 2018

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Polo-like kinases and the orchestration of cell division

21 January 2018

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Mutator phenotype in cancer: timing and perspectives

21 January 2018

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The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast

21 January 2018

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The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.

21 January 2018

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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

21 January 2018

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Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity

21 January 2018

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Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?

21 January 2018

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Inhibitor of apoptosis protein survivin regulates vascular injury.

21 January 2018

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DNA ploidy and survival of patients with clinically localized prostate cancer treated without intent to cure.

21 January 2018

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Managing the centrosome numbers game: from chaos to stability in cancer cell division

21 January 2018

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Mutations of mitotic checkpoint genes in human cancers

21 January 2018

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Genetic instability and darwinian selection in tumours

21 January 2018

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The cellular geography of aurora kinases

21 January 2018

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Survivin is required for stable checkpoint activation in taxol-treated HeLa cells

21 January 2018

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Cell death by mitotic catastrophe: a molecular definition

21 January 2018

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21 January 2018

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Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions

21 January 2018

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Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p

21 January 2018

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Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells

21 January 2018

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Recent advances in molecular pathology. The effects of hypertension on the arterial wall

21 January 2018

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Predictive factors in radiotherapy for non-small cell lung cancer: present status.

21 January 2018

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21 January 2018

Survivin and leukemia

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The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis

21 January 2018

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Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice

21 January 2018

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Loss of heterozygosity in normal tissue adjacent to breast carcinomas.

21 January 2018

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Two mammalian mitotic aurora kinases: who's who?

21 January 2018

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Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle

21 January 2018

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Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

21 January 2018

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Dawn of Aurora kinase inhibitors as anticancer drugs

21 January 2018

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Cell cycle checkpoint function in bladder cancer

21 January 2018

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Aurora kinases in spindle assembly and chromosome segregation

21 January 2018

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Genetic instability of cancer cells is proportional to their degree of aneuploidy

21 January 2018

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Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy

21 January 2018

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Endoreplication cell cycles: more for less

21 January 2018

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Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy

21 January 2018

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A genetic model for colorectal tumorigenesis

21 January 2018

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Timing is everything in life: conditional transgene expression in the cardiovascular system.

21 January 2018

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Aurora-B dysfunction of multinucleated giant cells in glioma detected by site-specific phosphorylated antibodies.

21 January 2018

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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

21 January 2018

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Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extracts

21 January 2018

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17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus

21 January 2018

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Hepatocyte Ploidy in Regenerating Livers after Partial Hepatectomy, Drug-Induced Necrosis, and Cirrhosis

21 January 2018

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Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle

21 January 2018

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Megakaryocytes express functional Aurora-B kinase in endomitosis

21 January 2018

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Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis

21 January 2018

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Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity

21 January 2018

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The centrosome-associated Aurora/Ipl-like kinase family

21 January 2018

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Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process

21 January 2018

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Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53

21 January 2018

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Hepatic polyploidy and liver growth control.

21 January 2018

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Differential requirements for survivin in hematopoietic cell development

21 January 2018

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Rules for making human tumor cells

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.

21 January 2018

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VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

21 January 2018

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The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

21 January 2018

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Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis

21 January 2018

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Vascular smooth muscle polyploidization as a biomarker for aging and its impact on differential gene expression

21 January 2018

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Expression of survivin in astrocytic tumors: correlation with malignant grade and prognosis

21 January 2018

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Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis

21 January 2018

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Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation

21 January 2018

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Tetraploidy in acute myeloid leukemia secondary to large cell lymphoma

21 January 2018

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The Aurora kinases: role in cell transformation and tumorigenesis

21 January 2018

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Thrombopoietin: a tool for understanding thrombopoiesis

21 January 2018

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Aurora-kinase inhibitors as anticancer agents

21 January 2018

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Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1

21 January 2018

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Two genetic hits (more or less) to cancer

21 January 2018

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Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation

21 January 2018

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Expression of different survivin variants in gastric carcinomas: first clues to a role of survivin-2B in tumour progression

21 January 2018

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Correcting improper chromosome-spindle attachments during cell division

21 January 2018

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Genetic instability in colorectal cancers

21 January 2018

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Genetic instabilities in human cancers

21 January 2018

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Endoreduplication and telomeric association in a choroid plexus carcinoma

21 January 2018

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Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

21 January 2018

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Multiple mutations and cancer

21 January 2018

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Polyploidization and centrosome hyperamplification in inflammatory bronchi

21 January 2018

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G1 tetraploidy checkpoint and the suppression of tumorigenesis

21 January 2018

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HBXIP functions as a cofactor of survivin in apoptosis suppression

21 January 2018

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Aneuploidy of human testicular germ cell tumors is associated with amplification of centrosomes.

21 January 2018

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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

21 January 2018

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Aurora kinases link chromosome segregation and cell division to cancer susceptibility

21 January 2018

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Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin

21 January 2018

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The kinase activity of aurora B is required for kinetochore-microtubule interactions during mitosis

21 January 2018

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Survivin an important determinant for prognosis in adult T-cell leukemia: a novel biomarker in practical hemato-oncology

21 January 2018

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Segregating sister genomes: the molecular biology of chromosome separation

21 January 2018

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Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property

21 January 2018

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Mitotic kinases as regulators of cell division and its checkpoints

21 January 2018

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Centrosome aberrations: cause or consequence of cancer progression?

21 January 2018

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The role of chromosomal instability in tumor initiation

21 January 2018

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Heterogeneity, polyploidy, aneusomy, and 9p deletion in human glioblastoma multiforme

21 January 2018

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Human papillomavirus type 16 E6 and E7 cause polyploidy in human keratinocytes and up-regulation of G2-M-phase proteins

21 January 2018

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Separase Regulates INCENP-Aurora B Anaphase Spindle Function Through Cdc14

21 January 2018

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Roads to polyploidy: the megakaryocyte example

21 January 2018

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Asymmetrical segregation of chromosomes with a normal metaphase/anaphase checkpoint in polyploid megakaryocytes

21 January 2018

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The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly

21 January 2018

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Expression of survivin, an inhibitor of apoptosis protein, in tumors of the nervous system

21 January 2018

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A small C-terminal sequence of Aurora B is responsible for localization and function

21 January 2018

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Stem cell origin of cancer and differentiation therapy

21 January 2018

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Telomeres, stem cells, senescence, and cancer

21 January 2018

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Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines.

21 January 2018

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Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability

21 January 2018

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Mammary stem cell repertoire: new insights in aging epithelial populations

21 January 2018

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Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis

21 January 2018

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A single amino acid change (Asp 53 --> Ala53) converts Survivin from anti-apoptotic to pro-apoptotic

21 January 2018

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Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation

21 January 2018

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The somatic mutation theory of cancer: growing problems with the paradigm?

21 January 2018

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p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption

21 January 2018

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From polyploidy to aneuploidy, genome instability and cancer

21 January 2018

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Aurora-B associated protein phosphatases as negative regulators of kinase activation

21 January 2018

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Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death

21 January 2018

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Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/cyclin E complex activation.

21 January 2018

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Ploidy as a prognostic feature in colonic adenocarcinoma

21 January 2018

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Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections

21 January 2018

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Overexpression of Aurora-A potentiates HRAS-mediated oncogenic transformation and is implicated in oral carcinogenesis.

21 January 2018

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Multiple numerical chromosome aberrations in cancer: what are their causes and what are their consequences?

21 January 2018

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Role of chromosomal passenger complex in chromosome segregation and cytokinesis

21 January 2018

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AIM-1: a mammalian midbody-associated protein required for cytokinesis

21 January 2018

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Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

21 January 2018

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INCENP loss from an inactive centromere correlates with the loss of sister chromatid cohesion.

21 January 2018

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Chromosomal passengers: the four-dimensional regulation of mitotic events

21 January 2018

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Structural basis for phosphoserine-proline recognition by group IV WW domains

21 January 2018

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Induction of polyploidy and apoptosis after exposure to high concentrations of the spindle poison nocodazole

21 January 2018

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Kinetochore localization of spindle checkpoint proteins: who controls whom?

21 January 2018

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Cell fusion is the principal source of bone-marrow-derived hepatocytes

21 January 2018

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INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis

21 January 2018

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Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo

21 January 2018

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Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1-deregulated expression

21 January 2018

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Polyploidy: occurrence in nature, mechanisms, and significance for the megakaryocyte-platelet system

21 January 2018

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A Role for Cyclin D3 in the Endomitotic Cell Cycle

21 January 2018

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21 January 2018

Aneuploidy and cancer

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Endopolyploid cells produced after severe genotoxic damage have the potential to repair DNA double strand breaks

21 January 2018

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Chromatin-associated Protein Phosphatase 1 Regulates Aurora-B and Histone H3 Phosphorylation

21 January 2018

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Three cases of near-tetraploid acute myeloid leukemias originating in pluripotent myeloid progenitors

21 January 2018

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Vascular smooth muscle cell polyploidization involves changes in chromosome passenger proteins and an endomitotic cell cycle

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCP.20565

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13 August 2017

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