Spectroscopic and theoretical approaches for studying radical reactions in class I ribonucleotide reductase (Q36283688)

13 August 2017

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title

Spectroscopic and theoretical approaches for studying radical reactions in class I ribonucleotide reductase (English)

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13 August 2017

2

Friedhelm Lendzian

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4

Hendrik Zipse

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13 August 2017

1

Marina Bennati

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13 August 2017

Michael Schmittel

3

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13 August 2017

publication date

1 October 2005

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13 August 2017

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volume

386

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issue

10

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13 August 2017

page(s)

1007-1022

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Theoretical and electrochemical analysis of dissociative electron transfers proceeding through formation of loose radical anion species: reduction of symmetrical and unsymmetrical disulfides

13 August 2017

cites work

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Mechanistic studies on the hydroxylation of methane by methane monooxygenase.

21 January 2018

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Rational reprogramming of the R2 subunit of Escherichia coli ribonucleotide reductase into a self-hydroxylating monooxygenase.

21 January 2018

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Structural characterization of the peroxodiiron(III) intermediate generated during oxygen activation by the W48A/D84E variant of ribonucleotide reductase protein R2 from Escherichia coli

21 January 2018

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High-frequency (140-GHz) time domain EPR and ENDOR spectroscopy: the tyrosyl radical-diiron cofactor in ribonucleotide reductase from yeast

21 January 2018

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Pulsed ELDOR spectroscopy measures the distance between the two tyrosyl dadicals in the R2 subunit of the E. coli ribonucleotide reductase

21 January 2018

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Tryptophan and tyrosine radicals in ribonucleotide reductase: a comparative high-field EPR study at 94 GHz.

21 January 2018

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Mechanism of assembly of the tyrosyl radical-dinuclear iron cluster cofactor of ribonucleotide reductase.

21 January 2018

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Ribonucleotide activation by enzyme ribonucleotide reductase: understanding the role of the enzyme.

21 January 2018

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Turning on ribonucleotide reductase by light-initiated amino acid radical generation

21 January 2018

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Carboxyl-terminal peptides as probes for Escherichia coli ribonucleotide reductase subunit interaction: kinetic analysis of inhibition studies

21 January 2018

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Site-directed mutagenesis and deletion of the carboxyl terminus of Escherichia coli ribonucleotide reductase protein R2. Effects on catalytic activity and subunit interaction.

21 January 2018

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Inactivation of Escherichia coli ribonucleotide reductase by 2'-deoxy-2'-mercaptouridine 5'-diphosphate. Electron paramagnetic resonance evidence for a transient protein perthiyl radical.

21 January 2018

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Two conserved tyrosine residues in protein R1 participate in an intermolecular electron transfer in ribonucleotide reductase.

21 January 2018

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Preserved catalytic activity in an engineered ribonucleotide reductase R2 protein with a nonphysiological radical transfer pathway. The importance of hydrogen bond connections between the participating residues

21 January 2018

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Structure and function of the radical enzyme ribonucleotide reductase

21 January 2018

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Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding

21 January 2018

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Deoxyribonucleotide synthesis in anaerobic microorganisms: the class III ribonucleotide reductase

21 January 2018

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Structure of the nitrogen-centered radical formed during inactivation of E. coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine-5'-diphosphate: trapping of the 3'-ketonucleotide

21 January 2018

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Pre-steady-state and steady-state kinetic analysis of E. coli class I ribonucleotide reductase

21 January 2018

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Density functional study of a micro-1,1-carboxylate bridged Fe(III)-O-Fe(IV) model complex. 2. Comparison with ribonucleotide reductase intermediate X.

21 January 2018

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Density functional calculations on model tyrosyl radicals

21 January 2018

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Displacement of the tyrosyl radical cofactor in ribonucleotide reductase obtained by single-crystal high-field EPR and 1.4-A x-ray data

21 January 2018

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The radical site in chlamydial ribonucleotide reductase defines a new R2 subclass

21 January 2018

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Comprehensive model for allosteric regulation of mammalian ribonucleotide reductase: refinements and consequences

21 January 2018

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The conserved active site asparagine in class I ribonucleotide reductase is essential for catalysis

21 January 2018

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A new tyrosyl radical on Phe208 as ligand to the diiron center in Escherichia coli ribonucleotide reductase, mutant R2-Y122H. Combined x-ray diffraction and EPR/ENDOR studies

21 January 2018

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High-field EPR detection of a disulfide radical anion in the reduction of cytidine 5'-diphosphate by the E441Q R1 mutant of Escherichia coli ribonucleotide reductase

21 January 2018

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Structure and interactions of amino acid radicals in class I ribonucleotide reductase studied by ENDOR and high-field EPR spectroscopy

21 January 2018

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Thiyl radicals in ribonucleotide reductases.

21 January 2018

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New paramagnetic species formed at the expense of the transient tyrosyl radical in mutant protein R2 F208Y of Escherichia coli ribonucleotide reductase.

21 January 2018

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Crystal structures of two self-hydroxylating ribonucleotide reductase protein R2 mutants: structural basis for the oxygen-insertion step of hydroxylation reactions catalyzed by diiron proteins

21 January 2018

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Demonstration of segmental mobility in the functionally essential car☐yl terminal part of ribonucleotide reductase protein R2 from Escherichia coli

21 January 2018

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1H NMR studies of mouse ribonucleotide reductase: the R2 protein carboxyl-terminal tail, essential for subunit interaction, is highly flexible but becomes rigid in the presence of protein R1

21 January 2018

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Interaction of C225SR1 mutant subunit of ribonucleotide reductase with R2 and nucleoside diphosphates: tales of a suicidal enzyme

21 January 2018

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Characterization of C439SR1, a mutant of Escherichia coli ribonucleotide diphosphate reductase: evidence that C439 is a residue essential for nucleotide reduction and C439SR1 is a protein possessing novel thioredoxin-like activity

21 January 2018

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Crystallization and crystallographic investigations of the small subunit of mouse ribonucleotide reductase

21 January 2018

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Structure and function of the Escherichia coli ribonucleotide reductase protein R2

21 January 2018

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Three-dimensional structure of the free radical protein of ribonucleotide reductase

21 January 2018

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Structural, CV and IR spectroscopic evidences for preorientation in PET-active phthalimido carboxylic acids.

21 January 2018

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Class I ribonucleotide reductase revisited: the effect of removing a proton on Glu441.

21 January 2018

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Theoretical study of ribonucleotide reductase mechanism-based inhibition by 2'-azido-2'-deoxyribonucleoside 5'-diphosphates

21 January 2018

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A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase

21 January 2018

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From RNA to DNA, why so many ribonucleotide reductases?

21 January 2018

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Alternative model for mechanism-based inhibition of Escherichia coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine 5'-diphosphate.

21 January 2018

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Genomic cloning and characterization of the human thrombin receptor gene. Structural similarity to the proteinase activated receptor-2 gene

21 January 2018

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A quantitative model for allosteric control of purine reduction by murine ribonucleotide reductase

21 January 2018

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Structures of the yeast ribonucleotide reductase Rnr2 and Rnr4 homodimers

21 January 2018

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Crystal structural studies of changes in the native dinuclear iron center of ribonucleotide reductase protein R2 from mouse

21 January 2018

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Protein radical involvement in biological catalysis?

21 January 2018

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Radical initiation in the class I ribonucleotide reductase: long-range proton-coupled electron transfer?

21 January 2018

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Structure of ribonucleotide reductase protein R1

21 January 2018

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Sensitivity of tyrosyl radical g-values to changes in protein structure: a high-field EPR study of mutants of ribonucleotide reductase.

21 January 2018

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Inactivation of ribonucleotide reductase by (E)-2'-fluoromethylene-2'-deoxycytidine 5'-diphosphate: a paradigm for nucleotide mechanism-based inhibitors.

21 January 2018

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Structure of the yeast ribonucleotide reductase Y2Y4 heterodimer

21 January 2018

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A stable FeIII-FeIV replacement of tyrosyl radical in a class I ribonucleotide reductase

21 January 2018

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Facile electron transfer during formation of cluster X and kinetic competence of X for tyrosyl radical production in protein R2 of ribonucleotide reductase from mouse

21 January 2018

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The influence of hydrogen bonding interactions on the C-H bond activation step in class I ribonucleotide reductases

21 January 2018

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Mechanism of Rapid Electron Transfer during Oxygen Activation in the R2 Subunit ofEscherichiacoliRibonucleotide Reductase. 1. Evidence for a Transient Tryptophan Radical

21 January 2018

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New insights into a critical biological control step of the mechanism of Ribonucleotide reductase

21 January 2018

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Theoretical Studies on the Mode of Inhibition of Ribonucleotide Reductase by 2′-Substituted Substrate Analogues

21 January 2018

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Mechanism of Rapid Electron Transfer during Oxygen Activation in the R2 Subunit ofEscherichiacoliRibonucleotide Reductase. 2. Evidence for and Consequences of Blocked Electron Transfer in the W48F Variant

21 January 2018

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Heterogeneity of the Local Electrostatic Environment of the Tyrosyl Radical inMycobacterium tuberculosisRibonucleotide Reductase Observed by High-Field Electron Paramagnetic Resonance

21 January 2018

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Theoretical Study on the Inhibition of Ribonucleotide Reductase by 2‘-Mercapto-2‘-deoxyribonucleoside-5‘-diphosphates

21 January 2018

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21 January 2018

Identifiers

DOI

10.1515/BC.2005.117

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13 August 2017

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