Targeting integrins for the control of tumour angiogenesis (Q36322066)

13 August 2017

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title

Targeting integrins for the control of tumour angiogenesis (English)

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13 August 2017

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Abebe Akalu

1

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13 August 2017

Alexandra Cretu

series ordinal

2

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13 August 2017

Peter C Brooks

series ordinal

3

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13 August 2017

language of work or name

English

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publication date

1 December 2005

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Expert Opinion on Investigational Drugs

13 August 2017

published in

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13 August 2017

volume

14

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13 August 2017

issue

12

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13 August 2017

page(s)

1475-1486

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Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?

13 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Integrins and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Mechanisms of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Novel vascular endothelial growth factor binding domains of fibronectin enhance vascular endothelial growth factor biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

An angiogenic laminin site and its antagonist bind through the alpha(v)beta3 and alpha5beta1 integrins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Generation of monoclonal antibodies to cryptic collagen sites by using subtractive immunization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

The adaptor protein Shc couples a class of integrins to the control of cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Disruption of Angiogenesis by PEX, a Noncatalytic Metalloproteinase Fragment with Integrin Binding Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Physical association of uPAR with the alphaV integrin on the surface of human NK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Molecular basis of endothelial cell morphogenesis in three-dimensional extracellular matrices

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Cell adhesion molecules in angiogenesis

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.14.12.1475

Integrins: versatile integrators of extracellular signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Integrins: bidirectional, allosteric signaling machines

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.14.12.1475

Integrin structure: new twists and turns in dynamic cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Therapeutic antagonists and conformational regulation of integrin function

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.14.12.1475

Crystal structure of the extracellular segment of integrin alpha Vbeta3

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.14.12.1475

Integrin-linked kinase: integrin's mysterious partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

New functions for non-collagenous domains of human collagen type IV. Novel integrin ligands inhibiting angiogenesis and tumor growth in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Basement membranes: structure, assembly and role in tumour angiogenesis

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.14.12.1475

Endogenous inhibitors of angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Matrix revolutions: "tails" of basement-membrane components with angiostatic functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Cleavage of the matricellular protein SPARC by matrix metalloproteinase 3 produces polypeptides that influence angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

CNTO 95, a fully human monoclonal antibody that inhibits alphav integrins, has antitumor and antiangiogenic activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Insights into extracellular matrix functions from mutant mouse models

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.14.12.1475

Angiogenesis promoted by vascular endothelial growth factor: Regulation through α1β1and α2β1 integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Functions of alpha3beta1 integrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Synergistic effect of TNF-alpha in soluble VCAM-1-induced angiogenesis through alpha 4 integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

alpha5beta1 integrin stimulates Bcl-2 expression and cell survival through Akt, focal adhesion kinase, and Ca2 /calmodulin-dependent protein kinase IV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Endostatin is a potential inhibitor of Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating alphavbeta3-integrin and activating VEGF-R2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

VEGF-integrin interplay controls tumor growth and vascularization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Interaction between insulin-like growth factor-I receptor and alphaVbeta3 integrin linked signaling pathways: cellular responses to changes in multiple signaling inputs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Identification of a candidate integrin-fraction associated with the activated form of the PDGF-receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

A fibronectin fragment inhibits tumor growth, angiogenesis, and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Regulation of tumor angiogenesis by fastatin, the fourth FAS1 domain of betaig-h3, via alphavbeta3 integrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Loss of p53 compensates for alpha v-integrin function in retinal neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Induction of Cell Migration by Matrix Metalloprotease-2 Cleavage of Laminin-5

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Overexpression of laminin-5 gamma2 chain and its prognostic significance in urothelial carcinoma of urinary bladder: association with expression of cyclooxygenase 2, epidermal growth factor receptor [corrected] and human epidermal growth factor rece

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Diagnostic and therapeutic applications of recombinant antibodies: targeting the extra-domain B of fibronectin, a marker of tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

Integrin β4 signaling promotes tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.14.12.1475

10.1517/13543784.14.12.1475

21 January 2018

Identifiers

DOI

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13 August 2017

1 reference