Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network (Q36184401)

12 August 2017

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title

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network (English)

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12 August 2017

2

Edward J Goetzl

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12 August 2017

Hugh Rosen

1

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12 August 2017

publication date

1 July 2005

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Nature Reviews Immunology

12 August 2017

published in

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12 August 2017

volume

5

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12 August 2017

issue

7

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12 August 2017

page(s)

560-570

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Signaling and biological actions of sphingosine 1-phosphate

12 August 2017

cites work

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The emerging role of lysophosphatidic acid in cancer

31 March 2020

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Lysophospholipid G protein-coupled receptors

31 March 2020

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Thrombogenic and atherogenic activities of lysophosphatidic acid

31 March 2020

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Mechanisms of cardioprotection by lysophospholipids

31 March 2020

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The bioactive phospholipid lysophosphatidic acid is released from activated platelets.

31 March 2020

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Sphingolipid metabolites: members of a new class of lipid second messengers

31 March 2020

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Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

31 March 2020

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Generation and metabolism of bioactive sphingosine-1-phosphate

31 March 2020

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Lysophospholipids and their G protein-coupled receptors in biology and diseases

31 March 2020

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Functional characterization of human sphingosine kinase-1

31 March 2020

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Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response.

31 March 2020

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Lipid phosphate phosphatases regulate signal transduction through glycerolipids and sphingolipids

31 March 2020

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Sphingolipids and the balancing of immune cell function: lessons from the mast cell

31 March 2020

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Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin

31 March 2020

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Sphingosine kinase 1 is an intracellular effector of phosphatidic acid

31 March 2020

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Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor

31 March 2020

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Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis

31 March 2020

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Sphingosine kinase: a mediator of vital cellular functions

31 March 2020

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Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis

31 March 2020

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Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory system

31 March 2020

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Cutting edge: differential constitutive expression of functional receptors for lysophosphatidic acid by human blood lymphocytes

31 March 2020

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Altered expression and functional profile of lysophosphatidic acid receptors in mitogen-activated human blood T lymphocytes

31 March 2020

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Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist

31 March 2020

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Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration

31 March 2020

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Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes

31 March 2020

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Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit

31 March 2020

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Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells

31 March 2020

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Physiological sphingosine 1-phosphate requirement for optimal activity of mouse CD4 regulatory T Cells

31 March 2020

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Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.

31 March 2020

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The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor

31 March 2020

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Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses

31 March 2020

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Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases

31 March 2020

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Human eosinophil chemotaxis and selective in vivo recruitment by sphingosine 1-phosphate.

31 March 2020

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Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate

31 March 2020

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Transduction of Multiple Effects of Sphingosine 1-Phosphate (S1P) on T Cell Functions by the S1P1 G Protein-Coupled Receptor

31 March 2020

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Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.

31 March 2020

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A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors

31 March 2020

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Molecular basis for lysophosphatidic acid receptor antagonist selectivity

31 March 2020

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Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.

31 March 2020

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Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate

31 March 2020

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Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.

31 March 2020

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Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines

31 March 2020

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The role of post-translational modifications of the CXCR4 amino terminus in stromal-derived factor 1 alpha association and HIV-1 entry

31 March 2020

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Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines

31 March 2020

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A family of receptors coupled to guanine nucleotide regulatory proteins

31 March 2020

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Lysophospholipid receptors: signaling and biology

31 March 2020

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Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury

31 March 2020

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Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury

31 March 2020

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In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights

31 March 2020

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The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches.

31 March 2020

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Type 4 sphingosine 1-phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration

31 March 2020

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The role of sphingosine kinase in the signaling initiated at the high-affinity receptor for IgE (FcepsilonRI) in mast cells

31 March 2020

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The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggering

31 March 2020

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Lysophosphatidic acid accelerates the development of human mast cells

31 March 2020

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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

31 March 2020

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The sphingosine-1-phosphate (S1P) lysophospholipid receptor S1P3 regulates MAdCAM-1 endothelial cells in splenic marginal sinus organization

31 March 2020

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S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate

31 March 2020

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Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes

31 March 2020

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Cutting edge: regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1.

31 March 2020

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Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

31 March 2020

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G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation.

31 March 2020

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Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3.

31 March 2020

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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

31 March 2020

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Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

31 March 2020

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Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.

31 March 2020

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FTY720, a novel immunosuppressant, induces sequestration of circulating lymphocytes by acceleration of lymphocyte homing

31 March 2020

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Potent immunosuppressants, 2-alkyl-2-aminopropane-1,3-diols

31 March 2020

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FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory

31 March 2020

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Antigen-specific lymphocyte sequestration in lymphoid organs: lack of essential roles for alphaL and alpha4 integrin-dependent adhesion or Galphai protein-coupled receptor signaling

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1650

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Dimensions Publication ID

12 August 2017

1050982544

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