Life and times in biochemical toxicology (Q36176231)

12 August 2017

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title

Life and times in biochemical toxicology (English)

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12 August 2017

F Peter Guengerich

1

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12 August 2017

publication date

1 January 2005

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International Journal of Toxicology

12 August 2017

published in

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12 August 2017

volume

24

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12 August 2017

issue

1

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12 August 2017

page(s)

5-21

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Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection

12 August 2017

cites work

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https://api.crossref.org/works/10.1080/10915810590918670

STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES: INDUCTION OF TRANSFORMATION BY A DESOXYRIBONUCLEIC ACID FRACTION ISOLATED FROM PNEUMOCOCCUS TYPE III

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Paracelsus: herald of modern toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

Analysis of the effect of bulk at N2-alkylguanine DNA adducts on catalytic efficiency and fidelity of the processive DNA polymerases bacteriophage T7 exonuclease- and HIV-1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

Formation of indigo by recombinant mammalian cytochrome P450.

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Exploiting the versatility of human cytochrome P450 enzymes: the promise of blue roses from biotechnology

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Oxidation of indole by cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

The Environmental Genome Project: functional analysis of polymorphisms

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

The Vanderbilt University Center in Molecular Toxicology: the first 30 years.

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Metabolism of chemical carcinogens

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Cytochrome P450 enzymes in the generation of commercial products

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Cytochrome P450: what have we learned and what are the future issues?

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Where is toxicology headed in the future?

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Reaction of aflatoxin B(1) oxidation products with lysine

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Activation of vinyl chloride to covalently bound metabolites: roles of 2-chloroethylene oxide and 2-chloroacetaldehyde

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Kinetics of hydrolysis and reaction of aflatoxin B1 exo-8,9-epoxide and relevance to toxicity and detoxication

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Analysis of the kinetic mechanism of haloalkane conjugation by mammalian theta-class glutathione transferases

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Oxidation of methoxyphenethylamines by cytochrome P450 2D6. Analysis of rate-limiting steps.

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Formation and reactions of N(7)-aminoguanosine and derivatives.

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Structure of the aflatoxin B(1) dialdehyde adduct formed from reaction with methylamine

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Metabolism of [14C]- and [36Cl]-labeled vinyl chloride in vivo and in vitro

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Measuring gene expression by quantitative proteome analysis

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Mechanism of C8 alkylation of guanine residues by activated arylamines: evidence for initial adduct formation at the N7 position

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Reaction of aflatoxin B1 exo-8,9-epoxide with DNA: kinetic analysis of covalent binding and DNA-induced hydrolysis

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Formation and reduction of aryl and heterocyclic nitroso compounds and significance in the flux of hydroxylamines

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Olefin oxidation by cytochrome P-450: evidence for group migration in catalytic intermediates formed with vinylidene chloride and trans-1-phenyl-1-butene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

Steady-state and pre-steady-state kinetic analysis of dNTP insertion opposite 8-oxo-7,8-dihydroguanine by Escherichia coli polymerases I exo- and II exo-.

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Polymorphic hydroxylation of Debrisoquine in man.

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Brief history of chemical carcinogenesis.

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Oxidation of trichloroethylene by liver microsomal cytochrome P-450: evidence for chlorine migration in a transition state not involving trichloroethylene oxide

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Pharmacogenomics and "individualized drug therapy": high expectations and disappointing achievements

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Multifunctional nanorods for gene delivery

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA.

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Drug metabolism by Escherichia coli expressing human cytochromes P450

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

The endo-8,9-epoxide of aflatoxin B1: a new metabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

The mutagenic effect of 1,2-dichloroethane on Salmonella typhimurium I. Activation through conjugation with glutathion in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

In vitro metabolism of methylene chloride in human and animal tissues: use in physiologically based pharmacokinetic models

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Asbestos Exposure, Smoking, and Neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

Enhancement of Bacterial Mutagenicity of Bifunctional Alkylating Agents by Expression of Mammalian Glutathione S-Transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

Identification of a P-Glycoprotein-Deficient Subpopulation in the CF-1 Mouse Strain Using a Restriction Fragment Length Polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

Genetical Implications of the Structure of Deoxyribonucleic Acid

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Biosynthesis of new indigoid inhibitors of protein kinases using recombinant cytochrome P450 2A6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylainine to products genotoxic in an acetyltransferase–overexpressing Salmonella typhimurium strain (NM2009)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10915810590918670

Tetrachloroethylene oxide: hydrolytic products and reactions with phosphate and lysine

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Microsomal oxidation of tribromoethylene and reactions of tribromoethylene oxide.

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants

21 January 2018

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https://api.crossref.org/works/10.1080/10915810590918670

10.1080/10915810590918670

21 January 2018

Identifiers

DOI

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12 August 2017

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