Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells (Q36304128)

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English	Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Michael P. Lisanti

8

object named as

Michael P Lisanti

1 reference

Europe PubMed Central

13 August 2017

PMC publication ID

Federica Sotgia

7

object named as

Federica Sotgia

1 reference

Europe PubMed Central

13 August 2017

PMC publication ID

Diana Whitaker-Menezes

3

object named as

Diana Whitaker-Menezes

1 reference

Europe PubMed Central

13 August 2017

PMC publication ID

Herbert B Tanowitz

5

object named as

Herbert B Tanowitz

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Richard Pestell

6

object named as

Richard G Pestell

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Ubaldo E Martinez-Outschoorn

2

object named as

Ubaldo E Martinez-Outschoorn

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Barbara Chiavarina

1

object named as

Barbara Chiavarina

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

4

object named as

Anthony Howell

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

publication date

16 August 2012

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

11

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

17

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

3280-3289

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466527

30 September 2017

Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth

1 reference

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30 September 2017

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue

1 reference

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30 September 2017

Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection

1 reference

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30 September 2017

Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms

1 reference

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30 September 2017

Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment

1 reference

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30 September 2017

Hypoxia-Inducible Factor-2α Regulates GM-CSF–Derived Soluble Vascular Endothelial Growth Factor Receptor 1 Production from Macrophages and Inhibits Tumor Growth and Angiogenesis

1 reference

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30 September 2017

The Hypoxia-Associated Factor Switches Cells from HIF-1α- to HIF-2α-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion

1 reference

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30 September 2017

PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types

1 reference

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30 September 2017

HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466527

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Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

1 reference

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30 September 2017

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

1 reference

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30 September 2017

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466527

30 September 2017

HIF-2alpha-mediated activation of the epidermal growth factor receptor potentiates head and neck cancer cell migration in response to hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466527

30 September 2017

Stromal cell expression of caveolin-1 predicts outcome in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466527

30 September 2017

An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466527

30 September 2017

Hypoxia-inducible factor-2alpha correlates to distant recurrence and poor outcome in invasive breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466527

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The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

1 reference

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30 September 2017

Prognostic significance of HIF-2alpha/EPAS1 expression in hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466527

30 September 2017

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466527

30 September 2017

Neuron-glia metabolic coupling and plasticity

1 reference

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30 September 2017

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466527

30 September 2017

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466527

30 September 2017

The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466527

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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

1 reference

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Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1.

1 reference

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Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

1 reference

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The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice

1 reference

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Lactate shuttles in nature

1 reference

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Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts

1 reference

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Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth

1 reference

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21 January 2018

Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression.

1 reference

https://api.crossref.org/works/10.4161/CC.21643

21 January 2018

Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial.

1 reference

https://api.crossref.org/works/10.4161/CC.21643

21 January 2018

Correlations of hypoxia-inducible factor-1α/hypoxia-inducible factor-2α expression with angiogenesis factors expression and prognosis in non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22894905

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deregulation of HIF1-alpha and hypoxia-regulated pathways in hepatocellular carcinoma and corresponding non-malignant liver tissue--influence of a modulated host stroma on the prognosis of HCC

1 reference

https://pubmed.ncbi.nlm.nih.gov/22894905

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4161/CC.21643

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

ResearchGate publication ID

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