Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models. (Q36177608)

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29 February 2020

title

Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models (English)

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29 February 2020

1 reference

1

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29 February 2020

Arnaud Duchon

5

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29 February 2020

Yann Hérault

6

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29 February 2020

Nathalie Janel

8

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29 February 2020

Benoît Delatour

10

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29 February 2020

author name string

Fayçal Guedj

2

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29 February 2020

Zsuza Penke-Verdier

3

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29 February 2020

Fabrice Daubigney

4

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29 February 2020

Jean-Charles Bizot

7

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29 February 2020

Nicole Créau

9

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29 February 2020

Jean M Delabar

11

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29 February 2020

publication date

20 October 2015

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Frontiers in Behavioral Neuroscience

29 February 2020

published in

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volume

9

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page(s)

267

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Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome

29 February 2020

cites work

1 reference

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Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a.

1 October 2017

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Memory coding in individuals with Down syndrome

1 October 2017

1 reference

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Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down syndrome

1 October 2017

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Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome.

1 October 2017

1 reference

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Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists.

1 October 2017

1 reference

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Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn.

1 October 2017

1 reference

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Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice

1 October 2017

1 reference

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Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer

1 October 2017

1 reference

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Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611057

The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome

1 October 2017

1 reference

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Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.

1 October 2017

1 reference

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Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome

1 October 2017

1 reference

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The specificities of protein kinase inhibitors: an update

1 October 2017

1 reference

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Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A

1 October 2017

1 reference

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Segmental trisomy as a mouse model for Down syndrome

1 October 2017

1 reference

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DYRK1A: a master regulatory protein controlling brain growth.

1 October 2017

1 reference

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Kinetic properties of a MNB/DYRK1A mutant suitable for the elucidation of biochemical pathways

2 July 2018

1 reference

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Differential regulation of GAD67, enkephalin and dynorphin mRNAs by chronic-intermittent L-dopa and A2A receptor blockade plus L-dopa in dopamine-denervated rats.

2 July 2018

1 reference

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Molecular mapping of twenty-four features of Down syndrome on chromosome 21.

2 July 2018

1 reference

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minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila

2 July 2018

1 reference

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Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4611057

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

23 September 2018

1 reference

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Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice

23 September 2018

1 reference

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Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly.

23 September 2018

1 reference

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Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.

23 September 2018

1 reference

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Working memory, response selection, and effortful processing in rats with medial prefrontal lesions.

23 September 2018

1 reference

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Familial 4.3 Mb duplication of 21q22 sheds new light on the Down syndrome critical region

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26539088

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3389/FNBEH.2015.00267

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29 February 2020

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29 February 2020

PubMed publication ID

26539088

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26539088 AND SRC:MED&resulttype=core&format=json