Drugs, QTc interval prolongation and final ICH E14 guideline : an important milestone with challenges ahead (Q36289359)

13 August 2017

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title

Drugs, QTc interval prolongation and final ICH E14 guideline : an important milestone with challenges ahead (English)

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13 August 2017

Rashmi R Shah

1

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13 August 2017

publication date

1 January 2005

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13 August 2017

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13 August 2017

volume

28

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13 August 2017

issue

11

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13 August 2017

page(s)

1009-1028

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Relation between QT and RR intervals is highly individual among healthy subjects: implications for heart rate correction of the QT interval

13 August 2017

cites work

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12 December 2020

Nonclinical proarrhythmia models: predicting Torsades de Pointes

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12 December 2020

Preclinical strategies to assess QT liability and torsadogenic potential of new drugs: the role of experimental models

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Comparative efficacy and safety of oral mexiletine and quinidine in benign or potentially lethal ventricular arrhythmias

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QT interval prolongation after oxytocin bolus during surgical induced abortion

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12 December 2020

Spectrum and prevalence of cardiac sodium channel variants among black, white, Asian, and Hispanic individuals: implications for arrhythmogenic susceptibility and Brugada/long QT syndrome genetic testing

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12 December 2020

The significance of QT interval in drug development

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12 December 2020

The use of electrocardiograms in clinical trials: a public discussion of the proposed ICH E14 regulatory guidance. April 11-12, 2005, Bethesda, MD, USA

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12 December 2020

Cardiac repolarization. The long and short of it.

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12 December 2020

Mechanisms of arsenic-induced prolongation of cardiac repolarization

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Gender differences in autonomic modulation of ventricular repolarization in humans

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12 December 2020

Comparing methods of measurement for detecting drug-induced changes in the QT interval: implications for thoroughly conducted ECG studies.

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12 December 2020

Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity

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Sotalol, hypokalaemia, syncope, and torsade de pointes

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12 December 2020

The effect of acute hyperglycaemia on QTc duration in healthy man

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12 December 2020

New preclinical guidelines on drug effects on ventricular repolarization: safety pharmacology comes of age.

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12 December 2020

Drug-induced QT prolongation in women during the menstrual cycle

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12 December 2020

QT-RR relationship in healthy subjects exhibits substantial intersubject variability and high intrasubject stability

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12 December 2020

Ethnic differences in electrocardiographic intervals and axes

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12 December 2020

Ventricular tachycardia after oxytocin injection in patients with prolonged Q-T interval syndrome--report of two cases

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12 December 2020

Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K channel

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12 December 2020

Agreement and reproducibility of automatic versus manual measurement of QT interval and QT dispersion

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12 December 2020

Sex differences in ventricular repolarization: from cardiac electrophysiology to Torsades de Pointes

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12 December 2020

Towards a drug concentration effect relationship for QT prolongation and torsades de pointes

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12 December 2020

Clinical characteristics and treatment of short QT syndrome

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12 December 2020

Ethnic differences in cardiac potassium channel variants: implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndrome

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Exploring the hidden danger of noncardiac drugs

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Pentamidine-induced long QT syndrome and block of hERG trafficking

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Drugs effects on ventricular repolarization: a critical evaluation of the strengths and weaknesses of current methodologies and regulatory practices

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A mechanistic approach to assess the proarrhythmic risk of QT-prolonging drugs in preclinical pharmacologic studies

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Genetic susceptibility to acquired long QT syndrome: pharmacologic challenge in first-degree relatives

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Electrocardiographic identification of drug-induced QT prolongation: assessment by different recording and measurement methods.

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12 December 2020

The imprecision in heart rate correction may lead to artificial observations of drug induced QT interval changes

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12 December 2020

Drugs, QT interval prolongation and ICH E14: the need to get it right

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12 December 2020

Torsade de pointes in a patient receiving intravenous vasopressin

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12 December 2020

HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk

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12 December 2020

Recent advances in understanding sex differences in cardiac repolarization.

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12 December 2020

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

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12 December 2020

Dynamic beat-to-beat modeling of the QT-RR interval relationship: analysis of QT prolongation during alterations of autonomic state versus human ether a-go-go-related gene inhibition

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12 December 2020

Greater quinidine-induced QTc interval prolongation in women

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12 December 2020

The combined use of ibutilide as an active control with intensive electrocardiographic sampling and signal averaging as a sensitive method to assess the effects of tadalafil on the human QT interval

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12 December 2020

10.2165/00002018-200528110-00003

Identifiers

DOI

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Dimensions Publication ID

13 August 2017

1026069519

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