Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening (Q36179596)

12 August 2017

Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening (English)

1 reference

12 August 2017

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5

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8 June 2020

author name string

L-J Liu

1

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8 June 2020

K-H Leung

2

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8 June 2020

D S-H Chan

3

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8 June 2020

Y-T Wang

4

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8 June 2020

C-H Leung

6

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8 June 2020

publication date

12 June 2014

1 reference

12 August 2017

Cell Death and Disease

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8 June 2020

volume

5

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8 June 2020

page(s)

e1293

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

8 June 2020

copyright license

start time

1 June 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells

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The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines

1 October 2017

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1 October 2017

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Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice

1 October 2017

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Chemosensitization of tumors by resveratrol

1 October 2017

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1 October 2017

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Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

1 October 2017

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A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy

1 October 2017

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Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic cancer cell lines and downregulation of survivin/BIRC5 gene expression

1 October 2017

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A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes

1 October 2017

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STATs in cancer inflammation and immunity: a leading role for STAT3

1 October 2017

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Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.

1 October 2017

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STAT3 in CD4 T helper cell differentiation and inflammatory diseases

1 October 2017

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Synthesis, discovery and preliminary SAR study of benzofuran derivatives as angiogenesis inhibitors

1 October 2017

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Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells

1 October 2017

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Resveratrol addiction: to die or not to die.

1 October 2017

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LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3-mediated matrix metalloproteinase 9 expression

1 October 2017

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SOCS regulation of the JAK/STAT signalling pathway

1 October 2017

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Paradigm shifts in the cell biology of STAT signaling

1 October 2017

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Ups and downs: the STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling.

1 October 2017

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Inhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotides.

1 October 2017

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Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

1 October 2017

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The JAK-STAT signaling pathway: input and output integration

1 October 2017

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STAT3 as a central mediator of neoplastic cellular transformation

1 October 2017

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STAT3: a multifaceted oncogene

1 October 2017

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Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor

1 October 2017

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Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer

1 October 2017

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STAT3 as a therapeutic target in head and neck cancer

1 October 2017

1 reference

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STAT3 in immune responses and inflammatory bowel diseases

1 October 2017

1 reference

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Regulation of cytokine signaling pathways by PIAS proteins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Synthesis and evaluation of 3-methyl-4-oxo-6-phenyl-4,5,6,7-tetrahydrobenzofuran-2-carboxylic acid ethyl ester derivatives as potent antitumor agents

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Inhibitors of cytokine signal transduction

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Prediction of the binding energy for small molecules, peptides and proteins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Three-dimensional structure of the Stat3beta homodimer bound to DNA

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Biased probability Monte Carlo conformational searches and electrostatic calculations for peptides and proteins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Stat3 and Stat4: members of the family of signal transducers and activators of transcription

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Structure-based discovery of natural-product-like TNF-α inhibitors

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Flexible protein–ligand docking by global energy optimization in internal coordinates

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

In silico simulations of STAT1 and STAT3 inhibitors predict SH2 domain cross-binding specificity.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 inhibitor.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Evaluation of anti-leukemia effect of resveratrol by modulating STAT3 signaling

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611723

Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94

23 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038/CDDIS.2014.250

Validating Stat3 in cancer therapy

21 January 2018

1 reference

12 December 2020

An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects

1 reference

12 December 2020

Discovery of a natural product inhibitor targeting protein neddylation by structure-based virtual screening

1 reference

12 December 2020

Identification of natural product fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening

1 reference

12 December 2020

Targeting STAT3 in cancer: how successful are we?

1 reference

12 December 2020

Antagonizing STAT3 dimerization with a rhodium(III) complex

1 reference

Crossref

https://api.crossref.org/works/10.1038/CDDIS.2014.250

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/CDDIS.2014.250

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24922077 AND SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24922077 AND SRC:MED&resulttype=core&format=json

8 June 2020

PubMed publication ID

24922077

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24922077 AND SRC:MED&resulttype=core&format=json