HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes. (Q36177924)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22649105 AND SRC:MED&resulttype=core&format=json

2 February 2020

title

HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22649105 AND SRC:MED&resulttype=core&format=json

2 February 2020

0 references

Juan Carlos Zuniga-Pflucker

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22649105 AND SRC:MED&resulttype=core&format=json

2 February 2020

author name string

Gladys W Wong

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22649105 AND SRC:MED&resulttype=core&format=json

2 February 2020

Gisele C Knowles

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22649105 AND SRC:MED&resulttype=core&format=json

2 February 2020

Tak W Mak

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22649105 AND SRC:MED&resulttype=core&format=json

2 February 2020

Adolfo A Ferrando

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22649105 AND SRC:MED&resulttype=core&format=json

2 February 2020

language of work or name

English

0 references

publication date

30 May 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22649105 AND SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22649105 AND SRC:MED&resulttype=core&format=json

2 February 2020

volume

120

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22649105 AND SRC:MED&resulttype=core&format=json

2 February 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22649105 AND SRC:MED&resulttype=core&format=json

2 February 2020

page(s)

1439-1448

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22649105 AND SRC:MED&resulttype=core&format=json

High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling

2 February 2020

cites work

1 reference

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The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.

1 October 2017

1 reference

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Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes.

1 October 2017

1 reference

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Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

CXCR4 acts as a costimulator during thymic beta-selection

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.

1 October 2017

1 reference

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Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

1 October 2017

1 reference

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Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum.

1 October 2017

1 reference

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The thymus as an inductive site for T lymphopoiesis

1 October 2017

1 reference

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Zoned out: functional mapping of stromal signaling microenvironments in the thymus

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Notch regulation of lymphocyte development and function.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

T-cell development made simple

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Regulation of thymocyte differentiation: pre-TCR signals and beta-selection

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Notch signaling: from the outside in

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

SDF-1 responsiveness does not correlate with CXCR4 expression levels of developing human bone marrow B cells.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Mysterious liaisons: the relationship between c-Myc and the cell cycle.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

The bHLH gene Hes1 is essential for expansion of early T cell precursors

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Delta-like 4 is indispensable in thymic environment specific for T cell development

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

The earliest thymic progenitors for T cells possess myeloid lineage potential

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Notch-induced T cell development requires phosphoinositide-dependent kinase 1.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

c-Myc mediates pre-TCR-induced proliferation but not developmental progression

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

The Ins and Outs of Notch Signaling

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Overexpression of HES-1 is not sufficient to impose T-cell differentiation on human hematopoietic stem cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Notch signaling augments T cell responsiveness by enhancing CD25 expression

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

Defining the specific physiological requirements for c-Myc in T cell development.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

A role for pref-1 and HES-1 in thymocyte development.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423782

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22649105

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

G protein-coupled chemokine receptors induce both survival and apoptotic signaling pathways

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22649105

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Adult T-cell progenitors retain myeloid potential

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22649105

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2011-12-395319

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22649105 AND SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22649105 AND SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

22649105

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22649105 AND SRC:MED&resulttype=core&format=json