A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations (Q36245163)

13 August 2017

A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations (English)

1 reference

13 August 2017

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26398937 AND SRC:MED&resulttype=core&format=json

3 June 2020

Matthias Ernst

14

1 reference

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3 June 2020

15

Klaus-Peter Janssen

1 reference

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3 June 2020

author name string

Michael Buchert

1

1 reference

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3 June 2020

Franziska Rohde

2

1 reference

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3 June 2020

Moritz Eissmann

3

1 reference

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3 June 2020

Niall Tebbutt

4

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3 June 2020

Ben Williams

5

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3 June 2020

Alexander Owen

7

1 reference

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3 June 2020

Yumiko Hirokawa

8

1 reference

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3 June 2020

Alexandra Gnann

9

1 reference

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3 June 2020

Gertraud Orend

10

1 reference

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3 June 2020

Gayle Orner

11

1 reference

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3 June 2020

Rod H Dashwood

12

1 reference

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3 June 2020

Joan K Heath

13

1 reference

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3 June 2020

publication date

6 August 2015

1 reference

Disease Models & Mechanisms

13 August 2017

1 reference

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3 June 2020

volume

8

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3 June 2020

issue

11

1 reference

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3 June 2020

page(s)

1361-1373

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26398937 AND SRC:MED&resulttype=core&format=json

Creative Commons Attribution 3.0 Unported

3 June 2020

copyright license

start time

18 May 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4631784/fullTextXML

inferred from PubMed Central ID database lookup

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A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

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1 October 2017

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1 October 2017

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Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response

1 October 2017

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Crypt stem cells as the cells-of-origin of intestinal cancer

1 October 2017

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A genetic study of the role of the Wnt/beta-catenin signalling in Paneth cell differentiation.

1 October 2017

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Myc deletion rescues Apc deficiency in the small intestine

1 October 2017

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Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis

1 October 2017

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APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression

1 October 2017

1 reference

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Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo

1 October 2017

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Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein

1 October 2017

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The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin

1 October 2017

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The role of prostaglandins and other eicosanoids in the gastrointestinal tract

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Wnt signalling induces maturation of Paneth cells in intestinal crypts

1 October 2017

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Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

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Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

1 October 2017

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1 October 2017

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Effects of Forced Expression of an NH2-terminal Truncated β-Catenin on Mouse Intestinal Epithelial Homeostasis

1 October 2017

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1 October 2017

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The adenomatous polyposis coli (APC) tumor suppressor

1 October 2017

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The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily

1 October 2017

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Purification and characterization of a novel restricted antigen expressed by normal and transformed human colonic epithelium.

1 October 2017

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Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

1 October 2017

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A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

1 October 2017

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A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines

1 October 2017

1 reference

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 October 2017

1 reference

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Aberrant crypts: potential preneoplastic lesions in the murine colon

1 October 2017

1 reference

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APC mutations occur early during colorectal tumorigenesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4631784

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

1 October 2017

1 reference

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Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4631784

Modeling Wnt/β-Catenin Target Gene Expression in APC and Wnt Gradients Under Wild Type and Mutant Conditions

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4631784

Translational efficiency of EMCV IRES in bicistronic vectors is dependent upon IRES sequence and gene location

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4631784

Characterization of mouse A33 antigen, a definitive marker for basolateral surfaces of intestinal epithelial cells

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4631784

Immunohistochemical expression of MMP-7 protein and its serum level in colorectal cancer.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4631784

WNT-pathway activation in IBD-associated colorectal carcinogenesis: potential biomarkers for colonic surveillance.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4631784

Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4631784

Elevated Dnmt3a activity promotes polyposis in Apc(Min) mice by relaxing extracellular restraints on Wnt signaling

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4631784

Paneth cell differentiation in colonic epithelial neoplasms: evidence for the role of the Apc/beta-catenin/Tcf pathway

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4631784

Colon cancer--understanding how NSAIDs work

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4631784

Molecular determinants of dysplasia in colorectal lesions.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4631784

Intestinal dysplasia and adenoma in transgenic mice after overexpression of an activated beta-catenin

22 September 2018

1 reference

12 December 2020

1 reference

12 December 2020

Loss of Apc in intestinal adenomas from Min mice

1 reference

12 December 2020

Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability

1 reference

12 December 2020

Clinical significance of large tenascin-C spliced variant as a potential biomarker for colorectal cancer

1 reference

12 December 2020

Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons

1 reference

12 December 2020

Axis induction by wnt signaling: Target promoter responsiveness regulates competence

1 reference

12 December 2020

Identifiers

DOI

10.1242/DMM.019844

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26398937 AND SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26398937 AND SRC:MED&resulttype=core&format=json

3 June 2020

PubMed publication ID

26398937

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26398937 AND SRC:MED&resulttype=core&format=json