Weekly Treatment of 2-Hydroxypropyl-β-cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice (Q36184055)

12 August 2017

Weekly Treatment of 2-Hydroxypropyl-β-cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice (English)

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12 August 2017

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2

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3 June 2020

Mike Jeurissen

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Patrick J van Gorp

5

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3 June 2020

Nathalie Vaes

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3 June 2020

Ronit Shiri-Sverdlov

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Steven W M Olde Damink

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3 June 2020

author name string

Sofie M A Walenbergh

1

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Tim Hendrikx

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3 June 2020

Fons Verheyen

8

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3 June 2020

Ger H Koek

9

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Dieter Lütjohann

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Alena Grebe

11

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Eicke Latz

12

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3 June 2020

language of work or name

English

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publication date

2 September 2015

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International Journal of Molecular Sciences

12 August 2017

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3 June 2020

volume

16

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issue

9

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3 June 2020

page(s)

21056-21069

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Creative Commons Attribution 4.0 International

3 June 2020

copyright license

start time

2 September 2015

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Systemic administration of 2-hydroxypropyl-β-cyclodextrin to symptomatic Npc1-deficient mice slows cholesterol sequestration in the major organs and improves liver function

1 October 2017

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1 October 2017

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1 October 2017

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Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation

1 October 2017

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Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis

1 October 2017

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Cyclodextrin mediates rapid changes in lipid balance in Npc1-/- mice without carrying cholesterol through the bloodstream.

1 October 2017

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Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells

1 October 2017

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Specific immunization strategies against oxidized low-density lipoprotein: a novel way to reduce nonalcoholic steatohepatitis in mice

1 October 2017

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LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease

1 October 2017

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Normalization of Cholesterol Homeostasis by 2-Hydroxypropyl-β-cyclodextrin in Neurons and Glia from Niemann-Pick C1 (NPC1)-deficient Mice

1 October 2017

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Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations

1 October 2017

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1 October 2017

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Niemann-Pick disease type C

1 October 2017

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Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection

1 October 2017

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

1 October 2017

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Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells

1 October 2017

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Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice.

1 October 2017

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Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid

1 October 2017

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Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells

1 October 2017

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Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression

1 October 2017

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Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse

1 October 2017

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Endolysosomal phospholipidosis and cytosolic lipid droplet storage and release in macrophages

1 October 2017

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1 October 2017

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Plasma levels of plant sterols and the risk of coronary artery disease: the prospective EPIC-Norfolk Population Study

1 October 2017

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Advanced atherosclerotic foam cell formation has features of an acquired lysosomal storage disorder

1 October 2017

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Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages

1 October 2017

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High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs.

1 October 2017

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Nonalcoholic fatty liver disease

1 October 2017

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Lysosomal cholesterol derived from mildly oxidized low density lipoprotein is resistant to efflux

1 October 2017

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Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery

1 October 2017

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Weekly cyclodextrin administration normalizes cholesterol metabolism in nearly every organ of the Niemann-Pick type C1 mouse and markedly prolongs life.

1 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613241

Formation of cholesterol monohydrate crystals in macrophage-derived foam cells.

2 July 2018

1 reference

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Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages

2 July 2018

1 reference

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The Cholesterol Derivative 27-Hydroxycholesterol Reduces Steatohepatitis in Mice

2 July 2018

1 reference

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Phytosterol-enriched yogurt increases LDL affinity and reduces CD36 expression in polygenic hypercholesterolemia

23 September 2018

1 reference

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Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis

23 September 2018

1 reference

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Plasma markers of cholesterol homeostasis and apolipoprotein B-100 kinetics in the metabolic syndrome.

23 September 2018

1 reference

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Introducing a new component of the metabolic syndrome: low cholesterol absorption.

23 September 2018

1 reference

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Lysosomal lipid accumulation from oxidized low density lipoprotein is correlated with hypertrophy of the Golgi apparatus and trans-Golgi network.

23 September 2018

1 reference

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23 September 2018

Identifiers

DOI

10.3390/IJMS160921056

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26404254 AND SRC:MED&resulttype=core&format=json

release_ci6hzt5yijgh3bjzhfeejfqwva

3 June 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ci6hzt5yijgh3bjzhfeejfqwva

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26404254 AND SRC:MED&resulttype=core&format=json

3 June 2020

PubMed publication ID

26404254

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26404254 AND SRC:MED&resulttype=core&format=json