Using Drosophila melanogaster to map human cancer pathways (Q36202195)

12 August 2017

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title

Using Drosophila melanogaster to map human cancer pathways (English)

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12 August 2017

main subject

Drosophila melanogaster

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Helena E Richardson

2

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author name string

Anthony M Brumby

series ordinal

1

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12 August 2017

language of work or name

English

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publication date

1 August 2005

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12 August 2017

published in

Nature Reviews Cancer

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12 August 2017

volume

5

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12 August 2017

issue

8

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12 August 2017

page(s)

626-639

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12 August 2017

cites work

The Hallmarks of Cancer

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Creation of human tumour cells with defined genetic elements

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Enumeration of the simian virus 40 early region elements necessary for human cell transformation

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Putting tumours in context

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Cancer: dangerous liaisons

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Cancer modeling in the modern era: progress and challenges

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Drosophila, the golden bug, emerges as a tool for human genetics

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Understanding Human Cancer in a Fly?

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A survey of human disease gene counterparts in the Drosophila genome

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The proliferation of Drosophila in cancer research: a system for the functional characterization of tumor suppressors and oncogenes

21 January 2018

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Drosophila in cancer research. An expanding role.

21 January 2018

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A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila.

21 January 2018

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Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

21 January 2018

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The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

21 January 2018

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scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila

21 January 2018

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Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye.

21 January 2018

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Control of cell proliferation in the Drosophila eye by Notch signaling.

21 January 2018

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Notch activity in neural cells triggered by a mutant allele with altered glycosylation.

21 January 2018

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Apical accumulation of the Drosophila PDGF/VEGF receptor ligands provides a mechanism for triggering localized actin polymerization

21 January 2018

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decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary

21 January 2018

1 reference

Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue

21 January 2018

1 reference

Dpp Signaling Silences bam Transcription Directly to Establish Asymmetric Divisions of Germline Stem Cells

21 January 2018

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A directed screen for genes involved in Drosophila blood cell activation

21 January 2018

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Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors

21 January 2018

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Mutations in the beta-propeller domain of the Drosophila brain tumor (brat) protein induce neoplasm in the larval brain

21 January 2018

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A temperature-sensitive brain tumor suppressor mutation of Drosophila melanogaster: developmental studies and molecular localization of the gene

21 January 2018

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Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death

21 January 2018

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Drosophila p53 preserves genomic stability by regulating cell death

21 January 2018

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Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions

21 January 2018

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Coordination of growth and cell division in the Drosophila wing

21 January 2018

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A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis

21 January 2018

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Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development.

21 January 2018

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Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E.

21 January 2018

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Growth and differentiation in the Drosophila eye coordinated by hedgehog

21 January 2018

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Temporal control of differentiation by the insulin receptor/tor pathway in Drosophila

21 January 2018

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bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila

21 January 2018

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The Drosophila cyclin D-Cdk4 complex promotes cellular growth

21 January 2018

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Drosophila myc regulates cellular growth during development.

21 January 2018

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Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing

21 January 2018

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Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development.

21 January 2018

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The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling

21 January 2018

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Ras promotes cell survival in Drosophila by downregulating hid expression

21 January 2018

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Methyl jasmonate induces traumatic resin ducts, terpenoid resin biosynthesis, and terpenoid accumulation in developing xylem of Norway spruce stems

21 January 2018

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Coupling cell growth, proliferation, and death. Hippo weighs in.

21 January 2018

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The Drosophila F box protein archipelago regulates dMyc protein levels in vivo

21 January 2018

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A role for wingless in an early pupal cell death event that contributes to patterning the Drosophila eye.

21 January 2018

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Integrin-dependent apposition of Drosophila extraembryonic membranes promotes morphogenesis and prevents anoikis.

21 January 2018

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Mechanisms for removal of developmentally abnormal cells: cell competition and morphogenetic apoptosis

21 January 2018

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Drosophila myc regulates organ size by inducing cell competition

21 January 2018

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dMyc transforms cells into super-competitors

21 January 2018

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Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development.

21 January 2018

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Localized Notch signal acts through eyg and upd to promote global growth in Drosophila eye.

21 January 2018

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Long-range effect of upd, a ligand for Jak/STAT pathway, on cell cycle in Drosophila eye development

21 January 2018

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The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms

21 January 2018

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Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role

21 January 2018

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Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways.

21 January 2018

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Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila.

21 January 2018

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Mechanisms of cancer cell invasion

21 January 2018

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Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells

21 January 2018

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A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptor

21 January 2018

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The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival

21 January 2018

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Involvement of chemokine receptors in breast cancer metastasis

21 January 2018

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Myosin VI is required for E-cadherin-mediated border cell migration

21 January 2018

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Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer

21 January 2018

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Regulation of invasive cell behavior by taiman, a Drosophila protein related to AIB1, a steroid receptor coactivator amplified in breast cancer

21 January 2018

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AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer

21 January 2018

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Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila

21 January 2018

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The Jak/STAT pathway in model organisms: emerging roles in cell movement

21 January 2018

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Epithelial-mesenchymal transitions in tumour progression

21 January 2018

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The role of DE-cadherin during cellularization, germ layer formation and early neurogenesis in the Drosophila embryo

21 January 2018

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Epithelial cell polarity and cell junctions in Drosophila

21 January 2018

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Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity

21 January 2018

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The Drosophila Sterile-20 Kinase Slik Controls Cell Proliferation and Apoptosis during Imaginal Disc Development

21 January 2018

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Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growth

21 January 2018

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The Rho GTPase and a Putative RhoGEF Mediate a Signaling Pathway for the Cell Shape Changes in Drosophila Gastrulation

21 January 2018

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The epithelial-mesenchymal transition of the Drosophila mesoderm requires the Rho GTP exchange factor Pebble

21 January 2018

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The RhoGEF Pebble is required for cell shape changes during cell migration triggered by the Drosophila FGF receptor Heartless.

21 January 2018

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Rho GTPases in transformation and metastasis.

21 January 2018

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NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

21 January 2018

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Rac promotes epithelial cell rearrangement during tracheal tubulogenesis in Drosophila.

21 January 2018

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Localization of apical epithelial determinants by the basolateral PDZ protein Scribble

21 January 2018

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Neoplastic Transformation and Aberrant Cell–Cell Interactions in Genetic Mosaics oflethal(2)giant larvae (lgl),a Tumor Suppressor Gene ofDrosophila

21 January 2018

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Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes

21 January 2018

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A Genetic Screen in Drosophila for Metastatic Behavior

21 January 2018

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Integrated activity of PDZ protein complexes regulates epithelial polarity

21 January 2018

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Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization.

21 January 2018

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Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble

21 January 2018

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Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin

21 January 2018

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Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses

21 January 2018

1 reference

Understanding human cancer using Drosophila: Tid47, a cytosolic product of the DnaJ-like tumor suppressor gene l2Tid, is a novel molecular partner of patched related to skin cancer

21 January 2018

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Developmental control of blood cell migration by the Drosophila VEGF pathway

21 January 2018

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Guidance of cell migration by the Drosophila PDGF/VEGF receptor

21 January 2018

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Segregation of receptor and ligand regulates activation of epithelial growth factor receptor

21 January 2018

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Drosophila screening model for metastasis: Semaphorin 5c is required for l(2)gl cancer phenotype

21 January 2018

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The control of cell motility and epithelial morphogenesis by Jun kinases

21 January 2018

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Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epithelia

21 January 2018

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Role of Rho-family proteins in cell adhesion and cancer.

21 January 2018

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Genetic mosaic techniques for studying Drosophila development.

21 January 2018

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Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions

21 January 2018

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Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development

21 January 2018

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Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways.

21 January 2018

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Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis

21 January 2018

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Cell proliferation, survival, and death in the Drosophila eye.

21 January 2018

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Germ cell specification and migration in Drosophila and beyond

21 January 2018

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Cell movements during gastrulation: snail dependent and independent pathways

21 January 2018

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The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

21 January 2018

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Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis

21 January 2018

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Border-cell migration: the race is on.

21 January 2018

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Ovarian cancer metastasis: integrating insights from disparate model organisms

21 January 2018

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Signal transduction by the JNK group of MAP kinases

21 January 2018

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TGF-beta signaling in cancer--a double-edged sword

21 January 2018

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Parallels between tissue repair and embryo morphogenesis

21 January 2018

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Genetic control of cell intercalation during tracheal morphogenesis in Drosophila

21 January 2018

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Branching morphogenesis of the Drosophila tracheal system.

21 January 2018

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Cell polarity: the ups and downs of the Par6/aPKC complex

21 January 2018

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The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl.

21 January 2018

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Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast

21 January 2018

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Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells

21 January 2018

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Fragile X protein functions with lgl and the par complex in flies and mice

21 January 2018

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Mammalian Scribble forms a tight complex with the betaPIX exchange factor

21 January 2018

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Distribution of Glut1 in detergent-resistant membranes (DRMs) and non-DRM domains: effect of treatment with azide

21 January 2018

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Genetic, cytogenetic and developmental analysis of the Drosophila melanogaster tumor suppressor gene lethal(2)tumorous imaginal discs (1(2)tid)

21 January 2018

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RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila

31 March 2020

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Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs

31 March 2020

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E2F-induced S phase requires cyclin E.

31 March 2020

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Role of DE-Cadherin in Neuroblast Proliferation, Neural Morphogenesis, and Axon Tract Formation inDrosophilaLarval Brain Development

31 March 2020

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DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila

31 March 2020

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Inhibition of patterned cell shape change and cell invasion by Discs large during Drosophila oogenesis

31 March 2020

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The genetics and epigenetics of neoplasms in Drosophila

31 March 2020

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Organizing a functional junctional complex requires specific domains of the Drosophila MAGUK Discs large

31 March 2020

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DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila.

31 March 2020

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The yeast par-1 homologs kin1 and kin2 show genetic and physical interactions with components of the exocytic machinery

31 March 2020

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Composition and function of PDZ protein complexes during cell polarization

31 March 2020

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Ras pathway signals are required for notch-mediated oncogenesis

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1671

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12 August 2017

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