Isocitrate dehydrogenase 1 R132C mutation occurs exclusively in microsatellite stable colorectal cancers with the CpG island methylator phenotype (Q36213070)

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English	Isocitrate dehydrogenase 1 R132C mutation occurs exclusively in microsatellite stable colorectal cancers with the CpG island methylator phenotype	scientific article

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24 February 2020

Isocitrate dehydrogenase 1 R132C mutation occurs exclusively in microsatellite stable colorectal cancers with the CpG island methylator phenotype (English)

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24 February 2020

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Grant W. Montgomery

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24 February 2020

Leesa F. Wockner

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24 February 2020

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V L J Whitehall

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T D Dumenil

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D M McKeone

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C E Bond

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M L Bettington

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R L Buttenshaw

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L Bowdler

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B A Leggett

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1 November 2014

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24 February 2020

1454-1460

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24 February 2020

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Focus on genetic and epigenetic events of colorectal cancer pathogenesis: implications for molecular diagnosis

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CpG island methylator phenotype is associated with response to adjuvant irinotecan-based therapy for stage III colon cancer.

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1 October 2017

Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators.

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1 October 2017

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1 October 2017

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1 October 2017

Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation.

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1 October 2017

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1 October 2017

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1 October 2017

Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients

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1 October 2017

IDH mutation impairs histone demethylation and results in a block to cell differentiation

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1 October 2017

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

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Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production

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1 October 2017

Genome-scale analysis of aberrant DNA methylation in colorectal cancer

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1 October 2017

IDH1 and IDH2 mutations in pediatric acute leukemia

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1 October 2017

Body size, physical activity and risk of colorectal cancer with or without the CpG island methylator phenotype (CIMP).

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1 October 2017

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

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1 October 2017

Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis

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1 October 2017

Alcohol consumption and rectal tumor mutations and epigenetic changes

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1 October 2017

Cigarette smoking and colorectal cancer risk by molecularly defined subtypes

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Role of the serrated pathway in colorectal cancer pathogenesis

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1 October 2017

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1 October 2017

Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor

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1 October 2017

The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622530

1 October 2017

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

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1 October 2017

IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group

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1 October 2017

Three DNA methylation epigenotypes in human colorectal cancer

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1 October 2017

IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25496513

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.4161/15592294.2014.971624

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25496513 AND SRC:MED&resulttype=core&format=json

24 February 2020

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Europe PubMed Central

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24 February 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25496513 AND SRC:MED&resulttype=core&format=json

24 February 2020

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