A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma. (Q36182645)

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2 February 2020

title

A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma (English)

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4

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Roch-Philippe Charles

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Wayne A. Phillips

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Joe W Gray

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Laura M Heiser

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Eric A Collisson

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2 February 2020

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Paul T Spellman

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2 February 2020

author name string

Christy L Trejo

2

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2 February 2020

Jillian M Silva

3

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2 February 2020

James E Korkola

5

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2 February 2020

Brian A Rabinovich

8

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2 February 2020

Byron Hann

9

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David Dankort

10

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Martin McMahon

14

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publication date

24 May 2012

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2 February 2020

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2 February 2020

volume

2

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issue

8

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2 February 2020

page(s)

685-693

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Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

2 February 2020

cites work

1 reference

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An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

1 October 2017

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C-Raf is required for the initiation of lung cancer by K-Ras(G12D).

1 October 2017

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Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers

1 October 2017

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Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

1 October 2017

1 reference

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Combination Treatment with MEK and AKT Inhibitors Is More Effective than Each Drug Alone in Human Non-Small Cell Lung Cancer In Vitro and In Vivo

1 October 2017

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

1 October 2017

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Ras signaling and therapies

1 October 2017

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

1 October 2017

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Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

1 October 2017

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Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia

1 October 2017

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

1 October 2017

1 reference

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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

1 October 2017

1 reference

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Stabilization of beta-catenin induces pancreas tumor formation

1 October 2017

1 reference

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A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors

1 October 2017

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Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

1 October 2017

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Genetics and biology of pancreatic ductal adenocarcinoma.

1 October 2017

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Pharmacologic inhibition of RAF-->MEK-->ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1.

1 October 2017

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

1 October 2017

1 reference

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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

1 October 2017

1 reference

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Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis

1 October 2017

1 reference

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Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1 October 2017

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Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models

1 October 2017

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Raf-1 addiction in Ras-induced skin carcinogenesis

23 September 2018

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Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22628411

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/2159-8290.CD-11-0347

1 reference

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2 February 2020

1 reference

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2 February 2020

PubMed publication ID

22628411

1 reference

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