Targeting AMPK: From Ancient Drugs to New Small-Molecule Activators (Q36182575)

12 August 2017

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title

Targeting AMPK: From Ancient Drugs to New Small-Molecule Activators (English)

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12 August 2017

2

Benoit Viollet

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12 August 2017

Bruno Guigas

1

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publication date

1 January 2016

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12 August 2017

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12 August 2017

volume

107

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12 August 2017

page(s)

327-350

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Microarrayed compound screening (microARCS) to identify activators and inhibitors of AMP-activated protein kinase

12 August 2017

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Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug

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Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), etc.

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Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

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Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer

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Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

21 January 2018

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Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

21 January 2018

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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

21 January 2018

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Metformin: from mechanisms of action to therapies

21 January 2018

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Immunometabolism of AMPK in insulin resistance and atherosclerosis

21 January 2018

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Salicylate improves macrophage cholesterol homeostasis via activation of Ampk.

21 January 2018

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Direct AMP-activated protein kinase activators: a review of evidence from the patent literature

21 January 2018

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A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis

21 January 2018

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Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

21 January 2018

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AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation

21 January 2018

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AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside

21 January 2018

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Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators

21 January 2018

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AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels

21 January 2018

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AMPK--sensing energy while talking to other signaling pathways

21 January 2018

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AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

21 January 2018

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Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

21 January 2018

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The ancient drug salicylate directly activates AMP-activated protein kinase

21 January 2018

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The early clinical history of salicylates in rheumatology and pain

21 January 2018

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Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity

21 January 2018

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Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.

21 January 2018

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Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK

21 January 2018

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AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes

21 January 2018

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PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

21 January 2018

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HL156A, a novel AMP-activated protein kinase activator, is protective against peritoneal fibrosis in an in vivo and in vitro model of peritoneal fibrosis.

21 January 2018

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A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.

21 January 2018

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Screening methods for AMP-activated protein kinase modulators: a patent review

21 January 2018

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AMPK beta subunits display isoform specific affinities for carbohydrates

21 January 2018

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The molecular targets of resveratrol

21 January 2018

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A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators.

21 January 2018

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Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry

21 January 2018

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Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

21 January 2018

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Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice.

21 January 2018

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Structural basis of AMPK regulation by adenine nucleotides and glycogen.

21 January 2018

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Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance.

21 January 2018

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Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK

21 January 2018

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Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK.

21 January 2018

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Antiplatelet effect of a newly developed AMP-activated protein kinase activator YLF-466D.

21 January 2018

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The role of AMPK in controlling metabolism and mitochondrial biogenesis during exercise

21 January 2018

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The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice.

21 January 2018

1 reference

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Pharmacological Targeting of AMP-Activated Protein Kinase and Opportunities for Computer-Aided Drug Design

21 January 2018

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Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-43589-3_13

Metformin in cancer treatment and prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-43589-3_13

A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism

21 January 2018

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Expanding roles for AMPK in skeletal muscle plasticity

21 January 2018

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Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis.

21 January 2018

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https://api.crossref.org/works/10.1007/978-3-319-43589-3_13

Metabolism of inflammation limited by AMPK and pseudo-starvation

21 January 2018

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β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

21 January 2018

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AMPK is a direct adenylate charge-regulated protein kinase.

21 January 2018

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AMPK functions as an adenylate charge-regulated protein kinase.

21 January 2018

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The recruitment of AMP-activated protein kinase to glycogen is regulated by autophosphorylation

21 January 2018

1 reference

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Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells

21 January 2018

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Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase

21 January 2018

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Structural basis for glycogen recognition by AMP-activated protein kinase

21 January 2018

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https://api.crossref.org/works/10.1007/978-3-319-43589-3_13

AMPK: energy sensor and survival mechanism in the ischemic heart

21 January 2018

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Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

21 January 2018

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Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases

21 January 2018

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AMPK-dependent and independent effects of AICAR and compound C on T-cell responses

21 January 2018

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Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms

21 January 2018

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AMPK, insulin resistance, and the metabolic syndrome

21 January 2018

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AMP-activated protein kinase: a potential player in Alzheimer's disease

21 January 2018

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Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

21 January 2018

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Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

21 January 2018

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Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

21 January 2018

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Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.

21 January 2018

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Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release.

21 January 2018

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Past strategies and future directions for identifying AMP-activated protein kinase (AMPK) modulators

21 January 2018

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AMPK in Health and Disease

21 January 2018

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Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

21 January 2018

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A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake

21 January 2018

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Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

21 January 2018

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A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.

21 January 2018

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Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action

21 January 2018

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AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

21 January 2018

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Salsalate activates brown adipose tissue in mice

21 January 2018

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Differential effects of AMPK agonists on cell growth and metabolism

21 January 2018

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AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.

21 January 2018

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Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation.

21 January 2018

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Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders

21 January 2018

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AMP-activated protein kinase, stress responses and cardiovascular diseases

21 January 2018

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Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1.

21 January 2018

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The blooming of the French lilac

21 January 2018

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Chemoproteomic analysis of intertissue and interspecies isoform diversity of AMP-activated protein kinase (AMPK).

21 January 2018

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Structural basis for AMP binding to mammalian AMP-activated protein kinase

21 January 2018

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Structure of mammalian AMPK and its regulation by ADP

21 January 2018

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Resveratrol prevents hyperglycemia-induced endothelial dysfunction via activation of adenosine monophosphate-activated protein kinase

21 January 2018

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SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling

21 January 2018

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Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

21 January 2018

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AMP-activated protein kinase modulators: a patent review (2006 – 2010)

21 January 2018

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https://api.crossref.org/works/10.1007/978-3-319-43589-3_13

A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

21 January 2018

1 reference

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Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicals

21 January 2018

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Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

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Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species

21 January 2018

1 reference

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5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase Translocation

21 January 2018

1 reference

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Predominant alpha2/beta2/gamma3 AMPK activation during exercise in human skeletal muscle

21 January 2018

1 reference

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Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase

31 March 2020

1 reference

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Apoptotic effects of extract from Cnidium monnieri (L.) Cusson by adenosine monosphosphate-activated protein kinase-independent pathway in HCT116 colon cancer cells

31 March 2020

1 reference

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Characterisation of 5'-AMP-activated protein kinase in human liver using specific peptide substrates and the effects of 5'-AMP analogues on enzyme activity

31 March 2020

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Bypassing AMPK Phosphorylation

31 March 2020

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Structural basis of AMPK regulation by small molecule activators

31 March 2020

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10.1007/978-3-319-43589-3_13

31 March 2020

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