Drugs effects on ventricular repolarization: a critical evaluation of the strengths and weaknesses of current methodologies and regulatory practices (Q36168965)

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English	Drugs effects on ventricular repolarization: a critical evaluation of the strengths and weaknesses of current methodologies and regulatory practices	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

12 August 2017

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Europe PubMed Central

Drugs effects on ventricular repolarization: a critical evaluation of the strengths and weaknesses of current methodologies and regulatory practices (English)

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Europe PubMed Central

PubMed publication ID

12 August 2017

author name string

Alan S Bass

1

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

Gordon Tomaselli

2

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Europe PubMed Central

PubMed publication ID

12 August 2017

Roy Bullingham

3

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Europe PubMed Central

PubMed publication ID

12 August 2017

Lewis B Kinter

4

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Europe PubMed Central

PubMed publication ID

12 August 2017

publication date

1 July 2005

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Europe PubMed Central

PubMed publication ID

12 August 2017

Journal of Pharmacological and Toxicological Methods

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Europe PubMed Central

PubMed publication ID

12 August 2017

52

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Europe PubMed Central

PubMed publication ID

12 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

12-21

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Europe PubMed Central

PubMed publication ID

12 August 2017

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

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Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management

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https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

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Afterpotentials and triggered activity in hypertrophied myocardium from rats with renal hypertension

1 reference

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Comparison of the cellular electrophysiological characteristics of canine left ventricular epicardium, M cells, endocardium and Purkinje fibres

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

Origins, practices and future of safety pharmacology

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

The long QT syndromes: genetic basis and clinical implications

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

Organising evidence on QT prolongation and occurrence of Torsades de Pointes with non-antiarrhythmic drugs: a call for consensus

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

The Structure of the Potassium Channel: Molecular Basis of K Conduction and Selectivity

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

Mutation of the Gene for I sK Associated With Both Jervell and Lange-Nielsen and Romano-Ward Forms of Long-QT Syndrome

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

Characteristics and distribution of M cells in arterially perfused canine left ventricular wedge preparations

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

Frequency Dependence in the Action of the Class III Antiarrhythmic Drug Dofetilide Is Modulated by Altering L-Type Calcium Current and Digitalis Glucoside

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

Sensitivity and specificity of isolated perfused guinea pig heart to test for drug-induced lengthening of QTc.

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology.

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic

1 reference

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7 January 2021

New preclinical guidelines on drug effects on ventricular repolarization: safety pharmacology comes of age.

1 reference

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7 January 2021

Safety pharmacology and risk assessment

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

The measurement of the Q-T interval of the electrocardiogram

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

Effects of benzyltetrahydropalmatine on two components of the delayed rectifier K current in Guinea pig ventricular myocytes

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

A structural basis for drug-induced long QT syndrome

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

The QT interval and torsade de pointes

1 reference

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7 January 2021

Quinidine interactions with human atrial potassium channels: developmental aspects.

1 reference

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7 January 2021

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

1 reference

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7 January 2021

Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

1 reference

https://api.crossref.org/works/10.1016/J.VASCN.2005.04.010

7 January 2021

Ionworks HT: a new high-throughput electrophysiology measurement platform

1 reference

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Cellular and ionic basis for T-wave alternans under long-QT conditions

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Cardiovascular effects of environmental chemicals

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Are surrogate markers adequate to assess cardiovascular disease drugs?

1 reference

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Sudden cardiac death in heart failure. The role of abnormal repolarization

1 reference

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Electrophysiological remodeling in hypertrophy and heart failure

1 reference

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SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

1 reference

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Drug block of I(kr): model systems and relevance to human arrhythmias

1 reference

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7 January 2021

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10.1016/J.VASCN.2005.04.010

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Europe PubMed Central

PubMed publication ID

12 August 2017

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24 November 2022

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12 August 2017

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