Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice (Q36206696)

12 August 2017

Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice (English)

1 reference

12 August 2017

Nga Bien-Ly

1

1 reference

12 August 2017

Anna K Gillespie

2

1 reference

12 August 2017

David Walker

3

1 reference

12 August 2017

Seo Yeon Yoon

4

1 reference

12 August 2017

Yadong Huang

5

1 reference

12 August 2017

language of work or name

English

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publication date

1 April 2012

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12 August 2017

Journal of Neuroscience

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12 August 2017

32

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12 August 2017

14

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12 August 2017

4803-4811

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describes a project that uses

12 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3433173/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

1 October 2017

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C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-β (Aβ) and acts in concert with Aβ to elicit neuronal and behavioral deficits in mice

1 October 2017

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Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain

1 October 2017

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Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice

1 October 2017

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ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice

1 October 2017

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Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease

1 October 2017

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Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice

1 October 2017

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The role of apolipoprotein E in Alzheimer's disease

1 October 2017

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Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

1 October 2017

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ApoE promotes the proteolytic degradation of Abeta

1 October 2017

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Molecular and cellular mechanisms of apolipoprotein E4 neurotoxicity and potential therapeutic strategies.

1 October 2017

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Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease

1 October 2017

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Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease

1 October 2017

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 October 2017

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Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

1 October 2017

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Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

1 October 2017

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 October 2017

1 reference

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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

1 October 2017

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Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

1 October 2017

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 October 2017

1 reference

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Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

1 October 2017

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Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

1 October 2017

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Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E.

1 October 2017

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Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

2 July 2018

1 reference

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Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging.

2 July 2018

1 reference

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Reduced levels of human apoE4 protein in an animal model of cognitive impairment

22 September 2018

1 reference

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Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.

22 September 2018

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Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism.

22 September 2018

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Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels

22 September 2018

1 reference

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Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.

22 September 2018

1 reference

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Effect of domain interaction on apolipoprotein E levels in mouse brain.

22 September 2018

1 reference

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Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433173

Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease

22 September 2018

1 reference

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Apolipoprotein E and beta-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433173

Lack of allelic imbalance in APOE epsilon3/4 brain mRNA expression in Alzheimer's disease

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433173

Distortion of allelic expression of apolipoprotein E in Alzheimer's disease.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433173

Apolipoprotein E (apoE) levels in brains from Alzheimer disease patients and controls.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433173

Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433173

Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433173

Brain expression of apolipoproteins E, J, and A-I in Alzheimer's disease

5 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22492035

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1523/JNEUROSCI.0033-12.2012

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

22492035

1 reference