Janus Compounds, 5-Chloro-N⁴-methyl-N⁴-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects. (Q36213315)

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English	Janus Compounds, 5-Chloro-N⁴-methyl-N⁴-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects.	scientific article

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29 March 2020

Janus Compounds, 5-Chloro-N⁴-methyl-N⁴-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects (English)

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29 March 2020

April L Risinger

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29 March 2020

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Cristina C Rohena

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29 March 2020

Ravi Kumar Vyas Devambatla

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29 March 2020

Nicholas F Dybdal-Hargreaves

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29 March 2020

Roma Kaul

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29 March 2020

Shruti Choudhary

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29 March 2020

Aleem Gangjee

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29 March 2020

Susan L Mooberry

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29 March 2020

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29 March 2020

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2 December 2016

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0 references

Microtubule destabilising agents: far more than just antimitotic anticancer drugs

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29 June 2018

Recent advances of cytotoxic chalconoids targeting tubulin polymerization: Synthesis and biological activity.

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29 June 2018

Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells

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29 June 2018

Recent Advances in Heterocyclic Tubulin Inhibitors Targeting the Colchicine Binding Site

1 reference

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29 June 2018

Microtubule-stabilizing agents: New drug discovery and cancer therapy

1 reference

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Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design

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The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.

1 reference

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Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins

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29 June 2018

The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents

1 reference

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Microtubule-targeting agents are clinically successful due to both mitotic and interphase impairment of microtubule function

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The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization

1 reference

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29 June 2018

Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities

1 reference

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29 June 2018

Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents

1 reference

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Intravital FRET imaging of tumor cell viability and mitosis during chemotherapy

1 reference

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29 June 2018

Synthesis of N(4)-(substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470396

29 June 2018

An overview of tubulin inhibitors that interact with the colchicine binding site

1 reference

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29 June 2018

Novel water-soluble substituted pyrrolo[3,2-d]pyrimidines: design, synthesis, and biological evaluation as antitubulin antitumor agents

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Inhibitors targeting mitosis: tales of how great drugs against a promising target were brought down by a flawed rationale

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Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer

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Synthesis and biological activities of (R)- and (S)-N-(4-Methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride as potent cytotoxic antitubulin agents

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Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance

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Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents

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12 December 2020

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