PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis (Q36199783)

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11 February 2020

title

PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis (English)

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11 February 2020

0 references

1

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11 February 2020

David H Hawke

3

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11 February 2020

author name string

Yan Xia

2

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11 February 2020

Xinjian Li

4

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11 February 2020

Ji Liang

5

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11 February 2020

Dongming Xing

6

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11 February 2020

Kenneth Aldape

7

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11 February 2020

Tony Hunter

8

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11 February 2020

W K Alfred Yung

9

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11 February 2020

Zhimin Lu

10

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11 February 2020

language of work or name

English

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publication date

1 August 2012

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11 February 2020

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volume

150

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issue

4

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page(s)

685-696

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Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

11 February 2020

cites work

1 reference

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Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

1 October 2017

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Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

1 October 2017

1 reference

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When Signaling Kinases Meet Histones and Histone Modifiers in the Nucleus

1 October 2017

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1 October 2017

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1 October 2017

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The Language of Histone Crosstalk

1 October 2017

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1 October 2017

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H3 phosphorylation: dual role in mitosis and interphase

1 October 2017

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1 October 2017

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Crosstalk among Histone Modifications

1 October 2017

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1 October 2017

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

1 October 2017

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

1 October 2017

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Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression

1 October 2017

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Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

1 October 2017

1 reference

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Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation

1 October 2017

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Malignant astrocytic glioma: genetics, biology, and paths to treatment

1 October 2017

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Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase.

1 October 2017

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Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death

1 October 2017

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Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity

1 October 2017

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c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis

1 October 2017

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Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis

1 October 2017

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Pyruvate kinase type M2 and its role in tumor growth and spreading

1 October 2017

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Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase

1 October 2017

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1 October 2017

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1 October 2017

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1 October 2017

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1 October 2017

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1 October 2017

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1 October 2017

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2 July 2018

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2 July 2018

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22 September 2018

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Delta-24 increases the expression and activity of topoisomerase I and enhances the antiglioma effect of irinotecan

22 September 2018

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Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes

22 September 2018

1 reference

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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

22 September 2018

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Wnt-independent beta-catenin transactivation in tumor development.

22 September 2018

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Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion.

22 September 2018

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Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22901803

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pyruvate kinase type M2: a key regulator within the tumour metabolome and a tool for metabolic profiling of tumours

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22901803

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2012.07.018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22901803 AND SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22901803 AND SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

22901803

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22901803 AND SRC:MED&resulttype=core&format=json