The ERK cascade: a prototype of MAPK signaling (Q36260506)

13 August 2017

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title

The ERK cascade: a prototype of MAPK signaling (English)

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13 August 2017

Hadara Rubinfeld

1

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13 August 2017

Rony Seger

series ordinal

2

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13 August 2017

publication date

1 October 2005

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13 August 2017

published in

Molecular Biotechnology

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13 August 2017

volume

31

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13 August 2017

issue

2

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13 August 2017

page(s)

151-174

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Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

13 August 2017

cites work

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12 December 2020

ERK7 is an autoactivated member of the MAPK family

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12 December 2020

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

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12 December 2020

MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous.

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12 December 2020

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro

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12 December 2020

Isolation and characterization of two growth factor-stimulated protein kinases that phosphorylate the epidermal growth factor receptor at threonine 669

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12 December 2020

A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun

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12 December 2020

High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21Cip1

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12 December 2020

Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells

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12 December 2020

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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12 December 2020

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

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12 December 2020

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

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12 December 2020

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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12 December 2020

Counting on mitogen-activated protein kinases--ERKs 3, 4, 5, 6, 7 and 8.

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12 December 2020

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

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12 December 2020

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

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12 December 2020

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

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12 December 2020

Signal transduction and oncogenesis by ErbB/HER receptors

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12 December 2020

PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization

1 reference

12 December 2020

Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2

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12 December 2020

Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes

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12 December 2020

Heterogeneous expression of four MAP kinase isoforms in human tissues

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12 December 2020

Specific and differential activation of mitogen-activated protein kinase cascades by unfamiliar taste in the insular cortex of the behaving rat.

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12 December 2020

A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila

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12 December 2020

Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase

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12 December 2020

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

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12 December 2020

MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation

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12 December 2020

Negative Feedback Regulation and Desensitization of Insulin- and Epidermal Growth Factor-stimulated p21ras Activation

1 reference

12 December 2020

In search of new mutants in cell-signaling systems of the nematode Caenorhabditis elegans. Review

1 reference

12 December 2020

MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway

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12 December 2020

PAC-1: a Mitogen-Induced Nuclear Protein Tyrosine Phosphatase

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12 December 2020

Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases

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12 December 2020

Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase

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12 December 2020

BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

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12 December 2020

Detection of ERK activation by a novel monoclonal antibody

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12 December 2020

Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase

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12 December 2020

MAPK signal pathways in the regulation of cell proliferation in mammalian cells

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12 December 2020

Protein kinase C alpha activates RAF-1 by direct phosphorylation

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12 December 2020

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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12 December 2020

Clinical implications of the p53 gene

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12 December 2020

Activation of MAP kinases, pp90rsk and pp70-S6 kinases in mouse mast cells by signaling through the c-kit receptor tyrosine kinase or Fc epsilon RI: rapamycin inhibits activation of pp70-S6 kinase and proliferation in mouse mast cells

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12 December 2020

Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

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12 December 2020

The MAPK signaling cascade

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12 December 2020

MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

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12 December 2020

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

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12 December 2020

The protein kinase complement of the human genome

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12 December 2020

Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia.

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12 December 2020

The p38 signal transduction pathway: activation and function

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12 December 2020

Induction of the mitogen-activated protein kinase phosphatase MKP3 by nerve growth factor in differentiating PC12

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12 December 2020

Regulation of extracellular signal-regulated protein kinase-1 (ERK-1; pp44/mitogen-activated protein kinase) by epidermal growth factor and nerve growth factor in PC12 cells: implication of ERK1 inhibitory activities

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12 December 2020

A conserved docking motif in MAP kinases common to substrates, activators and regulators

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12 December 2020

Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults

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12 December 2020

MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5

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12 December 2020

Cytoplasmic localization of mitogen-activated protein kinase kinase directed by its NH2-terminal, leucine-rich short amino acid sequence, which acts as a nuclear export signal

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12 December 2020

Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo

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12 December 2020

MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation

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12 December 2020

Mixed-lineage kinase control of JNK and p38 MAPK pathways

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12 December 2020

Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway

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12 December 2020

Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal To stimulate DNA synthesis

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12 December 2020

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

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12 December 2020

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

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12 December 2020

MEK7-dependent activation of p38 MAP kinase in keratinocytes

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12 December 2020

Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).

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12 December 2020

Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor

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12 December 2020

Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals

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12 December 2020

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

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12 December 2020

Induction of apoptosis by SLK, a Ste20-related kinase

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12 December 2020

MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway

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12 December 2020

Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases

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12 December 2020

Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase

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12 December 2020

Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus

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12 December 2020

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)

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12 December 2020

PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

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12 December 2020

Ets ternary complex transcription factors

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12 December 2020

Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

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12 December 2020

Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase

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12 December 2020

Novel role for JNK as a stress-activated Bcl2 kinase

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12 December 2020

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

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12 December 2020

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

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12 December 2020

MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain

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12 December 2020

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

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12 December 2020

A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission

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12 December 2020

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation

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12 December 2020

The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product

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12 December 2020

Induction of metaphase arrest in cleaving Xenopus embryos by MAP kinase

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12 December 2020

Cooperating oncogenes converge to regulate cyclin/cdk complexes.

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12 December 2020

Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains

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12 December 2020

Association of mitogen-activated protein kinase with the microtubule cytoskeleton

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12 December 2020

The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo

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12 December 2020

Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies

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12 December 2020

Role of BMK1 in regulation of growth factor-induced cellular responses

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12 December 2020

TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton

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12 December 2020

Mammalian MAP kinase signalling cascades

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12 December 2020

Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades

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12 December 2020

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

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12 December 2020

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

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12 December 2020

Protein-protein interactions in the regulation of the extracellular signal-regulated kinase

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12 December 2020

The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation

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12 December 2020

Biochemical and biological functions of the N-terminal, noncatalytic domain of extracellular signal-regulated kinase 2.

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12 December 2020

ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation

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12 December 2020

Cooperation between oncogenes

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12 December 2020

Signaling via Mitogen-Activated Protein Kinase Kinase (MEK1) Is Required for Golgi Fragmentation during Mitosis

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12 December 2020

Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity

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12 December 2020

ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK

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12 December 2020

Inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells

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12 December 2020

Identification and characterization of a novel MAP kinase kinase kinase, MLTK

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12 December 2020

Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth

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12 December 2020

De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase

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12 December 2020

The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases.

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12 December 2020

Dual specificity phosphatases: a gene family for control of MAP kinase function.

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12 December 2020

Phosphorylation of MAP Kinases by MAP/ERK Involves Multiple Regions of MAP Kinases

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12 December 2020

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif.

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12 December 2020

Detection of partially phosphorylated forms of ERK by monoclonal antibodies reveals spatial regulation of ERK activity by phosphatases

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12 December 2020

DCX, a new mediator of the JNK pathway

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12 December 2020

Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway

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12 December 2020

Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs

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12 December 2020

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

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12 December 2020

ERK5 is a novel type of mitogen-activated protein kinase containing a transcriptional activation domain

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12 December 2020

Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

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12 December 2020

Nuclear localization of mitogen-activated protein kinase kinase 1 (MKK1) is promoted by serum stimulation and G2-M progression. Requirement for phosphorylation at the activation lip and signaling downstream of MKK.

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12 December 2020

Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains

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12 December 2020

A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1.

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12 December 2020

SPAK, a STE20/SPS1-related kinase that activates the p38 pathway

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12 December 2020

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

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12 December 2020

The RAF proteins take centre stage

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12 December 2020

Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

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12 December 2020

The MAP kinase cascade

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12 December 2020

Wiring diagrams of MAPK regulation by MEKK1, 2, and 3.

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12 December 2020

Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts

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12 December 2020

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

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12 December 2020

Protein phosphatases and the regulation of MAP kinase activity

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12 December 2020

MAPKAPK5, a Novel Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase, Is a Substrate of the Extracellular-Regulated Kinase (ERK) and p38 Kinase

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12 December 2020

Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm

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12 December 2020

Meiotic maturation in Xenopus requires polyadenylation of multiple mRNAs

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12 December 2020

Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases

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12 December 2020

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

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12 December 2020

UVA induces Ser381 phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK pathways

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12 December 2020

Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

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12 December 2020

Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis

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12 December 2020

Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion

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12 December 2020

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

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12 December 2020

Ordered phosphorylation of p42mapk by MAP kinase kinase

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12 December 2020

Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases.

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12 December 2020

The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation.

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12 December 2020

MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src

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12 December 2020

A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase

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12 December 2020

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase

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12 December 2020

Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions

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12 December 2020

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

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12 December 2020

Altered regulation of ERK1b by MEK1 and PTP-SL and modified Elk1 phosphorylation by ERK1b are caused by abrogation of the regulatory C-terminal sequence of ERKs

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12 December 2020

Phosphorylation of paxillin via the ERK mitogen-activated protein kinase cascade in EL4 thymoma cells

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12 December 2020

Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells

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12 December 2020

ERK8, a new member of the mitogen-activated protein kinase family

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12 December 2020

A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway

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12 December 2020

Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53.

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12 December 2020

Stopping and going with p27kip1.

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12 December 2020

Components of a new human protein kinase signal transduction pathway

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12 December 2020

Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor

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12 December 2020

Molecular interpretation of ERK signal duration by immediate early gene products

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12 December 2020

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase

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12 December 2020

Molecular Cloning and Functional Expression of a cDNA Encoding a New Member of Mixed Lineage Protein Kinase from Human Brain

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12 December 2020

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

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12 December 2020

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1

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12 December 2020

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

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12 December 2020

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

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12 December 2020

A specific activation of the mitogen-activated protein kinase kinase 1 (MEK1) is required for Golgi fragmentation during mitosis

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12 December 2020

Activation of stress-activated protein kinase/c-Jun N-terminal kinase, but not NF-kappaB, by the tumor necrosis factor (TNF) receptor 1 through a TNF receptor-associated factor 2- and germinal center kinase related-dependent pathway

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12 December 2020

HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway

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12 December 2020

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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12 December 2020

Muscle proteins related to microtubule associated protein-2 are substrates for an insulin-stimulatable kinase

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12 December 2020

c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1.

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12 December 2020

The requirement of both extracellular regulated kinase and p38 mitogen-activated protein kinase for stimulation of cytosolic phospholipase A(2) activity by either FcgammaRIIA or FcgammaRIIIB in human neutrophils. A possible role for Pyk2 but not for

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12 December 2020

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

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12 December 2020

Raf-1 activates MAP kinase-kinase

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12 December 2020

Nuclear localization and regulation of erk- and rsk-encoded protein kinases

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12 December 2020

Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase.

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12 December 2020

Identification of MAP kinase domains by redirecting stress signals into growth factor responses

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12 December 2020

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

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12 December 2020

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

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12 December 2020

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

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12 December 2020

Regulation of the MAP kinase cascade in PC12 cells: B-Raf activates MEK-1 (MAP kinase or ERK kinase) and is inhibited by cAMP

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12 December 2020

Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

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12 December 2020

Identification of a cytoplasmic-retention sequence in ERK2

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12 December 2020

Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2

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12 December 2020

Ion channels as physiological effectors for growth factor receptor and Ras/ERK signaling pathways.

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12 December 2020

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

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12 December 2020

Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin

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12 December 2020

Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve

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12 December 2020

Non-regulated and stimulated mechanisms cooperate in the nuclear accumulation of MEK1.

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12 December 2020

Activation mechanism and function of the MAP kinase cascade

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12 December 2020

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK

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12 December 2020

Signal transduction by the JNK group of MAP kinases

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12 December 2020

Hydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper docking

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12 December 2020

Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function

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12 December 2020

The sevenmaker gain-of-function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action

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12 December 2020

Regulation of Raf-1 by direct feedback phosphorylation.

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12 December 2020

Extracellular-signal-regulated kinase signalling in neurons

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12 December 2020

Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism

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12 December 2020

Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling

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12 December 2020

Senescence of human fibroblasts induced by oncogenic Raf.

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12 December 2020

The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells

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12 December 2020

NESK, a member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and is expressed during the late stages of embryogenesis

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12 December 2020

A Bipartite Mechanism for ERK2 Recognition by Its Cognate Regulators and Substrates

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12 December 2020

Identification of a C-terminal region that regulates mitogen-activated protein kinase kinase-1 cytoplasmic localization and ERK activation

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12 December 2020

ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ

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12 December 2020

Primary Structure of BMK1: A New Mammalian MAP Kinase

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12 December 2020

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

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12 December 2020

Integration of MAP kinase signal transduction pathways at the serum response element

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12 December 2020

Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII

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12 December 2020

Selective requirement for MAP kinase activation in thymocyte differentiation

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12 December 2020

The stress-activated protein kinase subfamily of c-Jun kinases

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12 December 2020

p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2

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12 December 2020

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12 December 2020

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

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12 December 2020

Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells.

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12 December 2020

PRAK, a novel protein kinase regulated by the p38 MAP kinase

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12 December 2020

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

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12 December 2020

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

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12 December 2020

Isotype-specific functions of Raf kinases

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12 December 2020

The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases

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12 December 2020

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

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12 December 2020

Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death.

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12 December 2020

Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif

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12 December 2020

Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase

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12 December 2020

Pheromone response, mating and cell biology

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12 December 2020

Determination of v-Mos-catalyzed phosphorylation sites and autophosphorylation sites on MAP kinase kinase by ESI/MS.

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12 December 2020

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

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12 December 2020

The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions

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12 December 2020

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

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12 December 2020

BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase

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12 December 2020

ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry

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12 December 2020

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

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12 December 2020

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

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12 December 2020

Involvement of the activation loop of ERK in the detachment from cytosolic anchoring

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12 December 2020

Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation

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12 December 2020

Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation

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12 December 2020

Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts.

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12 December 2020

Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1

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12 December 2020

Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulation

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12 December 2020

Characterization of the structure and function of a novel MAP kinase kinase (MKK6)

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12 December 2020

The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases

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12 December 2020

cPLA2 is phosphorylated and activated by MAP kinase

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12 December 2020

Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development

1 reference

12 December 2020

In Situ Activation Pattern of Drosophila EGF Receptor Pathway During Development

1 reference

12 December 2020

Differential tyrosyl-phosphorylation of multiple mitogen-activated protein kinase isoforms in response to prolactin in Nb2 lymphoma cells

1 reference

12 December 2020

Dual leucine zipper-bearing kinase (DLK) activates p46SAPK and p38mapk but not ERK2.

1 reference

12 December 2020

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

1 reference

12 December 2020

PTP-ER, a novel tyrosine phosphatase, functions downstream of Ras1 to downregulate MAP kinase during Drosophila eye development

1 reference

12 December 2020

Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase

1 reference

12 December 2020

A novel regulatory mechanism in the mitogen-activated protein (MAP) kinase cascade. Role of nuclear export signal of MAP kinase kinase.

1 reference

12 December 2020

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21Cip1

1 reference

12 December 2020

The unique C-terminal tail of the mitogen-activated protein kinase ERK5 regulates its activation and nuclear shuttling.

1 reference

12 December 2020

The Ste20 group kinases as regulators of MAP kinase cascades

1 reference

12 December 2020

Identifiers

DOI

10.1385/MB:31:2:151

1 reference

Dimensions Publication ID

13 August 2017

1047011336

0 references

1 reference